ModPath Chat

ModPath Chat

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ModPath Chat episodes

  • Artificial intelligence for advance requesting of IHC in diagnostically uncertain prostate biopsies
    Dr. Clare Verrill and Andrea Chatrian of Oxford University in England discuss their team’s study on AI for advance ordering of IHC in difficult prostate biopsy. Their elegant work shows that an AI tool making automated IHC request prior to the pathologist read of H&E could create leaner workflow and result in pathologist time savings and shorten overall Turnaround time from accession to final diagnosis. Study by Chatrian et al, Artificial intelligence for advance requesting of immunohistochemistry in diagnostically uncertain prostate biopsies. https://www.nature.com/articles/s41379-021-00826-6
    20 min
  • Synchronous Endometrial and Ovarian Carcinomas: Clonal relationship and directionality of progression.

    Dr. Britta Weigelt of MSKCC discusses her team’s study on synchronous endometrial (EC) and ovarian carcinomas (OC) in Lynch syndrome and constitutional Mismatch Repair Deficiency Syndrome (CMMRD). Contrary to sporadic synchronous ECs/OCs, which are almost invariably clonally related, ECs/OCs simultaneously involving the uterus and ovary in LS patients may represent two independent primary tumors. Like their sporadic counterparts, a subset of MMR deficiency syndrome-related synchronous ECs/OCs may also originate from a single with the endometrium being the likeliest site of origin.

    Study by Weigelt et al, Clonal relationship and directionality of progression of synchronous endometrial and ovarian carcinomas in patients with DNA mismatch repair-deficiency associated syndromes. Modern Pathology, 34, 994-1007, 2021. https://www.nature.com/articles/s41379-020-00721-6.

    21 min
  • Deciphering the Molecular Underpinning of Ulcerative Colitis Associated Colorectal Cancer
    Dr. Daniela Hirsch, from the Institute of Pathology at the University of Heidelberg in Germany, discusses her findings on the molecular alterations associated with colorectal cancer in the setting of Ulcerative Colitis. Using aCGH, a 48 gene panel and MSI analysis and IHC for TP53, the author and her team revealed high rate of TP53 mutations and gains in chromosome 5p in these predominantly Microsatellite stable tumors. Phylogenic clues about ontogenesis and field effect are discerned from synchronous tumors.
    15 min
  • Post Neo-adjuvant Chemotherapy Patterns of Residual Breast Cancer

    Dr. Stuart Schnitt from Brigham and Women Hospital in Boston discusses his team'srecent findings of variable architectural and cytological patterns of residual disease in breast cancer patients with incomplete pathologic response. The relationship of pattern of residual disease to pre-treatment clinicopathologic parameters and the potential impact on management are discussed.

    Study by Pastorello et al, Clinico-pathologic predictors of patterns of residual disease following neoadjuvant chemotherapy for breast cancer. Modern Pathology, 34, 875-882, 2021. https://www.nature.com/articles/s41379-020-00714-5.

    21 min
  • "Rebranding" Hematopathology Using Twitter: The MD Anderson Experience
    In this episode, our guests, Dr. Siba El Hussein and Dr. Sanam Loghavi from the department of hematopathology at MD Anderson Cancer Ctr, discuss their experience on the role of social media in the dissemination of knowledge in hematopathology and establishing networks of collaborators and followers. Editorial by El Hussein et al, Next-Generation Scholarship: Rebranding Hematopathology Using Twitter: The MD Anderson Experience. Modern Pathology, 34, 854-861, 2021. https://www.nature.com/articles/s41379-020-00715-4
    20 min
  • “Rebranding” Hematopathology Using Twitter: The MD Anderson Experience
    In this episode, our guests, Dr. Siba El Hussein and Dr. Sanam Loghavi from the department of hematopathology at MD Anderson Cancer Ctr, discuss their experience on the role of social media in the dissemination of knowledge in hematopathology and establishing networks of collaborators and followers. Editorial by El Hussein et al, Next-Generation Scholarship: Rebranding Hematopathology Using Twitter: The MD Anderson Experience. Modern Pathology, 34, 854-861, 2021. https://www.nature.com/articles/s41379-020-00715-4

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    20 min
  • USCAP 2021 Long Course: Biomarkers of Response to Check Point Inhibitors - beyond PD-L1
    In this fourth and final episode of our special series covering this year’s USCAP Long Course on lung disease, our guest, Dr. Lynette Sholl, chief of pulmonary pathology at the Brigham and Women Hospital discusses her presentation on "Biomarkers of Response to Checkpoint Inhibitors". Dr. Sholl touches upon the potential role of CD8+ T cell count, Multiplex IF based spatial profiling and novel genomic determinants as markers beyond PD-L1.
    18 min
  • USCAP 2021 Long Course: Neuroendocrine Tumors of Lung, a Decade of Change!
    In this third of four special episodes highlighting the USCAP 2021 Long Course on Pulmonary Pathology, our host discusses with Dr. Natasha Rekhtman of Memorial Sloan Kettering Cancer Center (MSKCC) her presentation on Neuroendocrine tumors. Dr. Rekhtman offers her perspective on the current status of the classification of pulmonary NE tumors and the "grey zones" that remain to be tackled.  
    23 min
  • USCAP 2021 Long Course: "Pulmonary Pathology: Practical Problems and Solutions". HP, FHP, CTILD, UIP/IFP and more!
    In this second of four special episodes highlighting the USCAP 2021 Long Course on Pulmonary Pathology, our host is joined by two distinguished faculty: Dr. Andrew Churg of the University of British Colombia and Dr. Maxwell Smith from the Mayo Clinic Arizona. The two international experts on interstitial lung disease (ILD) share their valuable perspective on "where we are and where we need to go" in our approach to the diagnosis and classification of hypersensitivity pneumonitis (HP) and usual interstitial pneumonitis (UIP). 
    21 min

About ModPath Chat

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ModPath Chat is the official podcast of Modern Pathology, the journal of the US and Canadian Academy of Pathology (USCAP). ModPath Chat features interviews with authors, opinion leaders and experts on…