In this episode of Updates in Anesthesiology, Dr. Hadzic reviews the newly published 2025 international clinical practice guidelines on platelet transfusion, co-led by Dr. Ryan Metcalf from the University of Utah and Dr. Simon Stanworth from Oxford, and published in JAMA. Based on evidence from over 30 studies, these guidelines recommend restrictive platelet transfusion thresholds in both adult and pediatric populations, advocating for transfusions only when platelet counts are critically low in specific scenarios. The goal? Minimize unnecessary transfusions, reduce patient harm, and conserve resources without increasing bleeding or mortality.

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