November 12, 2025: Bracket Dom of Bracketometry.com is America's number one rated bracketologist and weighs in with his early season top 4 seed lines for each region. Dom Ranks the power conferences and top 4 seed lines in all four regions.

Conferences: Big Ten, Big 12, SEC, ACC, Big East

1 - Houston, Purdue, Louisville, Alabama 2 - Duke, UConn, Arizona, Illinois 3 - Kentucky, Florida, St. John's, Michigan 4 - Michigan State, Gonzaga, UCLA, BYU

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