Today we feature Quantum-SI, one of the new wave of proteomics tools companies.  The company was founded by serial life science entrepreneur, Jonathan Rothberg, originally as a long read sequencing company.    Though the company pivoted to proteomics, they kept the sequencing part.

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SynBioBeta is the largest gathering of the synthetic biology community worldwide.  It’s taking place May 23-25 in Oakland, California.  John Cumbers is the founder and CEO of the conference, and he joins us to talk about trends in the space and preview this year’s confab.
First, we discuss the impact Washington D.C. is having on the field.  What doe’s Biden’s love for bio mean for synbio?

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It’s a thrilling time to be in proteomics.  Today we discuss a recent paper in PLOS One demonstrating how new technology has revealed a novel biomarker for non-small cell lung cancer previously undetected by other methods.  The paper could be a model for new proteomics research going forward.  Our guests are Margaret Donovan, Product Marketing Manager, and Asim Siddiqui, Senior VP of Research, both at proteomics company, Seer.

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Philosophers talk about various kinds of knowledge.  There is knowing that something is.  We learn that the sun is 90 million miles from the Earth.  There is also knowing how to do something.  This includes skills we learn like riding a bike or cooking spaghetti.  Knowing how is different from knowing that.

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Long DNA has arrived.   Elegen, a new company based in San Carlos, California,  is out this year offering just long DNA.  According to their founder and CEO, Matt Hill and today's guest, the company’s product is twenty times more accurate than anything else presently available.
What does this mean for the world of biology and the world in general that we're seeing the emergence of a new subindustry devoted specifically to long DNA?

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"We’re not a sequencing company," says Molly He, CEO and co-founder of Element Biosciences in our first interview with the leader of the hot new sequencing company which seemed to come out of nowhere this past year. “We’re a biology company.”
Not a sequencing company? Element has just taken the lead in the race toward cheap clinical genomes, and their CEO is putting that news aside in today’s interview. Instead, she’s much more interested in touting the company’s core technology “avidity.” The term comes from a core reagent the company has labeled an “avidite.”

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Biology is complex, and the life science tool kit continues to expand to meet the challenge of that complexity taking us into the world of multi omics and beyond. Today we talk about 3D genomics and what this additional three-dimensional structural information is telling not just researchers, but clinicians, particularly in oncology.

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Today we talk with Simon Fredriksson, CEO and co-founder of Pixelgen Technologies, a company just out of stealth offering spatial technology that maps cellular surface proteins at the single cell level. Called molecular pixelation, the breakthrough technology is designed to first target immune cells.

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Editor's Note: Theral's mic malfunctioned in this interview. Fortunately the not as good backup mic did work and John has a good mic.  Our apologies.
John Greally joins us today. He is the founding Director of the Albert Einstein College of Medicine’s Center for Epigenomics. He’s a pediatrician and a clinical geneticist with appointments in both at Einstein.

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Last month the American Society of Human Genetics (ASHG) took a quite remarkable step, putting out a formal statement of apology for its past history of involvement with eugenics. Some say it’s long overdue while some of us didn’t know about this history.

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