Pediatrics

Host: Alka Goyal, MD

Higher Postinduction Infliximab Serum Trough Levels Are Associated With Healing of Fistulizing Perianal Crohn’s Disease in Children.

Wael El-Matary, MD, MSc Thomas D Walters, MD Hien Q Huynh, MDJennifer deBruyn, MD David R Mack, MD Kevan Jacobson, MD Mary E Sherlock, MDPeter Church, MD Eytan Wine, MD, PhD Matthew W Carroll, MD, Eric I Benchimol, MD, PhD Sally Lawrence, MD Anne M Griffiths, MD

Background:

There is some evidence in adults that higher serum infliximab (IFX) levels are needed to adequately treat fistulizing perianal Crohn's disease (CD). However, data in children are lacking. We aimed to determine postinduction serum trough IFX levels that are associated with healing of fistulizing perianal CD (PCD) at week 24.

Methods:

In a multicenter inception cohort study, consecutive children younger than age 17 years with fistulizing perianal CD treated with IFX between April 2014 and June 2017 who had serum trough IFX titers measured before the fourth infusion were included. Area under the receiver operating characteristic curve (AUROC) was calculated to determine the best cutoff to predict fistula …

Host: Brian P. McDonough, MD, FAAFP

Guest: Teresa Gil, PhD

Since about 21 million mothers in America experienced sexual abuse in their childhood, there’s a good chance that some of these women are our patients. So as their physicians, how can we provide them with the best possible care as they continue to cope with the lifelong effects of sexual abuse? That’s what Dr. Brian McDonough explores with Dr. Teresa Gil, author of Women Who Were Sexually Abused as Children: Mothering, Resilience, and Protecting the Next Generation.

Host: Andrew Wilner, MD, FACP, FAAN

As physicians, we know that vaccines help protect people from preventable diseases, but somehow this message is getting lost among our patients. With more parents than ever choosing to skip the needle, Dr. Andrew Wilner dives into the 16th chapter of his book, Bullets and Brains, where he discusses the widespread benefits of vaccines and how they not only protect your patients’ children, but all of us.

Host: Athos Bousvaros, MD, MPH

Guest: Andrew B. Grossman, MD

Recorded at the second annual Crohn’s & Colitis Congress in Las Vegas, Dr. Athos Bousvaros and Dr. Andrew Grossman discuss IBD among pediatric patients and how optimizing various therapies is critically important to achieving disease remission.

Host: Andrew Wilner, MD, FACP, FAAN

Up until 2011, there was no FDA-approved antivenom for scorpion stings—until a very concerned pediatrician created one that came with seemingly miraculous results. Dr. Andrew Wilner breaks down this overlooked health threat and the development of its antivenom, which he explores in his book of essays called Bullets and Brains.

Host: Jennifer Caudle, DO

August is National Immunization Awareness Month sponsored by the National Public Health Information Coalition. Dr. Jennifer Caudle discusses the important role immunizations play in healthcare.

Host: Jennifer Caudle, DO

Guest: Sarah E. Domoff, PhD

To address the growing issue of prolonged screen time and media use among children, Dr. Jennifer Caudle speaks with Dr. Sarah Domoff, Director of the Family Health Lab at Central Michigan University, about the tools available to help physicians identify and curb screen addiction.

Host: Brian P. McDonough, MD, FAAFP

Guest: Tanya Altmann, MD

To investigate the concerning rise in both asthma and allergies in children, Dr. Brian McDonough is joined by Dr. Tanya Altmann, pediatrician and Editor in Chief of the American Academy of Pediatrics parenting books, to discuss why a missing component of the gut microbiome may be the potential cause and how nutrition and probiotics play a vital role in a child's growth and development.

Host: Jennifer Caudle, DO

Guest: Jean Bennett, MD, PhD

Guest: Albert Maguire, MD

Power couple Drs. Jean Bennett and Albert Maguire discuss how their new therapy for the RPE65 gene, which causes retinal blindness, was recently approved by the FDA to become the first gene therapy treatment for a genetic disease in the United States and the first worldwide treatment for inherited blindness. Not only do they delve into the mechanics of the corrected gene injection, but they also explain what this milestone means for patient eligibility and how their marriage has played a role in the success of their research partnership.

Dr. Jean Bennett is the F.M. Kirby Professor of Ophthalmology at the Perelman School of Medicine at the University of Pennsylvania, and Dr. Albert Maguire is a Professor of Ophthalmology at the Hospital of the University of Pennsylvania and Attending Physician in the Division of Pediatric Ophthalmology at Children’s Hospital of Philadelphia.

Host: Philip Stein, MD

Guest: Neilanjan Nandi, MD

Guest: Susan Peck, MSN, CRNP

From the ReachMD studios in Fort Washington, Pennsylvania, host Dr. Philip Stein talks with Dr. Neilanjan Nandi and nurse practitioner Susan Peck about their respective experiences with The Crohn’s & Colitis Foundation's Camp Oasis. This camp gives children with IBD the opportunity to meet other kids with the same chronic illness, teaching them how to cope with their disease, manage their own medical needs, try new sports and activities, build confidence and independence, and most importantly, spend quality time just being a kid.