"Current treatments for osteoarthritis mostly provide symptomatic relief, and so disease-modifying drugs that target the underlying structural damage would be a game changer. But despite multiple attempts, no DMOAD is yet approved for clinical use.

Prof. Ali Mobasheri takes us through the main challenges, the work being done to address them to make these so-called utopia drugs a reality, and other advances that can offer some hope in the meantime."

Roughly 50% of women over 50 experience sexual dysfunction, yet fewer than 20% report it to their doctor, thinking these changes are 'just part of aging'.

As doctors, we should be helping women lead sexually healthy and fulfilling lives as they age. Prof Holly Thomas tells us how.

The POSITIVE trial previously showed that women with breast cancer can safely interrupt endocrine therapy in order to become pregnant. But what about breastfeeding - is that possible and safe for the mother and baby?

Women can take heart from the latest findings, says Dr. Cristina Saura, as she takes us through these important clinical updates.

Blood-based biomarkers are set to make biological assessment of Alzheimer's disease much quicker and more accessible than has been possible with imaging and CSF biomarkers. Does this mean the disease now be defined as a purely biological entity?

Dr. Nicolas Villain outlines why it is still so important to consider both clinical symptoms and biological findings when making a diagnosis.

Metabolic dysfunction-associated liver disease is a significant healthcare concern and burden. Until recently there was no approved pharmacologic treatment for the more serious form of the disease, metabolic dysfunction-associated steatohepatitis.

In this wide-ranging conversation, Prof. Vlad Ratziu explains the rationale behind the recently updated subclassification and nomenclature for steatotic liver disease, puts the therapeutic advance of resmetirom into context, and looks to the future for MASLD and MASH.

Since publication of the Berlin criteria for ARDS in 2012, several developments have prompted the need for an update. Last year, an international group of experts rose to the challenge.

But is the new definition necessary and will it have an impact on clinical practice? Prof. Giacomo Grasselli shares his thoughts.

Nearly half of adults over the age of 65 have some degree of frailty, and over two-thirds have cardiac disease.

Dr Eduard Shantsila discusses the importance of individualised rehabilitation programmes in these patients, to reduce morbidity and mortality, and improve quality of life.

For more on how Springer Medicine can tailor medical education to meet your needs, head to SpringerMedicine.com and register for updates.

Despite many recent advances in its management, type 1 diabetes remains a burden for those living with the condition.

Prof Chantal Mathieu explains the progress being made with disease-modifying therapy for type 1 diabetes and how it has the potential to transform the current treatment landscape.

For more on how Springer Medicine can tailor medical education to meet your needs, head to SpringerMedicine.com and register for updates.

Recent research suggests that the gut microbiome could be an important modulator of response to CAR T-cell therapy in patients with hematologic cancers.

Prof. Marion Subklewe takes us through the latest evidence, highlighting the impact of antibiotics, nutrition, and dietary supplements, and discusses how to devise interventions to improve patient outcomes.

For more on how Springer Medicine can tailor medical education to meet your needs, head to SpringerMedicine.com and register for updates.

About 50% of stroke patients have an unfavorable outcome. Predicting outcome is challenging but is key to understanding how best to treat patients.

Prof. Susanne Wegener discusses her team’s work to develop deep learning models that outperform neurologists when predicting outcome based on imaging data alone or in combination with clinical data.

For more on how Springer Medicine can tailor medical education to meet your needs, head to SpringerMedicine.com and register for updates.