In this episode of Moral Medicine, Matt shares his experience with Finasteride after taking the drug for several years without issue — and the sudden, life-altering changes that followed.
Matt began taking finasteride in his mid-20s and tolerated the medication for three years with no noticeable side effects. Like many, he believed that if a problem were going to occur, it would happen early.
It didn’t.
One day, everything changed.
What began as a sudden loss of sexual sensation quickly progressed into something far more severe.
Matt describes a rapid and debilitating shift marked by:
• Complete loss of genital sensation and inability to experience orgasm• Severe emotional blunting and anhedonia — a total absence of feeling• Cognitive impairment and disorganized thinking• Chronic physical symptoms including fatigue, pain, and digestive issues• The onset of symptoms worsening after discontinuing the drug
Despite stopping finasteride, these symptoms did not resolve.
Years later, they remain.
Matt opens up about the confusion, isolation, and lack of recognition he faced when trying to understand what had happened — including being reassured that his symptoms were unrelated or psychological.
His experience reflects a pattern reported by others following the use of medications such as Finasteride, Selective Serotonin Reuptake Inhibitors, and Isotretinoin, where individuals describe persistent sexual, neurological, and emotional changes after discontinuation.
While many people take these medications without immediate issue, others report long-term symptoms often referred to as Post-Finasteride Syndrome.
The underlying mechanisms remain unclear, and there is currently no reliable way to predict who may be affected.
Matt’s testimony highlights ongoing concerns around informed consent, delayed onset adverse effects, and the difficulty many patients face when their experiences fall outside of what is widely recognized.
If you or someone you know has experienced persistent symptoms after medication use, you are not alone.
🔬 Research into PFS remains largely patient-funded, but awareness is growing.
📢 If you’ve been affected by PFS, PSSD, or similar post-drug syndromes, your story matters. Reach out at [email protected] to share it.
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🗣 By speaking up, we break the silence and move closer to recognition, accountability, and hope.