Penny tries to figure out what her feelings for Leonard are, since she is happy with their relationship, yet she is unsure if she is in love just yet. She confides in Bernadette and Amy about the matter, which results in Amy telling Sheldon about it. Sheldon, out of concern for Leonard and his hatred for changes, tries to talk Penny into maintaining her relationship with Leonard. Meanwhile, Raj finds a new friend in Stuart, to fill the void left by Howard, and Stuart gets accepted into their social group by Sheldon, so long as he behaves as Howard would. Howard meanwhile, gets bullied by his fellow astronauts.

On the occasion of the second anniversary of their first date Sheldon and Amy celebrate, however a lonely Raj is invited by Sheldon to join them. Amy is quite upset by Sheldon's actions. She also demands to know what is in his heart and gets a romantic soliloquy by Sheldon from the first Spider-man movie which she reluctantly accepts. Leonard and Penny are hanging out together where Leonard has set up the apartment with things Penny likes including snacks, beer and watching a football game. He even paints his chest with "Go Sports". Leonard tries to get her to discuss their relationship seriously, but she has had a rough day and just wants to hang. They are interrupted by Raj, who decided to leave Sheldon and Amy alone on their date. Raj tells them how great their relationship is until he learns that she has never told Leonard that she loves him. After Raj tries to get Penny to admit it, he gets kicked out of the apartment. Wandering over to the comic book store, Raj and Stuart strike up a friendship and agree to go out to see a movie. Howard video chats with Bernadette who is mad at him for not telling his mother that they are moving out. He buckles under to his mother and then tells Bernadette that everything worked out, thus lying to both of the women in his life. He may decide to stay in space.

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As Howard is in the Soyuz space capsule awaiting the launch to the International Space Station, his new wife and their friends are at Leonard and Sheldon's apartment watching the launch on the NASA channel. Howard, still scared about dying most specifically now by a botched launch, reminisces about the lead up to what was his and Bernadette's wedding. Bernadette was the one who decided that they should get married before the launch in a small but special ceremony, with only their immediate family and closest friends in attendance. The ceremony was threatened by the fact that their first and at that time only option of a civil ceremony at city hall couldn't happen due to a backlog. But Raj came up with what they all believed was an even better second option on launch day if they could pull it off. The personal issues of each within the wedding party had the potential of overshadowing what should have been Howard and Bernadette's most important day. That important day may also be shattered if Soyuz itself shatters upon launch.

With only a few weeks until the launch, Howard's space mission is scrapped due to technical difficulties. Rather than be disappointed, Howard is relieved, since he had always been scared of dying in space, something that he doesn't mention to anyone. However, NASA decides they do want him to go after all, instead sending him on an earlier mission... one that is scheduled to launch two days before his and Bernadette's wedding. He is hoping that Bernadette or Bernadette's tough as nails father will demand that he not go. Meanwhile, Penny decides that she wants to speed things up with Leonard, which Leonard is more than happy to do. But Leonard accidentally speeds things up just a little too much. And Amy does some speeding up of her own regarding her and Sheldon's relationship, regardless of if Sheldon likes it or not.

It's two weeks before Howard and Bernadette's wedding. While the gals have a gift bag packing evening while talking about Bernadette's chosen married name and some other unmentionables mentioned by Amy, the guys are out for what Howard assumes will be a subdued stag party since he has promised Bernadette that there will be no strippers at the event. It does end up being subdued as most bachelor parties go, but some information that comes to light at the stag threatens the wedding as well as Bernadette's friendship with Penny. Penny and Howard do whatever they can to right whatever wrongs came to light.

Renowned scientist Stephen Hawking is coming to the university for an extended guest lecture series, and an excited Howard has been asked to maintain the equipment on his wheelchair for his entire stay. Since Howard knows that Sheldon is enamored with Hawking considering him the only person on the face of the planet that is his intellectual equal, Howard plans on introducing Sheldon to Hawking, that is until Sheldon, who is yet unaware of Hawking's visit or Howard's connection, makes yet another of his condescending remarks about Howard's intellect or lack thereof. So Howard changes his mind. After Sheldon's pleading, Howard compromises: he will show Hawking Sheldon's just written paper on the boson particle, and if Hawking wants to meet him after that, he will arrange it. But first, Sheldon has to do a few favors for him, which Howard knows he can make as painful and degrading as he wants since this meeting is Sheldon's dream. Regardless, the paper will prove whether Sheldon really is Hawking's intellectual equal.

To show her appreciation for all the free meals she's had at their apartment, Penny, using money from an acting residual check, gives Leonard and Sheldon each a gift: a vintage, mint, in-the-box, 1975 Mego Star Trek (1966) Transporter, with real transporter action - apiece. They both love their gift. It has additional special meaning for Leonard since it was given to him from Penny with love. And it has additional special meaning for Sheldon since his Leonard Nimoy Spock miniature action figure would fit in the toy. However, Penny is dismayed to learn that neither Leonard or Sheldon plan on opening their respective gift to play with it since doing so would diminish its value. Later, Sheldon, hearing the voice of his Spock miniature action figure in his dreams telling him to do so, decides to open his gift to play with it. The result makes him contemplate secretly switching his now useless toy with Leonard's mint condition, still-in-the-box toy. Meanwhile, on the question of whether he will bring a date to Howard and Bernadette's wedding, a girlfriendless Raj makes a drastic decision: he will allow his parents to arrange a marriage for him. Although he really likes Lakshmi, his parent's choice of a wife for him, after their initial first few dates and thinks she may indeed be the one, an admission on her part makes Raj have to decide if marriage at any cost is worth it.

Raj comes up with the idea of going down memory lane by the guys having a weekend long gaming marathon like they used to do, this time playing the new game, Star Wars: The Old Republic (2011). Despite Howard, Leonard and Sheldon being in relationships, they all agree. However, the three respective females in their lives may have some say about what happens on the weekend. Leonard hopes that Penny will care and have something to say about not spending the weekend with him, which means that their relationship is progressing back into true boyfriend/girlfriend status. Howard may not be able to choose between spending the weekend gaming or spending it with Bernadette. But Sheldon, who previously agreed to go to Amy's aunt's 93rd birthday celebration, has quite an easy decision between spending the weekend with the guys or with Amy and her aunt: he chooses the guys. A hurt Amy has to decide what to do in light of Sheldon's obvious disregard for her feelings. But someone other than Amy may be even more hurt by how the weekend progresses.

Sheldon's orderly world is thrown into a tailspin when his regular barber, Mr. D'Onofrio, is in the hospital with a coma when Sheldon's regularly scheduled appointment arrives. He won't let anyone else in the area cut his hair since he believes Mr. D'Onofrio is the only one who can since he has all Sheldon's haircut records from Texas (or so Sheldon's mother told him). Even after his regularly scheduled haircut appointment is one day overdue, Sheldon can't stand it as he can hear his hair growing out of control. If Sheldon can't get Mr. D'Onofrio out of his coma, he will either have to let someone else cut his hair, or live with longer than usual hair. But what's worse, Sheldon believes that total anarchy will ensue since world order is based on his own personal order. The result of not getting is haircut makes Sheldon reevaluate his life plan. Meanwhile, Howard is scheduled to begin his astronaut training. Howard finds that the anticipation of the excitement of the training is nowhere close to the reality of training itself.