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In this episode of Mohivate, Dr Mohi Sarawgee explores the pineal gland and melatonin, and the ancient system that tells every cell in your body what time it is.

In the 17th century, René Descartes pointed to a single structure buried at the centre of the head, a gland the size of a grain of rice, and called it the seat of the soul. For four hundred years, this tiny gland has drifted between mysticism and medicine. It has been linked to the third eye, to spiritual vision, to “brain sand,” and, more recently, to some genuinely serious neuroscience.

But what is the pineal gland actually doing in there? And why is the hormone it makes, melatonin, so much more than the sleeping pill most of us believe it to be?

From an organ that was once, in our evolutionary past, a literal light-sensing eye, to the darkness signal that governs your sleep, your ageing, your immune system, and even your gut, we follow melatonin’s extraordinary reach across the whole body. We explore why you wake at three in the morning, what blue light really does to your biology, why melatonin sits at the centre of research into Alzheimer’s and cancer, the truth about “decalcifying” the pineal gland, and the honest facts about the supplements sold online.

With clinical insight, a little history, and a personal thread that runs through meditation and stillness, this is an episode about the small gland that keeps time for all of us, and what it means to let the body remember a rhythm it has known for millions of years.

References: 

1. IARC Monographs Vol 124 Group (2019). Carcinogenicity of night shift work. The Lancet Oncology, 20(8), 1058–1059. Night-shift work classified by the WHO/IARC as a probable cause of cancer (Group 2A).

https://doi.org/10.1016/S1470-2045(19)30455-3

2. International Agency for Research on Cancer (2020). IARC Monographs Volume 124: NightShift Work. World Health Organization. The official WHO/IARC source; lists breast, prostate, colon and rectal cancers.

https://www.iarc.who.int/news-events/iarc-monographs-volume-124-night-shift-work/

3. Rhythms of life: melatonin, nutrition, sleep, and antioxidant strategies for healthy aging. Frontiers in Neuroscience, 20:1736978.

https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1736978/full

4. The melatonin–microbiome axis: a new frontier in gut health (2025). Inflammopharmacology.

https://link.springer.com/article/10.1007/s10787-025-02005-4

5. Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis andrhythm disorders (2024). The gut producing far more melatonin than the pineal gland; gut–microbiome interaction.

https://www.nature.com/articles/s41522-024-00605-6

6. Hardeland, R. (2015). Melatonin and brain inflammaging. Progress in Neurobiology.Melatonin declining with age, lower in Alzheimer’s, and its role against brain inflammation.

https://pubmed.ncbi.nlm.nih.gov/25697044/

7. Melatonin as an Anti-Aging Therapy for Age-Related Cardiovascular and Neurodegenerative Diseases (2022). Frontiers in Aging Neuroscience.

https://pmc.ncbi.nlm.nih.gov/articles/PMC9204094/

Just a gentle reminder: this episode is for information, education, and inspiration only. It’s not a substitute for your doctor’s advice. For any personal health concerns, always seek guidance from your doctor.

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In this episode of Mohivate, Dr Mohi Sarawgee explores some of the most confidently repeated health and science myths of the last century. Ideas that were taught in schools, printed on food labels, and handed down through generations as absolute truth, only for the evidence to tell a far more interesting story.

Why did an entire generation grow up being told to eat carrots for better eyesight? Why did low-fat yoghurt end up with more sugar than a dessert? And why did one doctor drink a petri dish to prove a point , and later win a Nobel Prize for it?

From wartime propaganda and the low-fat era that made an entire population less healthy, to the brain myth beloved by every self-help book ever written, and the man who spent sixty years cracking only one hand’s knuckles : this is a lighter episode about curiosity, evidence, and the remarkable ability of science to change its mind when better answers emerge.

Because being wrong is where learning begins.

REFERENCES

1.Ancel Keys, saturated fat, and the dietary guidelines controversy — Newport & Dayrit, Nutrients 2024:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11123895/

2.Barry Marshall, H. pylori, and the Nobel Prize — Nobel Prize official:

https://www.nobelprize.org/prizes/medicine/2005/press-release/

3.Carrots, night vision, and RAF wartime propaganda — World Carrot Museum:

http://www.carrotmuseum.co.uk/ww2seeinthedark.html

4.We only use 10% of our brain — Scientific American debunk:

https://www.scientificamerican.com/article/do-people-only-use-10-percent-of-their-brains/

5.Dr Donald Unger, knuckle cracking, Ig Nobel Prize 2009:

https://pubmed.ncbi.nlm.nih.gov/19922237/

Just a gentle reminder: this episode is for information, education, and inspiration only. It’s not a substitute for your doctor’s advice. For any personal health concerns, always seek guidance from your doctor.

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In this episode of Mohivate, Dr Mohi Sarawgee explores the remarkable story of cinnamon and its connection with metabolic health.
For more than 4,000 years, cinnamon has appeared in ancient Egyptian tombs, Roman history, the Bible, Ayurveda, and Traditional Chinese Medicine. Traders invented elaborate myths to protect it. Entire empires fought over it. At its peak, it was worth more than gold.
Today, it sits  in kitchen cupboards around the world.
But what exactly is cinnamon? And why has modern science only recently started catching up?

In this episode, we explore the history, mythology, and science behind one of the world’s most famous spices. From giant bird nests and snake-guarded valleys to blood sugar, cholesterol, insulin sensitivity, and metabolic health, we follow cinnamon’s extraordinary journey across centuries and continents.

We discuss the difference between Ceylon and cassia cinnamon, what current research tells us about blood sugar control and cholesterol, the potential benefits and limitations of cinnamon supplementation, and the practical questions worth knowing before adding it to your daily routine.

This is a story about trade, medicine, mythology, curiosity, and the remarkable journey of a spice that has fascinated humanity for thousands of years.

Because sometimes the most ordinary things have the most extraordinary histories.

REFERENCES

1.Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med, 2009.
https://pubmed.ncbi.nlm.nih.gov/19734396/
2.Cinnamon supplements may affect medication metabolism — University of Mississippi research, ScienceDaily.
https://www.sciencedaily.com/releases/2025/04/250424165657.htm
3.The effects of cinnamon on patients with metabolic diseases: an umbrella review of meta-analyses, Frontiers in Nutrition, 2025.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12620228/
4.Orally administered cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer’s disease animal models, PLOS ONE, 2011.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030596/
5.Coumarin levels in Ceylon vs cassia cinnamon — assessment in ground cinnamon, PMC.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3385612/

Just a gentle reminder: this episode is for information, education, and inspiration only. It’s not a substitute for your doctor’s advice. For any personal health concerns, always seek guidance from your doctor.

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Why does one person crave rice, another mashed potatoes, and someone else a very specific brand of instant noodles they have not eaten since university?

In this episode of Mohivate, Dr Mohi Sarawgee explores the science and psychology of comfort food. From dopamine and smell to memory, stress, familiarity, and culture, I look at why certain foods have the remarkable ability to make us feel better.

Along the way, there is the Proust effect, the neuroscience of anticipation, why comfort foods differ across cultures yet serve the same emotional purpose, and what happens in the brain when we reach for familiar foods during times of stress or uncertainty.

There is also a detour through some of the stranger stories in food history, from the invention of the Graham cracker to bacon on the moon, and a look at why food has always been about more than nutrition alone.

At its heart, this episode is about familiarity. The foods we return to, the meanings we attach to them, and why certain meals can feel like home long after we have left the places they came from.

Because comfort food is rarely just about what is on the plate. It is about what it represents, what it remembers, and what it helps us find again.

This episode is for anyone who has ever stood in front of an open fridge at midnight. Which is to say, everyone.

REFERENCES

1.Smell, memory, and the brain’s bypass of the thalamus — Harvard Medicine Magazine: https://magazine.hms.harvard.edu/articles/connections-between-smell-memory-and-health

2.Food-related odours and dopaminergic brain activation — Frontiers in Human Neuroscience: https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2017.00625/full

3.Smell and memory pathway (bypassing the thalamus) — Cleveland Clinic: https://health.clevelandclinic.org/smells-and-memory

4.Flavour preferences formed via amniotic fluid and breast milk — BookPage / The Secret History of Food: https://www.bookpage.com/behind-the-book/26562-top-12-weirdest-moments-food-history-history/

The neuroscience of comfort food and individual variation (Yale) — BrainFacts.org: https://www.brainfacts.org/thinking-sensing-and-behaving/diet-and-lifestyle/2023/why-cant-we-resist-comfort-food-080123

6.Cortisol, stress, and cravings for high-fat, high-sugar foods — Time Out: https://www.timeout.com/london/news/the-science-behind-why-comfort-food-is-actually-a-thing-122620

7.Graham cracker history and ketchup/tomato history — LoveFood: https://www.lovefood.com/gallerylist/128759/killer-tomatoes-and-other-strange-historic-food-facts

8.Apollo 11 freeze-dried bacon — Instacart Food Facts: https://www.instacart.com/company/ideas/food-facts

9.Chicken soup, neutrophils, and anti-inflammatory effects — The Conversation: https://theconversation.com/does-chicken-soup-really-help-when-youre-sick-a-nutrition-specialist-explains-whats-behind-the-beloved-comfort-food-213847

10.Comfort food around the world — Diversity Plus: https://diversityplus.com/web/Article.aspx?id=Finding-Comfort-in-Food-Around-the-Globe-5544

Just a gentle reminder: this episode is for information, education, and inspiration only. It’s not a substitute for your doctor’s advice. For any personal health concerns, always seek guidance from your doctor.

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Minoxidil is one of the most recognised treatments for hair loss in the world. Millions of people use it. Few know how it was discovered.

In this episode of Mohivate, I explore the remarkable story of a medication that was never meant to grow hair. What began as a failed ulcer treatment became a powerful blood pressure drug, and an unexpected side effect went on to change dermatology forever.

Along the way, we explore the science of hair growth, why hair loss occurs, the difference between telogen effluvium and androgenetic alopecia, and what minoxidil is actually doing inside the hair follicle. We look at the science behind topical and oral minoxidil, why some people respond dramatically while others do not, the role of sulphotransferase enzymes, shedding, side effects, and what current evidence tells us about combination treatments including microneedling and low-dose oral minoxidil.

But this episode is about more than hair.

Hair loss, like so many things in health, sits at the intersection of biology and identity. It is rarely just about a hairline, a parting, or a reflection in the mirror. It is often about how we see ourselves, how we experience change, and the small things that carry more meaning than we realise.

With science, history, humour, and practical evidence, this episode explores one of medicine's most fascinating accidental discoveries, and why it continues to matter to millions of people around the world.

References:

1. Minoxidil and Its Use in Hair Disorders
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691938/
2. Low-Dose Oral Minoxidil for Alopecia: A Comprehensive Review
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10806356/
3. Efficacy and Safety of Oral Minoxidil in Alopecia: A Systematic Review and Meta-analysis
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188453/
4. Predicting Minoxidil Response Through Follicular Sulfotransferase Activity
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326921/
5. Low-Dose Oral Minoxidil Initiation for Patients With Hair Loss: An International Delphi Consensus Statement
   https://jamanetwork.com/journals/jamadermatology/fullarticle/2826573

Just a gentle reminder: this episode is for information, education, and inspiration only. It’s not a substitute for your doctor’s advice. For any personal health concerns, always seek guidance from your doctor.

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In this episode of Mohivate, Dr Mohi Sarawgee explores one of the most important conversations we rarely have. Death, dying, and what it means to live well until the very end.

The episode begins with a simple observation. Despite being the one certainty every human being shares, death remains one of the least discussed subjects in modern life. Through personal stories, medical insight, and reflections from years in healthcare, she explores why so many families avoid these conversations and why having them may be one of the greatest gifts we leave the people we love.

Along the way, the episode unpacks what palliative care actually is and what it is not. From symptom management and quality of life to the pioneering work of Dame Cicely Saunders and the origin of the modern hospice movement. This episode is a conversation about dignity, compassion, and caring for the whole person.

The episode explores advance care planning, the evidence behind palliative care, and why conversations about our wishes matter long before they become urgent. You will discover how these discussions support families and help people make decisions that reflect what matters most to them.

Woven throughout are stories from clinical practice. Moments of humour, humanity, and wisdom that no textbook can teach. Because dying patients often leave behind some of life’s most important lessons for the living.

At its heart, this episode is not about death. It is about love, legacy, and the conversations that matter. The words we say while we still can. The things we leave behind. And the reminder that a life is not measured by how long it lasts, but by how deeply it touches others.

This episode is shared in fond remembrance of my uncle. 

29.03.1955 - 02.06 2025. Forever missed.

REFERENCES

1.WHO — Palliative Care as a Human Right, World Health Assembly Resolution 2014

https://www.who.int/news-room/fact-sheets/detail/palliative-care

2.Temel et al. 2010 — Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer, New England Journal of Medicine

https://www.nejm.org/doi/abs/10.1056/NEJMoa1000678

3.Temel et al. 2024 — Stepped Palliative Care for Patients with Advanced Lung Cancer, JAMA

https://jamanetwork.com/journals/jama/fullarticle/2819643

4.Tsubaki et al. 2025 — Effects of Advance Care Planning on the Mental Health of Bereaved Families: A Systematic Review, Cureus

https://pmc.ncbi.nlm.nih.gov/articles/PMC12084671/

5.St Christopher’s Hospice — History of Dame Cicely Saunders

https://www.stchristophers.org.uk/about/history

6.Bronnie Ware — The Top Five Regrets of the Dying

https://bronnieware.com/regrets-of-the-dying/

7.Cicely Saunders and the concept of total pain — PMC

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11700540/

Just a gentle reminder: this episode is for information, education, and inspiration only. It’s not a substitute for your doctor’s advice. For any personal health concerns, always seek guidance from your doctor.

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In this episode of Mohivate, Dr Mohi Sarawgee explores one of summer’s most familiar yet misunderstood conditions : Prickly Heat. A rash so common that most of us have experienced it, treated it, or complained about it without ever really understanding what is happening beneath the skin.

The episode begins with the name. Prickly heat is medically known as miliaria, from the Latin word milium, meaning millet. The story travels from Roman physicians who first described it to British soldiers itching their way through India, Southeast Asia, and the Pacific, where the rash became such a military concern that researchers eventually studied it formally in tropical conditions.

The science follows the sweat. From the remarkable efficiency of eccrine sweat glands to what happens when a sweat duct becomes blocked, Dr Mohi explores why prickly heat develops and how skin bacteria can turn a minor irritation into something far more uncomfortable. The three forms of miliaria : Crystallina, Rubra, and Profunda,  are explained clearly, including what each type means, who is most at risk, and when a doctor rather than a pharmacy is the right call.

Practical guidance covers acclimatisation, clothing, skin care, prevention, and treatment, including why the answer has never been an enthusiastic application of powder.

With clinical insight, personal reflection, humour, and a thread that runs beyond the skin itself, this episode asks a simple question: what happens when something designed to flow becomes blocked? Because sometimes the smallest discomforts are simply the body’s way of asking us to pay attention.

This episode gives prickly heat the conversation it has always deserved.

References:

1.Miliaria — StatPearls, National Library of Medicine (2024)

https://www.ncbi.nlm.nih.gov/books/NBK537176/

2.Heat Rash — Mayo Clinic

https://www.mayoclinic.org/diseases-conditions/heat-rash/symptoms-causes/syc-20373276

3.Heat Rash — NHS

https://www.nhs.uk/conditions/heat-rash-prickly-heat/

4.Miliaria — DermNet NZ

https://dermnetnz.org/topics/miliaria

5.Anhydrous Lanolin for Miliaria — Mayo Clinic Treatment Guide

https://www.mayoclinic.org/diseases-conditions/heat-rash/diagnosis-treatment/drc-20373282

Just a gentle reminder: this episode is for information, education, and inspiration only. It’s not a substitute for your doctor’s advice. For any personal health concerns, always seek guidance from your doctor.

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In this episode of Mohivate, Dr Mohi Sarawgee explores one of the most talked about viral health trends of 2026 so far. Women combining an antihistamine and a heartburn tablet to manage menopause symptoms. And asks the question medicine should always ask first. What does the science actually say?

The episode begins with histamine. Not the allergy molecule most people think they know, but a far more versatile chemical messenger with receptors in the gut, the heart, and the brain. From H1 to H2, from mast cells to the oestrogen-histamine feedback loop, this episode unpacks the biology behind the trend with clarity and warmth.

It then explores the relationship between oestrogen and histamine in perimenopause, the role of the DAO enzyme, histamine intolerance as a distinct and underrecognised condition, and why mast cell activation syndrome is not the same as menopause, even when the symptoms overlap.

The honest clinical verdict follows. Including why hot flushes are driven by the neurokinin B pathway and not histamine, what fezolinetant and elinzanetant are and why the UK was the first country in the world to approve the latter, and what HRT and non-hormonal options currently offer women who are struggling.

With clinical insight, personal perspective, and a keen interest in perimenopause and menopause, this episode gives a viral trend the honest conversation it deserves. 

REFERENCES

1.PCOS renamed to PMOS, The Lancet, 12 May 2026

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00717-8/fulltext

2.CNN coverage of the viral menopause trend, May 2026

https://www.cnn.com/2026/05/05/health/menopause-hormones-antacids-antihistamines-wellness

3.Oestrogen and histamine bidirectional relationship

https://pubmed.ncbi.nlm.nih.gov/22651948/

4.Diamine oxidase and oestrogen regulation

https://pubmed.ncbi.nlm.nih.gov/31234240/

5.Histamine intolerance, clinical overview

https://pubmed.ncbi.nlm.nih.gov/30239565/

6.MCAS diagnostic criteria, 

https://www.jacionline.org/article/S0091-6749(24)00569-4/fulltext

7.KNDy neurons and neurokinin B in menopausal hot flushes

https://pubmed.ncbi.nlm.nih.gov/21253695/

8.Fezolinetant, NICE supports NHS prescribing, March 2026

https://thebms.org.uk/2026/03/nice-supports-nhs-prescribing-of-fezolinetant/

9.Elinzanetant, first global approval, MHRA, July 2025

https://www.gov.uk/government/news/mhra-approves-elinzanetant-to-treat-moderate-to-severe-vasomotor-symptoms-hot-flushes-caused-by-menopause

10.Cetirizine withdrawal rebound pruritus, FDA warning 2025

https://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-about-serious-problems-stopping-certain-allergy-medications

Just a gentle reminder: this episode is for information, education, and inspiration only. It’s not a substitute for your doctor’s advice. For any personal health concerns, always seek guidance from your doctor.

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In this special episode of Mohivate, Dr Mohi Sarawgee brings together music, memory, and meaning in the podcast’s first original musical collaboration.
At the heart of this episode is a beautiful piece of music titled The Long Way Home, created by Johan Sebastian Ledesma, who composes under the name Bragei. 

What begins as a chance conversation on an ordinary street becomes something far more unexpected. A story of timing, recognition, and the kind of moments that seem to arrive without being planned, yet feel deeply aligned when they do.

The episode moves through personal memory, from childhood road trips filled with music, to the people who shaped a lifelong relationship with sound, rhythm, and presence. It reflects on how music is not simply something we listen to, but something that holds memory, carries emotion, and connects us across time.

Alongside this, Dr Mohi briefly explores what science understands about music and the brain. From its effects on stress, mood, and the nervous system, to the way it engages multiple regions of the brain at once, music is both deeply felt and biologically significant.

At its heart, this episode is about the moments we do not plan. The ones that arrive through chance encounters, shared interests, and quiet attention. What some might call synchronicity, or serendipity. Moments that shape direction without announcement.
The original piece The Long Way Home plays at the end of this episode, and will be available separately on YouTube for listeners who wish to return to it.
With reflection, story, and collaboration, this episode offers something slightly different. A pause. A memory. And a reminder of the ways we find our way back, often without realising we were looking.

References:

1. Music and the brain — stress, dopamine, and emotional response:
Salimpoor, V.N. et al. (2011). Anatomically distinct dopamine release during anticipation and experience of peak emotion to music. Nature Neuroscience.
https://www.nature.com/articles/nn.2726

2. Music, stress hormones, and the nervous system:
Thoma, M.V. et al. (2013). The effect of music on the human stress response. PLOS ONE.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070156

3. 3. Singing and wellbeing:
Grape, C. et al. (2003). Does singing promote well-being? Integrative Physiological & Behavioral Science.
https://link.springer.com/article/10.1007/BF02734261

Just a gentle reminder: this episode is for information, education, and inspiration only. It’s not a substitute for your doctor’s advice. For any personal health concerns, always seek guidance from your doctor.

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In this episode of Mohivate, Dr Mohi Sarawgee explores screen time in children: the first episode on MOHIVATE dedicated entirely to children, and an honest conversation about what is actually happening inside a child’s developing brain, and what the science is telling us in a world none of us were prepared for.

The episode begins with context. From smartphones and tablets, to a pandemic that made screens the only classroom and playground available, to the first generation of children growing up alongside artificial intelligence as a daily presence. This is the world today’s parents are navigating. Without a guidebook, and largely without support.

The science covers language development, attention and dopamine, sleep and melatonin, the video deficit effect in infants, and the childhood myopia epidemic, including why outdoor light, not eye drops, is the prescription. Age-specific guidance runs from birth through adolescence, including what the research says about social media, cyberbullying, and the teenage brain.

Dr Mohi Sarawgee introduces the Three C’s framework — Content, Context, and Child — a practical lens for families navigating screen time at every age, alongside evidence-based anchors for sleep, eye health, and real life.

With clinical insight, fifteen years of consulting rooms, and a doctor’s deep respect for every parent doing their absolute best, this episode gives screen time the conversation it deserves.

REFERENCES
1. Screen Time and Early Childhood Development
Frontiers in Developmental Psychology — Systematic Scoping Review (2025)
https://www.frontiersin.org/journals/developmental-psychology/articles/10.3389/fdpys.2024.1439040/full
2. Screen Time and Sleep
Hale & Guan — Screen Time and Sleep, Systematic Review, Sleep Medicine Reviews
https://pmc.ncbi.nlm.nih.gov/articles/PMC4437561/
3. Screen Time and Myopia
Ha et al. — JAMA Network Open (February 2025) — 45 studies, 335,524 individuals
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2830598
4. Book by Jonathan Haidt
The Anxious Generation — Research and Evidence Base
https://www.anxiousgeneration.com/research/the-evidence
5. Adolescent Mental Health and Social Media — Dr. Jean Twenge
Research publications and evidence base — Dr. Jean Twenge, San Diego State University
https://www.jeantwenge.com/research/
6. NHS Mental Health of Children and Young People in England (2023)
NHS England Digital — most recent UK data
https://digital.nhs.uk/data-and-information/publications/statistical/mental-health-of-children-and-young-people-in-england/2023-wave-4-follow-up
7. UK Government — Children’s Social Media Consultation (2026)
GOV.UK National Consultation — Growing Up in the Online World
https://www.gov.uk/government/consultations/growing-up-in-the-online-world-a-national-consultation
8. UK Government — Screen Use by Children Under Five (March 2026)
Independent Expert Report — Early Years Screen Time Advisory Group
https://assets.publishing.service.gov.uk/media/69c53daf4a06660f085442a7/EYSTAG_report.pdf

Just a gentle reminder: this episode is for information, education, and inspiration only. It’s not a substitute for your doctor’s advice. For any personal health concerns, always seek guidance from your doctor.