Opioid-free anesthesia sounds appealing, but does it actually improve outcomes? In this episode, we discuss the main findings from a clinical focus review in Anesthesiology by Shanthanna et al. and discuss why avoiding opioids altogether may add complexity without clear benefit. The real win isn’t “opioid-free,” it’s opioid-sparing, procedure-specific, and regional-first anesthesia. Evidence over ideology.

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