"Hi, listeners! Did you know that our bodies have a bunch of tiny 'mystery molecules' that control everything from how our genes work to how our brain sends messages? Well, scientists are getting closer to understanding them through a family of enzymes called METTLs. These little guys are like the body's secret chefs, adding a special ingredient, called methylation, to different molecules. A new study shows they're involved in everything from turning genes on and off to making sure our brain chemicals are just right. With over 80% of these enzymes now identified, we're one step closer to understanding the body's inner workings. Tune in to learn more about these fascinating molecules and how they might help us stay healthy!"

欢迎收听今日医学前沿，今天我们要探讨的是《糖尿病学》杂志上的一项突破性研究。这项研究由IMI-DIRECT联盟进行，他们分析了3000份血浆样本，发现了与2型糖尿病和前驱糖尿病相关的特定代谢物。研究发现，特定的支链氨基酸、脂质和新的N-乙酰氨基酸代谢物与糖尿病的进展密切相关。更重要的是，他们还发现了一些代谢物和2型糖尿病之间的因果关系，这对于糖尿病的预防和治疗具有重要意义。这项研究不仅为我们提供了新的生物标志物，还可能引领针对这些标志物的个性化干预措施。不要错过这场医学盛宴，让我们深入了解这些发现如何改变我们对2型糖尿病的理解。