Monoclonal B-cell lymphocytosis (MBL) is a condition characterized by the presence of an abnormal increase in B lymphocytes in the blood. MBL is considered a precursor condition to chronic lymphocytic leukemia (CLL); however, not all cases of MBL progress to CLL, and many individuals with MBL do not require treatment.

In this podcast, Stephen Ansell, MD, PhD, Mayo Clinic, Rochester, MN, Paolo Ghia, MD, Vita-Salute San Raffaele University, Milan, Italy, Andrew Rawstron, PhD, Leeds Teaching Hospitals NHS Trust, Leeds, UK, and Anton Langerak, MD, PhD, Erasmus Medical Center and University, Rotterdam, The Netherlands, discuss the biology, classification, and possible interventions for MBL. This discussion took place at the 2024 Intercepting Blood Cancers Workshop in Lisbon, Portugal.