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Mark is joined by Sam Dotson, Dean of the George Herbert Walker School of Business and Technology at Webster University and former St. Louis Metropolitan Police Department Chief, to discuss his return to St. Louis after serving as Amtrak's chief of police. Sam shares his perspective on current policing challenges in St. Louis, including public perception of safety, law enforcement staffing shortages, and recent incidents like the Bevo Mill street takeover. Additionally, he reflects on his transition to academia and the global reach of Webster University.

Mark is joined by Cassie Smedile, Principal at Cornerstone Government Affairs and former RNC Press Secretary, to discuss the economic and political factors ahead of the upcoming midterm elections. Cassie shares her perspective on public frustration surrounding inflation and rising fuel prices, while emphasizing the long-term economic strategy behind tariffs and supply chain reshoring. The two also preview the RNC's midterm convention in Dallas, discuss key Senate races in Texas, and reflect on foreign policy developments alongside personal memories of 9/11.

In hour 1 of The Mark Reardon Show, Mark is joined by Phil Holloway, host of The Megyn Kelly True Crime Show, former Georgia assistant district attorney, and former police officer, to discuss the sudden mistrial declaration in the Lindsay Clancy murder case. Phil breaks down how a single holdout juror caused the deadlock, the legal implications of the judge's decision, and whether the prosecution will pursue a retrial or seek an out-of-court resolution. The Reardon Roundtable, made up of Tim Fitch and Ted House then joins to discuss the Clancy mistrial, Missouri Supreme Court redistricting and more. In hour 2, Ethan hosts, "Ethan's News" where he discusses the latest trending entertainment news, this day in history, the random fact of the day and more. Mark is then joined by Paul Hall, film critic at Common Guy's Film Reviews, to discuss the latest movies, streaming releases, and documentaries. The two talk about Apple TV+'s Cold War comedy-drama Mayday starring Ryan Reynolds and Kenneth Branagh, Prime Video's thriller The Runner with Gal Gadot and Damian Lewis, and Netflix's sports docuseries Untold: Raygun: Breaking Badly. They also touch on Season 2 of Chad Powers on Hulu and the widespread streaming availability of Dolly Parton's classic film 9 to 5. He is later joined by Frank Cusumano, KSDK Sports Director, to break down the latest headlines in local and national sports. Frank reacts to Mizzou football's season-opening victory over Arkansas Pine-Bluff, praising quarterback Austin Simmons' strong start while evaluating the team's areas for improvement. The two also discuss the St. Louis Cardinals' recent performance, including the promising MLB debut of catcher Leonardo Bernal and the injury setback for pitcher Hunter Dobbins. Finally, Frank weighs in on the chaotic state of college football eligibility and St. Louis City SC's roster investments. In hour 3, Mark is joined by Jonathan Dickinson, global Ibogaine expert, CEO and co-founder of Ambio Life Sciences, and author of Ibogaine and the Bicameral Mind, to discuss the therapeutic potential and clinical applications of Ibogaine. Jonathan shares insights on how Ibogaine interacts with the brain to mitigate opioid withdrawal symptoms, promote neuroplasticity, and assist in treating PTSD and traumatic brain injuries—particularly among military veterans. The two also explore ongoing clinical trials, international safety protocols, and rising legislative and federal interest in expanding research into psychedelic-assisted therapies. Mark is joined by Dan Buffa, film critic at Dose of Buffa, to review new movies, highlight streaming options, and share pop culture commentary. Dan gives his take on recent blockbusters like Spider-Man and The Odyssey, as well as Apple TV+'s Mayday starring Ryan Reynolds and Kenneth Branagh. He also reviews the Hulu series Furious starring Emmy Rossum, discusses Apple TV+'s upcoming series Brothers with Matthew McConaughey and Woody Harrelson, and reflects on the widespread cultural impact of Dolly Parton following her recent passing. He wraps up the show with the Audio Cut of the Day.

Mark is joined by Jonathan Dickinson, global Ibogaine expert, CEO and co-founder of Ambio Life Sciences, and author of Ibogaine and the Bicameral Mind, to discuss the therapeutic potential and clinical applications of Ibogaine. Jonathan shares insights on how Ibogaine interacts with the brain to mitigate opioid withdrawal symptoms, promote neuroplasticity, and assist in treating PTSD and traumatic brain injuries—particularly among military veterans. The two also explore ongoing clinical trials, international safety protocols, and rising legislative and federal interest in expanding research into psychedelic-assisted therapies.

In hour 1 of The Mark Reardon Show, Mark is joined by Phil Holloway, host of The Megyn Kelly True Crime Show, former Georgia assistant district attorney, and former police officer, to discuss the sudden mistrial declaration in the Lindsay Clancy murder case. Phil breaks down how a single holdout juror caused the deadlock, the legal implications of the judge's decision, and whether the prosecution will pursue a retrial or seek an out-of-court resolution. The Reardon Roundtable, made up of Tim Fitch and Ted House then joins to discuss the Clancy mistrial, Missouri Supreme Court redistricting and more.
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