In 2014, clinical pharmacist and exercise medicine champion Ann Gates spoke to Jack Chew on The Physio Matters Podcast about the need to reposition physical activity at the centre of healthcare. She described physical inactivity as a public health crisis, advocated for integrating exercise into every patient consultation, and encouraged us to view exercise as a therapeutic agent as legitimate as drugs or surgery.
Nearly 12 years later, the evidence base for exercise medicine has grown substantially and many health systems are increasingly prioritising physical activity in policy and clinical practice. In our first Core Memories feature, we assess how Ann’s insights align with current evidence and thinking in 2026, exploring where her 2014 perspectives have been supported, updated, or reframed by the research.
Exercise as Medicine: Then and Now
2014
Ann framed exercise as being akin to a pharmacological intervention; something that should be prescribed, monitored, and integrated into treatment regimens. She argued that exercise has cost-effectiveness comparable to many drugs and called for healthcare systems to see exercise as an equal partner to traditional medicine.
2026
Ann’s viewpoint has only strengthened with advancing research. Over the past decade, multiple large-scale meta-analyses and clinical guidelines have solidified what earlier researchers hinted at: exercise has measurable effects on morbidity and mortality across a range of chronic conditions.
For example:
Cardiometabolic disease: In secondary prevention and some high-risk groups, structured exercise interventions can achieve mortality outcomes comparable to drug therapy in the evidence base, and exercise-based programmes (e.g. cardiac rehabilitation) reduce cardiovascular mortality and recurrent events, though effects on all-cause mortality are more variable in contemporary trials [1,2].
Type 2 diabetes: For type 2 diabetes, physical activity is firmly positioned as a foundational component of management rather than optional advice. Contemporary NICE and American Diabetes Association guidance places structured exercise alongside pharmacotherapy from diagnosis, recognising its role in improving insulin sensitivity, lowering HbA1c (a blood test that measures blood glucose levels over the past three months), and reducing cardiovascular risk [3,4]. Meta-analyses consistently show that aerobic, resistance and combined training meaningfully reduce glycaemic markers, with combined approaches often producing the greatest benefit [5,6]. While exercise does not replace medication for most patients, it can reduce medication burden in some cases and remains one of the most powerful long-term cardiometabolic interventions available [7].
Cancer survivorship: Exercise is now embedded within survivorship care in many oncology pathways, with international guidelines recommending structured aerobic and resistance training following treatment [8,9]. Level-1 evidence, including large randomised trials such as the CHALLENGE study in colon cancer survivors, demonstrates reduced recurrence risk alongside improvements in quality of life and physical function [10]. Across tumour types, systematic reviews consistently confirm exercise as a safe, effective adjunct in post-treatment care [11].
Health organisations and clinical initiatives (e.g. Exercise is Medicine/ACSM and NHS England-aligned programmes) increasingly treat physical activity as a “vital sign” assessed in routine consultations and linked to actionable goals [12–14]. Ann’s view that exercise should be monitored like a drug has gained traction in clinical pathways and electronic medical records, where best practice is for physical activity metrics to be charted alongside markers such as blood pressure and blood glucose, although adoption remains variable.
Conclusion
The core premise of exercise medicine articulated in 2013 has been reinforced and operationalised. In 2026, it is not just progressive advocacy but a mainstream clinical priority in many healthcare systems.
Brief Interventions and ‘Making Every Contact Count’
2014
Ann emphasised brief, teachable moments within consultations: short but confident advice linking exercise to measurable health outcomes. She cautioned against treating exercise advice as a quick fix and advocated for monitoring and follow-up analogous to pharmacotherapy.
2026
This approach aligns closely with contemporary behavioural science and implementation research. Brief physical activity interventions delivered in primary care have demonstrated modest but clinically meaningful increases in activity levels, particularly when combined with goal-setting and follow-up support [15,16]. Even very short conversations, often under two minutes, can prompt behaviour change when paired with structured referral pathways or digital reinforcement [16,17].
Making Every Contact Count remains a valid and widely endorsed model within UK public health strategy [18], though modern implementation increasingly incorporates digital systems — including patient portals, remote monitoring, wearable data integration and automated messaging — to improve adherence and clinician follow-through [19].
Importantly, systematic reviews confirm a point Ann anticipated: brief advice alone is usually insufficient unless embedded within wider behaviour-change systems that include ongoing support, environmental accessibility and tailored feedback [15,20].
Current nuance
Recent work in behavioural medicine emphasises contextual tailoring; interventions are most effective when adapted to readiness to change, health literacy, socioeconomic context and cultural background [20,21].
Conclusion
Ann’s 2014 framing of brief, confident, monitored interventions anticipated current best practice. In 2026, the principle remains sound but effectiveness increasingly depends on structured follow-up and digitally enabled support systems.
Healthcare Systems, Barriers, and Equity
2014
Ann argued that healthcare systems were poorly designed to promote exercise, stressing the need for community links, clinician empowerment, and breaking down barriers that prevent physical activity.
2026
Subsequent policy frameworks increasingly reflect this thinking. The last five years have seen:
* Inclusion of physical activity targets within national strategies, including NHS Long Term Plan delivery updates and the UK Chief Medical Officers’ physical activity framework, which position prevention and activity promotion as core system priorities [22,23].
* Growth of community-linked referral schemes, including social prescribing pathways and exercise referral programmes designed to connect patients with local activity providers through primary care networks [24,25].
* Greater integration of social determinants of health into physical activity policy, with recognition that access to safe environments, green space, transport infrastructure and socioeconomic stability significantly influence participation [23,26].
However, implementation remains uneven. Despite national ambition, regional variation in service availability and infrastructure persists, and disparities in access to community programmes continue to reflect the “postcode lottery” Ann described [24,27].
A notable evolution over the past decade has been a sharper focus on health equity. Research consistently demonstrates disparities in physical activity participation by ethnicity, gender, age, disability and deprivation [26,28]. In response, targeted programmes — particularly those addressing adolescent girls, older adults and underserved communities — have demonstrated improved engagement and adherence when culturally and contextually tailored [28,29].
Conclusion
Ann’s 2014 critique of structural barriers remains valid. By 2026, however, policy frameworks are more explicitly equity-oriented and data-driven, even if delivery across systems remains inconsistent.
Research Gaps and Implementation Science
2014
Ann challenged researchers to produce rigorous trials comparing exercise interventions with other treatments and highlighted deficits in long-term follow-up.
2026
Over the past decade, research quality in exercise medicine has improved substantially. Large pragmatic trials now more commonly incorporate structured, standardised exercise protocols aligned with public health guidance, including aerobic volumes consistent with 150+ minutes per week and inclusion of resistance training components [30,31].
There has also been a marked rise in implementation science within physical activity research, focusing not only on efficacy but on scalability, system integration and real-world translation into primary and secondary care pathways [32,33]. Longer-term follow-up has become more common, with several contemporary trials and cohort extensions reporting outcomes beyond two to five years, addressing earlier concerns that exercise research relied too heavily on short-duration endpoints [34].
That said, important gaps remain. Head-to-head comparative trials between structured exercise prescriptions and procedural or invasive interventions are still relatively uncommon outside selected cardiology and oncology contexts [35]. While funding streams and international collaborations in exercise oncology and cardiometabolic health are expanding, coordinated multi-site interdisciplinary exercise medicine research remains underdeveloped compared with pharmaceutical research infrastructures [32,36].
Conclusion
Exercise medicine research is more rigorous and implementation-focused than it was in 2014. However, comparative trials and large-scale coordinated funding still trail behind other treatment areas. The evidence is stronger, but system-level integration remains incomplete.
Final Reflections
Looking back from 2026, many of Ann Gates’ perspectives from 2014 not only stood the test of time but anticipated future developments in clinical practice, research and health system design. Exercise medicine is now more embedded in routine care, brief interventions are backed by behavioural science and equity has become a central concern.
We asked Ann for her thoughts on relistening to the podcast:
“Revisiting that 2014 conversation on The Physio Matters Podcast, I’m struck by how consistent the core message remains: movement is powerful medicine. The evidence base has only strengthened over the past decade. What has evolved is our understanding of implementation and scale.
Brief advice is well evidenced, and approaches such as Make Every Contact Count have rightly embedded physical activity within routine care. But advice achieves its greatest impact when the system around it supports and sustains behaviour change.
Professional education, service design, leadership priorities and community environments determine whether movement becomes normalised or remains dependent on individual advocacy.
The next critical step is strengthening our collective change agency — redesigning healthcare so prevention is structurally embedded, aligned with the systems approach set out in the World Health Organisation’s Global Action Plan on Physical Activity.
Movement should be a mainstay in prevention, treatment and rehabilitation of ill health across the life course. The science is clear. The responsibility now is collective.”
Our collective responsibility is clear. The vision of universally integrating exercise into every consultation, ensuring consistent access to supportive community resources and developing robust comparative evidence remains a work in progress. The conversation Ann started over a decade ago continues to shape how clinicians view physical activity — not as an optional extra, but as medicine with profound, evidence-based impact.
References
* Naci H, Ioannidis JPA. Comparative effectiveness of exercise and drug interventions on mortality outcomes: meta-epidemiological study. BMJ. 2013;347:f5577. doi:10.1136/bmj.f5577.
* Dibben GO, Faulkner J, Oldridge N, Rees K, Thompson DR, Zwisler AD, Taylor RS. Exercise-based cardiac rehabilitation for coronary heart disease: a meta-analysis. Eur Heart J. 2023;44(6):452-469. doi:10.1093/eurheartj/ehac747.
* National Institute for Health and Care Excellence (NICE). Type 2 diabetes in adults: management (NG28). London: NICE; Updated 2026.
* American Diabetes Association. Standards of Care in Diabetes—2026. Diabetes Care. 2026.
* Pan B, Ge L, Xun YQ, et al. Exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis. Diabetes Care. 2018;41(12):2431-2439.
* Umpierre D, Ribeiro PAB, Kramer CK, et al. Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: systematic review and meta-analysis. JAMA. 2011;305(17):1790-1799.
* Look AHEAD Research Group. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369:145-154.
* Campbell KL, Winters-Stone KM, Wiskemann J, et al. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Med Sci Sports Exerc. 2019;51(11):2375-2390.
* National Institute for Health and Care Excellence (NICE). Cancer rehabilitation and survivorship guidance. London: NICE.
* Courneya KS, Booth CM, Gill S, et al. Effects of a structured exercise program on disease-free survival in colon cancer survivors: the CHALLENGE randomized trial. N Engl J Med. 2024/2025.
* Segal R, Zwaal C, Green E, et al. Exercise for people with cancer: systematic review and clinical practice guideline. Curr Oncol. 2017;24(1):40-46.
* Sallis R. Exercise is medicine and physicians need to prescribe it. Br J Sports Med. 2009;43:3-4.
* World Health Organization. WHO Guidelines on Physical Activity and Sedentary Behaviour. Geneva: WHO; 2020.
* NHS England. Physical Activity Vital Sign. NHS Data Dictionary. 2024.
* Orrow G, Kinmonth AL, Sanderson S, Sutton S. Effectiveness of physical activity promotion based in primary care: systematic review and meta-analysis. BMJ. 2012;344:e1389.
* O’Brien N, McDonald S, Araujo-Soares V, et al. The effectiveness of physical activity interventions in primary care: systematic review. Br J Sports Med.
* National Institute for Health and Care Excellence (NICE). Behaviour change: individual approaches (PH49). London: NICE.
* NHS England. Making Every Contact Count (MECC). London: NHS England.
* World Health Organization. WHO guideline: recommendations on digital interventions for health system strengthening. Geneva: WHO.
* Michie S, van Stralen MM, West R. The behaviour change wheel: a new method for characterising and designing behaviour change interventions. Implement Sci. 2011;6:42.
* Marteau TM, Hollands GJ, Fletcher PC. Changing human behaviour to prevent disease. BMJ. 2012;345:e6453.
* NHS England. The NHS Long Term Plan. London: NHS England; 2019.
* UK Chief Medical Officers. Physical Activity Guidelines. London: Department of Health; 2019.
* NHS England. Social prescribing and community-based support: summary guide. London: NHS England.
* Public Health England. Exercise Referral Schemes: A National Evaluation. London: PHE.
* World Health Organization. Global Action Plan on Physical Activity 2018–2030. Geneva: WHO.
* Sport England. Active Lives Survey. London: Sport England.
* World Health Organization. Fair Play: Building a Strong Physical Activity System for More Active People. Geneva: WHO; 2024.
* Sport England. This Girl Can campaign evaluation reports. London: Sport England.
* World Health Organization. Guidelines on physical activity and sedentary behaviour. Geneva: WHO; 2020.
* American College of Sports Medicine. ACSM’s Guidelines for Exercise Testing and Prescription. 11th ed. Philadelphia: Wolters Kluwer; 2021.
* Glasgow RE, Harden SM, Gaglio B, et al. RE-AIM planning and evaluation framework: adapting to new science and practice with a 20-year review. Front Public Health. 2019.
* World Health Organization. Global Action Plan on Physical Activity 2018–2030: implementation framework. Geneva: WHO.
* Look AHEAD Research Group. Eight-year weight losses with an intensive lifestyle intervention: the Look AHEAD study. Obesity. 2014.
* Naci H, Ioannidis JPA. Comparative effectiveness research of exercise versus drug interventions: methodological perspectives. BMJ.
* Sallis R, Pratt M. Physical activity as a global health priority: scaling Exercise is Medicine. Br J Sports Med.
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