Only about 50% of patients with chronic diseases adhere to treatment recommendations, and the consequences can be devastating. In this thought-provoking episode of the ESVS Podcasts, we delve into this important and under-discussed issue. Together with Professor Khadija Hafidh, we analyse some factors that help explain why so many patients struggle with adherence, as well as some strategies that have proved effective in improving patient compliance. Spoiler: empathy, communication, shared decision making, and simplifying the treatment regime are key elements. Join us in this episode that can really help your clinical practice.