Drs. Clayton and Payne review the burden of PPD, highlighting the importance of early and effective treatment. They explore the impact of PPD on not only postpartum patients, but also on infants, families, and society as a whole.

Drs. Clayton and Payne review strategies for the identification and diagnosis of PPD. They discuss screening, diagnostic criteria, and differential diagnosis, among other topics.

In this podcast, a study from Ontario revealed that SGLT2 inhibitors, when combined with statins, were associated with a 25% lower risk of rhabdomyolysis compared to DPP4 inhibitors. A phase I trial at Washington University demonstrated promising outcomes for a neoantigen DNA vaccine aimed at preventing recurrence in triple-negative breast cancer (TNBC). Finally, intensive systolic blood pressure control in Chinese patients with type 2 diabetes and elevated cardiovascular risk significantly reduced major cardiovascular events compared to standard care.

Drs. Payne and Clayton review in detail the management of patients with postpartum depression; discussing specific agents and classes of drugs, as well as nonpharmacological interventions and holistic and complementary approaches.

Drs. Siri and Jacobs discuss the biological treatment of patients with food allergies, reviewing currently available options, combination with immunotherapy, and other emerging therapies.

Drs. Siri and Jacobs discuss a typical case of a 4-year-old patient with peanut allergy, reviewing diagnostic and management strategies, as well as considerations such as age, IgE levels, oral food challenge, and current therapies.

Michael Putman, MD, MSci and Zachary Wallace, MD, MSc discuss a personalized approach to managing the treatment of patients with ANCA-associated vasculitis, including the role of ANCA type and titers and their impact on flare risk and treatment decisions.

NEJM reports on the safety of very early medication abortion, showing that initiating abortion medication before ultrasound confirmation is as effective and safe as the standard approach, reducing barriers in restricted settings. Another study highlighted the long-term survival impact of combining dabrafenib and trametinib for resected stage III melanoma patients with *BRAF* V600 mutations, noting a potential benefit for specific genetic profiles despite statistical limitations. Lastly, a Science study revealed that reduced sugar intake during the first thousand days of life significantly lowers the risk of diabetes and hypertension, emphasizing early intervention as a lifelong health measure.

Drs. Zachary Wallace and Michael Putman continue their induction therapy discussion in patients with ANCA-associated vasculitis, reviewing the use of glucocorticoids, avacopan, and plasma exchange.

Sami Diab, MD and Tejas Patil, MD continue their discussion about emerging treatments for HER2+ lung cancer, including data presented from DESTINY-Lung03, liquid biopsies, emerging resistance, and treatment sequencing..