Cases of late-onset cerebellar ataxias are a challenge for neurologists. In this episode Dr. Orlando Barsottini and Dr. José Luiz Pedroso discuss new advances on the investigation of late-onset cerebellar ataxias and identification of new genes.

Dr. Michele Matarazzo interviews Prof. Hesheng Liu about his recent Nature paper proposing a major conceptual shift: Parkinson’s disease as a somato-cognitive action network (SCAN) disorder. Together they discuss how a large multimodal dataset suggests a characteristic pattern of hyperconnectivity between SCAN cortical areas and subcortical nuclei in Parkinson’s disease, how this signature changes with effective therapies, and why personalized SCAN targeting may help refine non-invasive stimulation and circuit-guided interventions. The conversation explores implications for biomarkers, patient-specific targeting, and key unanswered questions that will shape the next generation of studies.

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In this episode, Dr. Orlando Barsottini and Dr. Bart van de Warrenburg discuss the importance of precise neurological examination and classification of ataxias. The further discuss the rational etiological investigation for cases of ataxia and how to utilize different clinical assessments.

In this episode, Dr. Kirsten Müller-Vahl explores one of the first long-term follow-up studies of mass social media–induced functional tic-like behaviors (MSMI-FTLB). She discusses what their findings mean for clinical counseling, why early diagnosis appears to improve outcomes, how factors such as psychiatric comorbidity and secondary gain influence recovery. She also examines the surprising finding that reduced screen time did not significantly affect prognosis and what this suggests about social media as a trigger versus a maintaining factor.

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Dr. Eduardo de Pablo-Fernández is joined by Dr. Susan Fox and Dr. Claudia Trenkwalder to discuss how to improve the current MDS clinical diagnostic criteria for Parkinson's disease.

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Functional dystonia can closely mimic idiopathic dystonia, and objective physiological markers to support the diagnosis are still limited. In this episode, Dr. Michele Matarazzo speaks with Prof. Roberto Eleopra about a pilot study using poly-EMG during a controlled propofol sedation protocol to help differentiate functional from idiopathic dystonia. They discuss the study’s rationale and design, the key findings, and what this approach could (and could not) add to real-world diagnostic workflows in selected complex cases.

Journal CME is available until February 19, 2027

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A young boy presents with exercise-induced episodic gait disturbance. Dr. Shekeeb Mohammad analyses the clinical phenomenology alongside laboratory and neuroimaging findings, systematically exploring the differential diagnosis before arriving at the final diagnosis.

Dr. Mena Farag joins Dr. Eduardo de Pablo-Fernández to discuss how proenkephalin and other biomarkers can help monitor the earliest stages of Huntington's disease decades before the onset of motor symptoms.

Journal CME is available until February 11, 2027

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This episode explores shame as an often-overlooked but impactful non-motor symptom of Parkinson’s disease. Drawing on her team's recent research, Dr. Vanessa Fleury discusses the psychological and clinical determinants of shame, its strong link to quality of life, and why it deserves greater attention in routine care. The conversation highlights how recognizing and addressing shame may open new avenues for more holistic, patient-centered management.

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In this episode, Dr. Alexander Lehn explores the clinical management of Parkinson’s disease across the reproductive journey; before conception, during pregnancy, and in the postpartum period. He shares the current evidence, practical challenges, medication safety considerations, and multidisciplinary decision-making. The conversation highlights gaps in data, real-world clinical strategies, and key counseling points to support optimal outcomes for both the parent and child.

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