One Health Wednesdays highlights work in One Health to encourage awareness, solutions, and professional development. Dr. Julia Zammit and Dr. Thomas Julian Irabor share their work in Game Based Learning 4, or GBL4 to use game-based learning to tackle antibiotic resistance and other issues in One Health. They describe how the group’s process of integrating systems-thinking principles, subject matter expertise in calf mortality, and in-game data collection offers a unique way to educate communities and understand barriers to change.