Ch. 46 offers a comprehensive overview of various upper gastrointestinal (GI) disorders, focusing on their etiology, pathophysiology, clinical manifestations, and management. Key topics include the common issues of nausea and vomiting, as well as more specific conditions such as oral cancer, gastroesophageal reflux disease (GERD), hiatal hernia, esophageal cancer, and peptic ulcer disease (PUD). The material also addresses complications associated with these disorders, including GI bleeding, perforation, and gastric outlet obstruction, along with the nursing and interprofessional care required for patients experiencing these issues. Finally, the text briefly touches upon gastritis, foodborne illnesses, and the implications of gastric surgery.