Out of This World — The Podcast

[JOURNAL · Deep Dive] A single psilocybin session triggers a 10% increase in dendritic spine density within 24 hours. The structural brain changes persist for weeks. Here is the neuroscience behind what researchers now call the most significant plasticity finding in psychiatry.

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[JOURNAL · Narration] Anorexia nervosa carries the highest mortality rate of any psychiatric disorder. For the first time, clinical science is showing that psilocybin may address the very mechanisms that make it so difficult to treat.

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[JOURNAL · Narration] MDMA floods the brain with serotonin, triggers a surge of oxytocin, and silences the amygdala’s threat response — simultaneously. Two Phase 3 trials have now tested what this neurochemical state enables for treatment-resistant PTSD.

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[JOURNAL · Narration] Grief is supposed to end. For 7–10% of bereaved individuals, it does not — it becomes prolonged grief disorder, a locked neural state of yearning and avoidance that resists conventional treatment. Clinical trials suggest psilocybin can break that lock. Here is what the evidence shows.

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———

🌌 Explore the Out of This World ecosystem

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[JOURNAL · Deep Dive] Grief is supposed to end. For 7–10% of bereaved individuals, it does not — it becomes prolonged grief disorder, a locked neural state of yearning and avoidance that resists conventional treatment. Clinical trials suggest psilocybin can break that lock. Here is what the evidence shows.

Read the full article

———

🌌 Explore the Out of This World ecosystem

🛸 OOTW Mission Control — the brand home for our nine wellness initiatives

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[JOURNAL · Narration] For 7 to 10 percent of bereaved individuals, grief does not end — it loops. A DMN prediction machine that cannot update. Here is the neuroscience of why psilocybin may help the brain complete what cannot be forced.

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———

🌌 Explore the Out of This World ecosystem

🛸 OOTW Mission Control — the brand home for our nine wellness initiatives

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[JOURNAL · Deep Dive] For 7 to 10 percent of bereaved individuals, grief does not end — it loops. A DMN prediction machine that cannot update. Here is the neuroscience of why psilocybin may help the brain complete what cannot be forced.

Read the full article

———

🌌 Explore the Out of This World ecosystem

🛸 OOTW Mission Control — the brand home for our nine wellness initiatives

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[JOURNAL · Narration] OCD is not a thought problem. It is a circuit problem. The cortico-striatal loop generates an error signal it cannot terminate. Three clinical trials have now tested what happens when psilocybin is introduced into that loop.

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🌌 Explore the Out of This World ecosystem

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[JOURNAL · Narration] When a terminal diagnosis arrives, existential terror can become as incapacitating as the disease itself. Two landmark trials in 2016 changed everything we thought we knew about dying — and the data has held for four and a half years.

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🌌 Explore the Out of This World ecosystem

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[JOURNAL · Narration] Post-traumatic stress disorder is not a memory problem — it is a fear extinction failure. The brain learned to fear and forgot how to unlearn. New clinical trials are testing whether psilocybin can restore what trauma took away.

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———

🌌 Explore the Out of This World ecosystem

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