Minding Memory

The population of older adults living with dementia is expected to swell to nearly 14 million by 2050 and is estimated to cost the US economy more than 500 billion each year. In the absence of a cure for Alzheimer's disease, the primary cause of dementia, there's interest in understanding modifiable risk factors. In theory, getting a handle on the modifiable risk factors for dementia, would enable public health efforts to reduce cognitive decline in dementia at the population level. We've come a long way in understanding the risk factors for Alzheimer's disease and other related dementias. However, there's still work to be done. In this episode, we'll speak with Dr. Josh Ehrlich, a researcher at the University of Michigan, who has examined vision impairment as a risk factor for dementia. 

Joshua Ehrlich Faculty Profile: https://medicine.umich.edu/dept/ophthalmology/joshua-r-ehrlich-md-mph

Articles Referenced in the Podcast:  

Ehrlich JR, Goldstein J, Swenor BK, Whitson H, Langa KM, Veliz P. Addition of Vision Impairment to a Life-Course Model of Potentially Modifiable Dementia Risk Factors in the US. JAMA Neurol. 2022 Jun 1;79(6):623-626. doi: 10.1001/jamaneurol.2022.0723. Erratum in: JAMA Neurol. 2022 Jun 1;79(6):634. PMID: 35467745; PMCID: PMC9039828. 

New York Times Article, July 2022: New Dementia Prevention Method May Be Behavioral, Not Prescribed 

Lancet Commission on Dementia Prevention, Intervention, and Care (2020)  

Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, Brayne C, Burns A, Cohen-Mansfield J, Cooper C, Costafreda SG, Dias A, Fox N, Gitlin LN, Howard R, Kales HC, Kivimäki M, Larson EB, Ogunniyi A, Orgeta V, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbæk G, Teri L, Mukadam N. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020 Aug 8;396(10248):413-446. doi: 10.1016/S0140-6736(20)30367-6. Epub 2020 Jul 30. Erratum in: Lancet. 2023 Sep 30;402(10408):1132. PMID: 32738937; PMCID: PMC7392084. 

The transcript for this episode can be found here.

CAPRA Website: http://capra.med.umich.edu/ 

You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.

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According to an estimate published in 2015, the global prevalence of dementia was projected to nearly triple between 2015 and 2050, growing from 46 million to over 130 million people globally. And of that worldwide share, 70% of those with dementia will be in low- and middle-income countries. Tackling and ideally preventing dementia requires a global perspective. In this episode, Matt & Donovan speak with Dr. Lindsay Kobayashi, a faculty member in the Department of Epidemiology at the University of Michigan School of Public Health whose research focuses on the social epidemiology of aging from a global perspective. Dr. Kobayashi introduces us to a whole new world of data available to help researchers tackle dementia as a global challenge.  

Lindsay Kobayashi Faculty Profile: https://sph.umich.edu/faculty-profiles/kobayashi-lindsay.html   

Article referenced in this episode: 

Kobayashi LC, Gross AL, Gibbons LE, Tommet D, Sanders RE, Choi SE, Mukherjee S, Glymour M, Manly JJ, Berkman LF, Crane PK, Mungas DM, Jones RN. You Say Tomato, I Say Radish: Can Brief Cognitive Assessments in the U.S. Health Retirement Study Be Harmonized With Its International Partner Studies? J Gerontol B Psychol Sci Soc Sci. 2021 Oct 30;76(9):1767-1776. doi: 10.1093/geronb/gbaa205. PMID: 33249448; PMCID: PMC8557836. 

The transcript for this episode can be found here.

CAPRA Website: http://capra.med.umich.edu/ 

You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.

Hosted on Acast. See acast.com/privacy for more information.

Over thirty percent of individuals living with dementia living in the US each year die either of or with dementia – and almost half of those enrolled in hospice have dementia. As with so many other types of healthcare, there are disparities in both who enrolls in hospice as well as the type of care these individuals receive after enrollment. In this episode, Matt & Donovan talk with Dr. Lauren Hunt from UCSF, an expert in hospice care for persons living with dementia, about dementia at the end of life.   

Lauren Hunt Faculty Profile: https://profiles.ucsf.edu/lauren.hunt  

Article referenced in this episode: 

Hunt LJ, Gan S, Smith AK, Aldridge MD, Boscardin WJ, Harrison KL, James JE, Lee AK, Yaffe K. Hospice Quality, Race, and Disenrollment in Hospice Enrollees With Dementia. J Palliat Med. 2023 Aug;26(8):1100-1108. doi: 10.1089/jpm.2023.0011. Epub 2023 Apr 3. PMID: 37010377; PMCID: PMC10440673. 

Article on identifying disenrollment in claims data:  

Hunt LJ, Gan S, Boscardin WJ, Yaffe K, Ritchie CS, Aldridge MD, Smith AK. A national study of disenrollment from hospice among people with dementia. J Am Geriatr Soc. 2022 Oct;70(10):2858-2870. doi: 10.1111/jgs.17912. Epub 2022 Jun 7. PMID: 35670444; PMCID: PMC9588572. 

The transcript for this episode can be found here.

CAPRA Website: http://capra.med.umich.edu/ 

You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.

Hosted on Acast. See acast.com/privacy for more information.

Extreme weather and weather-related disasters are becoming more and more common. Unfortunately, disaster related disruptions in healthcare tend to affect the most vulnerable of populations – including older adults living with cognitive impairment. In this episode, Matt & Donovan speak with University of Michigan faculty member, Sue Anne Bell, about how healthcare disruption due to a disaster can affect the population of older adults living with dementia. 

Sue Anne Bell Faculty Link: https://nursing.umich.edu/faculty-staff/faculty/sue-anne-bell  

Article referenced in podcast:  

Bell SA, Miranda ML, Bynum JPW, Davis MA. Mortality After Exposure to a Hurricane Among Older Adults Living With Dementia. JAMA Network Open. 2023 Mar 1;6(3):e232043. doi: 10.1001/jamanetworkopen.2023.2043. PMID: 36881412; PMCID: PMC9993175. 

The transcript for this episode can be found here.

CAPRA Website: http://capra.med.umich.edu/ 

You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.

Hosted on Acast. See acast.com/privacy for more information.

In this episode of Minding Memory, we dive into the newest FDA-approved drug to treat Alzheimer’s – Lecanemab – with Ohio State University stroke neurologist Jim Burke. Dr. Burke discusses the benefits and drawbacks of the new Alzheimer’s drug and also the paradigm shift of how people (clinicians, patients, and the general population) are thinking about these news Alzheimer’s medications.  

Jim Burke Faculty Profile: https://wexnermedical.osu.edu/find-a-doctor/james-burke-md-128794  

Article referenced in podcast: Burke JF, Richard S, Langa KM, Albin RL, Kotagal V. Lecanemab: Looking Before We Leap. Neurology. 2023 Jul 21: doi: 10.1212/WNL.0000000000207505. Epub ahead of print. PMID: 37479527. 

The transcript for this episode can be found here.

CAPRA Website: http://capra.med.umich.edu/ 

You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.

Hosted on Acast. See acast.com/privacy for more information.

In this episode, Donovan & Matt talk with health services researcher Betsy White from Brown University about a unique new resource for researchers called the Long-Term Data Cooperative, a provider-led data sharing collaboratory that puts together nursing home EHR data from EHR vendors that can be linked to Medicare claims. This powerful tool is made available to researchers through an online application process. 

This episode references the RFA for the Real-World Data Scholars Program, which is now expired. However, Minding Memory listeners can find out about upcoming opportunities or future RFAs by emailing [email protected]. 

Betsy White Faculty Profile: https://vivo.brown.edu/display/ewhite14  

Long Term Care Data Cooperative: https://www.ltcdatacooperative.org/Pages/default.aspx  

The transcript for this episode can be found here.

CAPRA Website: http://capra.med.umich.edu/ 

You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.

Hosted on Acast. See acast.com/privacy for more information.

In this episode, Matt & Donovan speak with University of Michigan School of Public Health Professor, Dr. J. Scott Roberts, who investigates the psychological and behavioral impact of genetic risk disclosure for Alzheimer's disease.  

In addition to being a professor in the Health Behavior & Health Education department at the School of Public Health, Dr. Roberts is also a core lead of the Michigan Alzheimer’s Disease Center. Dr. Roberts’s research interests focus on the process and impact of risk assessment and disclosure for adult-onset disorders, as well as the ethical, legal, and social implications of advances in genomic science & technology. 

Faculty Profile: https://sph.umich.edu/faculty-profiles/roberts-j.html 

Michigan Alzheimer’s Disease Center (MDAC): https://alzheimers.med.umich.edu/

The transcript for this episode can be found here.

CAPRA Website: http://capra.med.umich.edu/ 

You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.

Hosted on Acast. See acast.com/privacy for more information.

In this episode, Matt & Donovan speak with a health economist, Dr. Lauren Nicholas, whose research investigates how missing a single credit card payment may be a very early indicator of a cognitive issue. Dr. Nicholas is an associate professor in the department of Health Systems Management & Policy at the University of Colorado School of Public Health and has published several studies that examined on how a financial issue might be among the first signs of cognitive decline. 

Lauren Nicholas Faculty Profile: https://coloradosph.cuanschutz.edu/resources/directory/directory-profile/Nicholas-Lauren-UCD6003780837  

Article referenced in this episode:  

Nicholas LH, Langa KM, Bynum JPW, Hsu JW. Financial Presentation of Alzheimer Disease and Related Dementias [published correction appears in JAMA Intern Med. 2021 Feb 1;181(2):296]. JAMA Intern Med. 2021;181(2):220-227. doi:10.1001/jamainternmed.2020.6432 

The transcript for this episode can be found here.

CAPRA Website: http://capra.med.umich.edu/ 

You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.

Hosted on Acast. See acast.com/privacy for more information.

In this episode, Donovan & Matt speak with Geoffrey Hoffman, a faculty member and researcher at the University of Michigan School of Nursing. Dr. Hoffman discusses the transition to the role of caregiver for partners of persons diagnosed with dementia – and the unique emotional burden and stress that they undertake. Dr. Hoffman also discusses using the Health & Retirement Study (HRS) to better explore the emotional stress and onset of depression in caregivers.   

Geoff Hoffman Faculty Profile: https://nursing.umich.edu/faculty-staff/faculty/geoffrey-j-hoffman 

Article Referenced in this Episode 

Harris ML, Errickson J, Ha J, Hoffman GJ. Depressive Symptoms and Caregiving Intensity Before and After Onset of Dementia in Partners: A Retrospective, Observational Study. Med Care. 2022;60(11):844-851. doi:10.1097/MLR.0000000000001771 [PMID: 36038513] 

The transcript for this episode can be found here.

CAPRA Website: http://capra.med.umich.edu/ 

You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.

Hosted on Acast. See acast.com/privacy for more information.

In this episode we’ll speak with Dr. Julie Bynum who was the senior author on a recent study that examined how the likelihood of receiving a diagnosis of dementia has changed over the last decade or so. We’ll discuss what this might mean clinically and what researchers that rely on Medicare data should take-away from this finding. We also will talk in general about the various approaches that exist for identification of dementia in Medicare billing data. 

Julie Bynum Faculty Profile: https://medicine.umich.edu/dept/dgpm/julie-bynum-md-mph  

Article Referenced in this Episode 

Davis MA, Chang CH, Simonton S, Bynum JPW. Trends in US Medicare Decedents' Diagnosis of Dementia From 2004 to 2017. JAMA Health Forum. 2022 Apr 1;3(4):e220346. doi: 10.1001/jamahealthforum.2022.0346. PMID: 35977316 

Resources:  

The Bynum-Standard 1-Year Algorithm for identifying Alzheimer’s Disease and Related Dementias (ADRD) in Medicare Claims data.  

The transcript for this episode can be found here.

CAPRA Website: http://capra.med.umich.edu/ 

You can subscribe to Minding Memory on Apple Podcasts, Spotify, Google Podcasts or wherever you listen to podcasts.

Hosted on Acast. See acast.com/privacy for more information.