Notable Nobels

This episode covers one half of the 2008 Nobel Prize in Physiology or Medicine, which was awarded to Harald zur Hausen. The Nobel Assembly at the Karolinska Institute chose to give zur Hausen the award “for his discovery of human papilloma viruses causing cervical cancer”. Topics include the use of Pap smears to screen for cervical cancer, zur Hausen’s discovery of HPV DNA in cervical cancer cells, and the development of highly effective HPV vaccines.

This episode covers one half of the 2008 Nobel Prize in Physiology or Medicine, which was awarded to Luc Montagnier and Françoise Barré-Sinoussi. The Nobel Assembly at the Karolinska Institute chose to give Montagnier and Barré-Sinoussi the award “for their discovery of human immunodeficiency virus”. Topics include how the AIDS pandemic unfolded at the start of the 1980s, the work scientists did to discover the virus behind the pandemic, the ongoing search for an HIV vaccine, and some of the novel strategies scientists are testing to find a cure for HIV infections.

This episode covers the 1975 Nobel Prize in Physiology or Medicine, which was awarded to David Baltimore, Renato Dulbecco, and Howard Temin. The Nobel Assembly at the Karolinska Institute chose to give Baltimore, Dulbecco, and Temin the award “for their discoveries concerning the interaction between tumor viruses and the genetic material of the cell”. Topics include the identification of Rous Sarcoma Virus as the first known retrovirus, the discovery of an enzyme called reverse transcriptase that can synthesize a DNA copy of a molecule of RNA, and how reverse transcriptase has become an essential tool for solving some of biology’s biggest problems.

This episode covers the 1989 Nobel Prize in Physiology or Medicine, which was awarded to J. Michael Bishop and Harold Varmus. The Nobel Assembly at the Karolinska Institute chose to give Bishop and Varmus the award “for their discovery of the cellular origin of retroviral oncogenes”. Topics include Bishop and Varmus’ discovery of the first cellular proto-oncogene c-src, how the discovery of that gene lead to a fundamental shift in our understanding of the essence of cancer, and Beowulf.

This episode covers one half of the 1966 Nobel Prize in Physiology or Medicine, which was awarded to Peyton Rous. The Nobel Assembly at the Karolinska Institute chose to give Rous the award “for his discovery of tumor-inducing viruses”. Topics include Rous’ discovery of a virus that caused cancer in chickens, how that sparked a search for cancer-causing viruses in humans, and the discovery of Epstein-Barr virus, the first virus linked to a human cancer. 

This episode covers the 1954 Nobel Prize in Physiology or Medicine, which was awarded to John Enders, Thomas Weller, and Frederick Robbins. The Nobel Assembly at the Karolinska Institute chose to give Enders, Weller, and Robbins the award “for their discovery of the ability of poliomyelitis viruses to grow in cultures of various types of tissue”. Topics include the work that culminated in the creation of the Salk and Sabin polio vaccines, the nearly completed mission to eradicate polio from the face of the earth, and the reason Franklin D. Roosevelt’s portrait is on the American dime. 

This episode covers the 1951 Nobel Prize in Physiology or Medicine, which was awarded to Max Theiler. The Nobel Assembly at the Karolinska Institute chose to give Theiler the award “for his discoveries concerning yellow fever and how to combat it”. Topics include the discovery that yellow fever is spread by mosquitos, the discovery that yellow fever is caused by a virus, and how Theiler was able to create a live-attenuated vaccine for yellow fever that we still use today.  

This episode covers the 1948 Nobel Prize in Physiology or Medicine, which was awarded to Paul Hermann Müller. The Nobel Assembly at the Karolinska Institute chose to give Müller the award “for his discovery of the high efficiency of DDT as a contact poison against several arthropods”. Topics include the use of DDT to control the spread of insect-borne diseases, the creation of the United States CDC and the Environmental Protection Agency, and bacteria that prevent mosquitos from spreading dengue virus.

This episode covers the 1952 Nobel Prize in Physiology or Medicine, which was awarded to Selman Waksman. The Nobel Assembly at the Karolinska Institute chose to give Waksman the award “for his discovery of streptomycin, the first antibiotic effective against tuberculosis”. Topics include the isolation of streptomycin, how antibiotics work molecularly, and the growing problem of antibiotic-resistant bacteria.

This episode covers the 1945 Nobel Prize in Physiology or Medicine, which was awarded to Alexander Fleming, Ernst Chain, and Howard Florey. The Nobel Assembly at the Karolinska Institute chose to give Fleming, Chain, and Florey the award “for the discovery of penicillin and its curative effect in various infectious diseases”. Topics include Fleming’s completely accidental discovery of penicillin, how Chain and Florey turned penicillin into a global wonder drug, and some of the properties of a good antibiotic.