With cases from Dr James Noake
In musculoskeletal medicine, we are trained to recognise patterns. Most of the time, the answer sits comfortably within the familiar: overload, strain, tendinopathy. But every so often, something doesn’t quite fit. The story is slightly off, the response to treatment unexpected, or the clinical picture just a little too inconsistent.
This is where the ‘Zebra Farm’ comes in.
Each time, we explore a trio of real-world cases as written up by Dr James Noake (Consultant in Musculoskeletal, Sport and Exercise Medicine) in his upcoming book ‘Real World Sports Medicine and Musculoskeletal Case Studies : Knee and Lower Leg’. The cases challenge diagnostic instinct; presentations that look routine on the surface but reveal something far less obvious underneath. These are not just rare conditions for rarity’s sake; they are reminders of the cognitive traps we all fall into: anchoring, pattern recognition bias, and premature closure.
Because sometimes, when you hear hoofbeats, it isn’t a horse.
This is the Zebra Farm.
Case 1: The ‘Compartment Syndrome’ That Wasn’t - Myotonia Congenita
A runner and footballer in their late 20s had endured a 10-year history of bilateral lower leg pain, described as ‘crampy’ and ‘bursting’.
Everything pointed toward chronic exertional compartment syndrome (CECS):
* Rapid symptom onset with running
* Involvement of multiple compartments (anterior worst)
* Stiffness and subjective weakness after activity
They had even undergone bilateral fasciotomies with no improvement.
Something didn’t add up
On reassessment:
* Muscles felt ‘woody’ and rigid post-exercise
* There was increased muscle tone noted and delayed muscle relaxation
* Power improved paradoxically with repeated effort
* MRI showed diffuse calf oedema bilaterally, but nothing focal
The crucial clue came from EMG:
* Myotonic discharges producing a classic ‘dive-bomber’ sound
* Further testing showed mild changes in the deltoid too
Diagnosis: Myotonia Congenita
A non-dystrophic neuromuscular disorder - not a compartment problem at all.
Why it fooled everyone
* The patient looked ‘muscular’ (due to doing isometrics 24/7 for 10 years…)
* Imaging looked ‘consistent’ with exertional pathology
* Long history reinforced diagnostic anchoring
Key sign
➡️Symptoms didn’t fully settle after stopping exercise and they improved with repetition (warm-up phenomenon). Note though that this warm up phenomenon is short lived!
Transition: When ‘muscle pain’ isn’t muscle at all
The first case teaches us that abnormal muscle physiology can masquerade as mechanical overload.
The next case pushes this even further: when the pain isn’t muscular at all, but vascular.
Case 2: The ‘Nerve Entrapment’ That Was a Clot - Peroneal Vein Thrombosis
A patient in their 40s presented with 3 months of deep lateral calf aching:
* Worse with activity—but now present at rest and at night
* Localised toward the lateral calf
* Referred as possible superficial peroneal nerve entrapment
They also had a significant history:
* Prior contralateral DVT
* Avascular necrosis of the hip
The imaging changed everything
MRI neurography revealed:
* Marked oedema in the flexor hallucis longus region
* Oedema centred around the peroneal vessels
This raised suspicion of something non-mechanical.
➡️ Duplex ultrasound confirmed a peroneal vein thrombosis
Diagnosis: Deep vein thrombosis mimicking MSK pain
Why it fooled clinicians
* Localised lateral calf pain suggested nerve pathology
* Gradual onset, not acute
Key sign
➡️ Pain that progresses from activity-related to constant, especially with night pain, should raise suspicion
Bigger picture
This case also highlights underlying systemic risk:
* With recurrent thrombosis and AVN, consider possible antiphospholipid syndrome / Systemic lupus erythematosus (SLE)
Transition: When imaging is subtle - but the symptoms are loud
The first case was metabolic.The second was vascular.
The third returns to muscle but challenges our understanding of what a ‘muscle injury’ actually looks like.
Case 3: The ‘Imminent Tear’ - Soleus Central Tendon Injury
A runner presented with:
* 3 months of deep mid-calf aching
* Described repeatedly as an ‘imminent tear’ sensation following cramping
* No single traumatic event
* Performance and speed limited and runner has to pull up and stop when symptoms appear
Clinical pattern
* Low-level activity: manageable
* Threshold reached → sudden escalation of pain
* No bruising, no classic tear presentation
Imaging findings
* Ultrasound: Soleus central tendon injury with loss of definition and subtle hypoechoic changes
* MRI: central tendon (aponeurotic) disruption within the soleus
Diagnosis: Soleus central tendon injury
Why it fooled clinicians
* No ‘pop’ or obvious tear
* Minimal early clinical signs
* Ultrasound sensitivity is poor (~27%)
* Symptoms felt disproportionate to findings
Key sign
➡️ Deep, progressive calf pain with a ‘threshold’ or ‘pre-tear’ sensation - without trauma
Closing Reflection: Patterns That Should Make You Pause
These three cases highlight a shared clinical truth:
When the pattern doesn’t behave like a simple strain, it probably isn’t.
Across all three:
* Symptoms persisted beyond expected timelines
* Pain behaviour was atypical
* Initial diagnoses seemed plausible - but incomplete
The real challenge isn’t recognising rare diagnoses, it’s recognising when a common diagnosis no longer fits.
Practical Takeaways
Red flags in ‘routine’ calf pain
* Night pain or symptoms at rest
* Bilateral or multi-compartment involvement
* Long-standing symptoms with failed standard treatment
* Disproportionate stiffness or muscle tone
* Neurological or systemic history
Think beyond muscle when:
* Symptoms don’t resolve after rest (≠ CECS pattern)
* Pain improves with repetition but only for a short time (→ myotonia)
* Symptoms progress despite offloading
* Pattern is inconsistent with imaging
Always consider alternatives:
* Neuromuscular → myotonia, metabolic myopathies
* Vascular → DVT, post-thrombotic syndrome
* Aponeurotic/tendon → deep muscle architecture injuries
Clinical mindset shift
* Don’t anchor on the first ‘reasonable’ diagnosis
* Reassess when treatment fails
* Let pain behaviour, not just imaging, guide your thinking
In MSK medicine, the sound of hooves is usually a horse.
But in calf pain- it’s just often enough a zebra to matter.
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