Medscape InDiscussion: Ulcerative Colitis

Pouch expert Dr Laura Raffals joins Dr Sunanda Kane to deep-dive into patient care after J-pouch surgery. Topics include pouchitis, Crohn's of the pouch, pelvic floor dysfunction, and pregnancy.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984009). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Ulcerative Colitis https://emedicine.medscape.com/article/183084-overview

Ileal Pouch-anal Anastomosis https://emedicine.medscape.com/article/1892231-overview

Northwestern Medicine Feinberg School of Medicine Faculty Profiles https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=29442

Microbiome Analysis of Mucosal Ileoanal Pouch in Ulcerative Colitis Patients Revealed Impairment of the Pouches Immunometabolites https://pubmed.ncbi.nlm.nih.gov/34831464/

University of Chicago, Biological Sciences Division Faculty https://biologicalsciences.uchicago.edu/faculty/eugene-b-chang-md

Mayo Clinic Department of Gastroenterology and Hepatology Biographies https://www.mayoclinic.org/biographies/camilleri-michael-m-d/bio-20054405

Crohn Disease https://emedicine.medscape.com/article/172940-overview

Complications Related to J-pouch Surgery https://pubmed.ncbi.nlm.nih.gov/30846911/

A Systematic Review: The Management and Outcomes of Ileal Pouch Strictures https://pubmed.ncbi.nlm.nih.gov/29155985/

Pre-pouch Ileitis Is Associated With Development of Crohn's Disease-like Complications and Pouch Failure https://pubmed.ncbi.nlm.nih.gov/33300546/

Primary Sclerosing Cholangitis https://emedicine.medscape.com/article/187724-overview

Pathologic Features and Clinical Significance of "Backwash" Ileitis in Ulcerative Colitis https://pubmed.ncbi.nlm.nih.gov/16224214/

Efficacy and Safety of Biologics and Small Molecule Drugs for Patients With Moderate-to-severe Ulcerative Colitis: A Systematic Review and Network Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/34856198/

Anastomotic Leak After Ileal Pouch-Anal Anastomosis https://pubmed.ncbi.nlm.nih.gov/34853564/

Inflammatory Bowel Disease https://emedicine.medscape.com/article/179037-overview

Ileostomy https://pubmed.ncbi.nlm.nih.gov/30085545/

Pelvic Floor Dysfunction https://pubmed.ncbi.nlm.nih.gov/32644672/

The London Classification: Improving Characterization and Classification of Anorectal Function With Anorectal Manometry https://pubmed.ncbi.nlm.nih.gov/32935278/

Defining Normal Pouch Function in Patients With Ileal Pouch-Anal Anastomosis: A Pilot Study https://pubmed.ncbi.nlm.nih.gov/35274320/

MR Defecography Review https://pubmed.ncbi.nlm.nih.gov/31544226/

Pouch Function and Gastrointestinal Complications During Pregnancy After Ileal Pouch-anal Anastomosis https://pubmed.ncbi.nlm.nih.gov/20608799/

Drs Sunanda Kane and Peter D. Higgins discuss the first 72 hours of inpatient UC care. What are best practices for diet and painkillers? When should your patient see a surgeon? Tune in to find out.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984006). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Ulcerative Colitis https://emedicine.medscape.com/article/183084-overview

Efficacy and Safety of Biologics and Small Molecule Drugs for Patients With Moderate-to-Severe Ulcerative Colitis: A Systematic Review and Network Meta-analysis https://pubmed.ncbi.nlm.nih.gov/34856198/

Anti-TNF Therapy https://pubmed.ncbi.nlm.nih.gov/27726761/

Cyclosporine in Severe Ulcerative Colitis Refractory to Steroid Therapy https://pubmed.ncbi.nlm.nih.gov/8196726/

Developing an Instrument to Assess the Endoscopic Severity of Ulcerative Colitis: The Ulcerative Colitis Endoscopic Index of Severity (UCEIS) https://pubmed.ncbi.nlm.nih.gov/21997563/

Fecal Calprotectin https://pubmed.ncbi.nlm.nih.gov/30342711/

Tofacitinib Induction Therapy Reduces Symptoms Within 3 Days for Patients With Ulcerative Colitis https://pubmed.ncbi.nlm.nih.gov/30012431/

The Janus Kinases (Jaks) https://pubmed.ncbi.nlm.nih.gov/15575979/

Inpatient Therapy With Calcineurin Inhibitors in Severe Ulcerative Colitis https://pubmed.ncbi.nlm.nih.gov/33319248/

Join Drs Sunanda Kane and Linda (Annie) Feagins as they discuss dietary issues such as malnutrition; fiber, dairy, gluten, and red meat intake; and hospital meal plans when treating patients with UC.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984005). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Inflammatory Bowel Disease https://emedicine.medscape.com/article/179037-overview

Malnutrition and Quality of Life Among Adult Inflammatory Bowel Disease Patients https://onlinelibrary.wiley.com/doi/full/10.1002/jgh3.12278

Role of Diet in the Development and Management of Crohn's Disease https://pubmed.ncbi.nlm.nih.gov/32185530/

Gluten-Free Diet in IBD: Time for a Recommendation? https://pubmed.ncbi.nlm.nih.gov/32558265/

Use of the Low-FODMAP Diet in Inflammatory Bowel Disease https://onlinelibrary.wiley.com/doi/10.1111/jgh.13695

Inulin and Oligofructose in Chronic Inflammatory Bowel Disease https://academic.oup.com/jn/article/137/11/2572S/4664508?login=false

A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults With Crohn's Disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396394/

Breaking the Vicious Cycle: Intestinal Health Through Diet (by Elaine Gottschall) https://breakingtheviciouscycle.info/

A Diet Low in Red and Processed Meat Does Not Reduce Rate of Crohn's Disease Flares https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726378/

The Role of Carrageenan in Inflammatory Bowel Diseases and Allergic Reactions: Where Do We Stand? https://pubmed.ncbi.nlm.nih.gov/34684400/

Join Drs Sunanda Kane and Uma Mahadevan as they set out to separate fact from fiction when treating patients with ulcerative colitis before, during, and after pregnancy.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984004). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

PIANO (Pregnancy Inflammatory bowel disease And Neonatal Outcomes) https://gastroenterology.ucsf.edu/research/piano

Ileal Pouch–Anal Anastomosis https://emedicine.medscape.com/article/1892231-overview

Does Laparoscopic IIeal Pouch–Anal Anastomosis Reduce Infertility Compared With Open Approach? https://pubmed.ncbi.nlm.nih.gov/31420214/

The Impact of Medical Therapies and Factors Related to Treatment Procedures in Women With Rheumatoid Arthritis and Inflammatory Bowel Disease Receiving Assisted Reproduction: A Nationwide Cohort Study https://www.fertstert.org/article/S0015-0282(21)01797-0/fulltext

Effects of 6-Mercaptopurine Treatment on Sperm Production and Reproductive Performance: A Study in Male Mice https://pubmed.ncbi.nlm.nih.gov/16028439/

Paternal Exposure to Immunosuppressive and/or Biologic Agents and Birth Outcomes in Patients With Immune-Mediated Inflammatory Diseases https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238837/

Child-Mother Index: A New Risk Factor for Selected Adverse Maternal Birth Outcomes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758341/

Association of a Mediterranean Diet Pattern With Adverse Pregnancy Outcomes Among US Women https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2799855

Fecal Calprotectin During Pregnancy in Women With Moderate-Severe Inflammatory Bowel Disease https://academic.oup.com/ibdjournal/article/24/4/839/4913664

Fecal Calprotectin as a Predictor of Abnormal Colonic Histology https://pubmed.ncbi.nlm.nih.gov/17963005/

Safety of Flexible Sigmoidoscopy in Pregnant Patients With Known or Suspected Inflammatory Bowel Disease https://link.springer.com/article/10.1007/s10620-020-06122-8

Dr Sunanda Kane explores the evidence and effectiveness of alternative therapies with guest Dr David Hass. From probiotics to CBD to FMT, dive into the various approaches to managing UC.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984003). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

VSL#3 https://vsl3.com/

Curcumin in Combination With Mesalamine Induces Remission in Patients With Mild-to-Moderate Ulcerative Colitis in a Randomized Controlled Trial https://www.cghjournal.org/article/S1542-3565(15)00158-5/fulltext

Theracurmin® HP https://www.integrativepro.com/products/theracurmin-hp

A Systematic Review and Meta-analysis of Randomized Controlled Trials of Fecal Microbiota Transplantation for the Treatment of Inflammatory Bowel Disease https://www.hindawi.com/journals/ecam/2022/8266793/

Gut Microbiota and Autoimmune Diseases: A Charming Real World Together With Probiotics https://www.eurekaselect.com/article/118132

Results of the First Pilot Randomized Controlled Trial of Fecal Microbiota Transplant in Pediatric Ulcerative Colitis: Lessons, Limitations, and Future Prospects https://www.gastrojournal.org/article/S0016-5085(21)00739-3/fulltext

Fecal Microbiota Transplantation in Inflammatory Bowel Disease Patients: A Systematic Review and Meta-analysis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500646/

Cannabis Induces a Clinical Response in Patients With Crohn's Disease: A Prospective Placebo-Controlled Study https://www.cghjournal.org/article/S1542-3565(13)00604-6/fulltext

Marijuana Use Patterns Among Patients With Inflammatory Bowel Disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126607/

Drs Kane and Chedid discuss inclusive care for LGBTQIA+ patients including sexual and gender minority terminology, asking about patient's sexual preferences in clinic, and the health disparities faced by the LGBTQIA+ population with IBD.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/984000). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Gender Bear https://www.queerlapis.com/gender-bear/

Providing Trans-Affirming Care for Sexual Assault Survivors: An Evaluation of a Novel Curriculum for Forensic Nurses https://www.sciencedirect.com/science/article/pii/S0260691720302252?via%3Dihub

What Is a Top Surgery for Transgender People? https://www.webmd.com/a-to-z-guides/what-is-top-surgery-transgender-people

What Is Chest Binding? https://www.webmd.com/a-to-z-guides/what-is-chest-binding

Surgical Treatment of Ulcerative Colitis https://emedicine.medscape.com/article/937427-overview

Assessment of Health Conditions and Health Service Use Among Transgender Patients in Canada https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2769915

Netnography https://www.researchgate.net/publication/319613944_Netnography

Receptive Anal Intercourse in Patients With Inflammatory Bowel Disease: A Clinical Review https://academic.oup.com/ibdjournal/article/23/8/1285/4560709