IMPACT Collaboratory PI Vince Mor speaks with Jason Karlawish, MD about his recent IMPACT Collaboratory Grand Rounds presentation on Modifications and Waivers of Informed Consent in Pragmatic Clinical Trials. Karlawish, Professor of Medicine, Medical Ethics and Health Policy, and Neurology, and Co-Director of the Penn Memory Center at University of Pennsylvania, focuses his research on issues at the intersections of bioethics, aging and the neurosciences.