This podcast covers some misconceptions about glucose and its perceived bad effects on health. Glucose is an essential energy source for many tissues that almost exclusively depend on it availability in the bloodstream. In fact, through coordinated release of hormones and their various tissue effects, glucose is maintained between 80-100 mg/ dl during fasting and sleep with the purpose of supplying glucose to tissues that depend on it. Restoring blood glucose under fasting conditions is primarily accomplished by the liver. Although elevated plasma glucose can cause some health risks, the tissue requirement for glucose as an energy source can not be overlooked.