Antimicrobial stewardship programs (ASP) are recognized as apt measures for effective antimicrobial use and for promoting patient safety in adult care settings. Recent research indicates these programs may be applicable in pediatrics. Theo Zaoutis, MD, and Talene Metjian, PharmD, leaders of the ASP at the Children’s Hospital of Philadelphia, join host Dr. Charles Turck. Can ASPs optimize clinical outcomes related to antimicrobial use?