When I first discovered Synapse Medicine, I was fascinated by the depth of work they had done to handle prescriptions and clinical decision support in their system.  Since their system was and is being broadly used in France, they were able to see and work on all the problems associated with medication management and discover the solutions that worked across a wide swath of patients and environments.  Needless to say, there's more to prescription management and medication decision support than you would expect at first glance.