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Petri Dish
Petri Dish episodes
- Ep. 109 Artificial Sweeteners Pt 3: Rumors and Suspicions
This week on Petri Dish, Sean, Nathan, and special guest Andrei wrap up their discussion on non-nutritive sweeteners by looking at what evidence is out there on potential harmful impacts of these sweeteners. Do sweeteners cause cancer? Do they help you lose weight, or actually make you gain weight!? What about your microbiome, or the environment? Find out this week!
References:
- https://www.sciencedirect.com/science/article/pii/S0923753419510377
- https://www.jstor.org/stable/3702364
- https://link.springer.com/chapter/10.1007/978-3-030-53370-0_38
- https://link.springer.com/content/pdf/10.1007/s11894-017-0602-9.pdf
- https://www.tandfonline.com/doi/full/10.3109/17477160903497027
- https://www.sciencedirect.com/science/article/pii/S0195666320300192
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348013/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634742/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014832/
- https://www.tandfonline.com/doi/full/10.1080/17446651.2020.1740588
- https://cdnsciencepub.com/doi/full/10.1139/apnm-2019-0359
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363527/
- https://pubmed.ncbi.nlm.nih.gov/33171964/
- https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-020-00976-w
- https://www.mdpi.com/1422-0067/22/10/5228/htm
- https://www.nature.com/articles/nature13793?tdc_uid=921043
- https://www.sciencedirect.com/science/article/pii/S2666821121000168
- https://www.sciencedirect.com/science/article/pii/S0147651318313368
- https://setac.onlinelibrary.wiley.com/doi/10.1002/ieam.4248
53 min - Ep. 108 Artificial Sweeteners Pt 2: 'Natural'
Hey everyone! This week's episode continues our discussion on non-nutritive sweeteners! Last week we discussed synthetic sweeteners, the ones made in labs like Sweet N Low or Splenda. But there are sweeteners on the market that are 'natural', like stevia or monkfruit. What is up with those sweeteners? Are they just different kinds of sugars, or are they something else entirely?
References:
- https://www.mdpi.com/2072-6643/9/7/756
- https://www.theatlantic.com/health/archive/2014/01/whats-in-those-haribo-gummy-bears/283162/
- https://link.springer.com/article/10.1007/s13197-011-0571-1
- https://www.mdpi.com/2072-6643/12/2/322
- https://www.nature.com/articles/ncomms14733
- https://en.wikipedia.org/wiki/Monellin
- https://www.sciencedirect.com/science/article/abs/pii/S0003986100917259
35 min - Ep. 107 Artificial Sweeteners Pt 1: Finger Lickin' Sweet
This first episode in our three-parter on non-nutritive sweeteners is about the artificial stuff, the most-accidental discoveries that led to saccharin, aspartame, sucralose, all the big ones, all the hits! How do these synthetic sweeteners work? How do they differ from one another?
Next week we'll cover 'natural' non-nutritive sweeteners and the week after that we'll cover whether there are any risks to their frequent use!
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References:
- https://www.acs.org/content/acs/en/molecule-of-the-week/archive/s/saccharin.html
- https://www.saveur.com/artificial-sweeteners/
- https://www.mentalfloss.com/article/83730/sweet-and-not-so-sweet-history-saccharin
- https://www.nature.com/articles/243347a0
- https://pubmed.ncbi.nlm.nih.gov/15537898/
- https://www.sciencedirect.com/science/article/pii/S0304394018302908
- https://www.sciencedirect.com/science/article/pii/S2451945617302787
- https://www.sciencedirect.com/science/article/pii/S0271531719300491
- https://www.taylorfrancis.com/chapters/edit/10.1201/9781003065289-2/discovery-aspartame-robert-mazur
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856475/
50 min - Ep. 106 Alzheimer's Disease Pt. 3: Alternate Hypotheses
In this final episode of our series on Alzheimer's Disease, we discuss some of the alternate hypotheses for what actually causes and drives progression of Alzheimer's Disease, if not amyloid beta. What other ideas are some scientists working through?
Featuring a promo for Infectious Groove, a great podcast music podcast!
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References:
- https://pubmed.ncbi.nlm.nih.gov/29663818/
- https://www.frontiersin.org/articles/10.3389/fnins.2018.00025/full
- https://www.alzforum.org/research-models/alzheimers-disease
- https://www.frontiersin.org/articles/10.3389/fnagi.2019.00233/full
- https://pubmed.ncbi.nlm.nih.gov/15197750/
- https://www.ahajournals.org/doi/full/10.1161/ATVBAHA.120.311911
- https://content.iospress.com/articles/journal-of-alzheimers-disease/jad180004
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873778/
41 min - Ep. 105 Alzheimer's Disease Pt 2: FDA Approval
I don't know if y'all have heard or not, but a month ago the FDA approved a drug for the treatment of Alzheimer's Disease, the first one in a couple of decades. This approval was met with the resignation of some members of the FDA's own scientific advisory group, which had recommended that the drug not be approved. What is going on here? Let's get into the science behind this drug, how the approval process works, and what this whole situation means!
Featuring a promo for Just the Zoo of Us, a great podcast about animal facts!
Ad Link: https://omio.sjv.io/c/2544961/1078765/7385
References:
- https://www.fda.gov/drugs/news-events-human-drugs/fdas-decision-approve-new-treatment-alzheimers-disease
- https://www.reuters.com/business/healthcare-pharmaceuticals/us-fda-updates-label-biogens-alzheimers-drug-specify-disease-stage-2021-07-08/
- https://journals.lww.com/neurotodayonline/Fulltext/2021/07080/Dementia_Experts_on_Why_the_FDA_Approval_of.3.aspx
- https://www.accessdata.fda.gov/drugsatfda_docs/nda/2021/761178Orig1s000ClinPharm_Redacted.pdf
- https://mind.uci.edu/apoe4-carriers-show-early-breakdown-to-blood-brain-barrier-before-cognitive-impairment/
- https://www.accessdata.fda.gov/drugsatfda_docs/nda/2021/761178Orig1s000MedR_Redacted.pdf
54 min - Ep. 104 Alzheimer's Disease Pt 1: Amyloid Hypothesis
One of the top killers of people over the age of 65, Alzheimer's Disease is the target of cutting edge pharmaceutical research and basic science. What do we already know about the symptoms and their biological causes? As it turns out, there is still a good amount of controversy when it comes to the fundamental mechanism of this disease!
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References:
https://www.nia.nih.gov/health/alzheimers-disease-fact-sheet
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181715/
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(18)30403-4/fulltext
https://www.cdc.gov/aging/aginginfo/alzheimers.htm
https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms-causes/syc-20350447
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174086/
https://www.nature.com/articles/s41598-019-44848-2
https://link.springer.com/chapter/10.1007/978-3-319-72938-1_3
https://www.hopkinsmedicine.org/health/conditions-and-diseases/alzheimers-disease/earlyonset-alzheimer-disease
https://www.jneurosci.org/content/34/38/12893
https://www.nature.com/articles/s41598-018-37476-9
https://link.springer.com/article/10.1007/s00109-016-1427-y
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042623/
https://www.frontiersin.org/articles/10.3389/fnins.2018.00025/full?mod=article_inline
44 min - Ep. 103 Cloning Pt 2: Why Would Anyone Do This?
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Last week we discussed how someone could go about cloning something, but this week we dive into the WHY. Maybe there is no particularly good reason to do reproductive cloning for humans, but what about individuals of endangered species? What about trying to bring back recently extinct species? What about cloning to try to create new species?
Featuring a promo for The Bald Scientist Podcast!
References:
- https://www.ncbi.nlm.nih.gov/books/NBK223960/
- https://www.nature.com/articles/35016604
- https://www.nature.com/articles/cr201411
- https://www.proquest.com/docview/2300608608
- https://www.liebertpub.com/doi/full/10.1089/scd.2018.0162
- https://link.springer.com/protocol/10.1007/978-1-4939-9524-0_15
- https://link.springer.com/article/10.1007/s10539-016-9534-2
- https://www.mdpi.com/2073-4425/9/11/548/htm
- https://besjournals.onlinelibrary.wiley.com/doi/full/10.1111/1365-2435.12705
- https://www.yellowstonepark.com/things-to-do/wildlife/wolf-reintroduction-changes-ecosystem/
- https://reviverestore.org/projects/woolly-mammoth/progress-to-date/
45 min - Ep. 102: How to Make a Clone Pt 1
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Jurassic Park! Dolly the Sheep! Mammoths! Cloning went from science fiction to science, but maybe had fallen a bit out of vogue for a while? But some other concepts that can include cloning technology, like certain kinds of stem cell work and maybe bringing extinct species back to life! This episode, find out how reproductive cloning works! Next episode we'll talk about what it can be used for (and a little bit on whether we think it should be done at all).
Feat. a promo for For Your Reference, a TV/Movie discussion podcast!
References
- https://www.ncbi.nlm.nih.gov/books/NBK223960/
- https://www.genome.gov/about-genomics/fact-sheets/Cloning-Fact-Sheet
- https://www.mdpi.com/1422-0067/21/7/2314/htm
- http://www.ijdb.ehu.es/web/paper/180324mc/somatic-cell-nuclear-transfer-failures-successes-and-the-challenges-ahead
- https://onlinelibrary.wiley.com/doi/full/10.1111/rda.13138
- https://jasbsci.biomedcentral.com/articles/10.1186/s40104-015-0043-y
- https://www.nature.com/articles/385810a0.pdf
- https://dolly.roslin.ed.ac.uk/facts/the-life-of-dolly/index.html
- https://www.sciencedirect.com/science/article/pii/S0092867418300576
- https://science.sciencemag.org/content/344/6180/137.full
- https://www.mdpi.com/2076-3417/11/4/1850/htm
- https://www.frontiersin.org/articles/10.3389/fgene.2020.00205/full
- https://www.sciencedirect.com/science/article/pii/S1934590918303849
- https://www.pnas.org/content/115/47/E11071.short
36 min - Ep. 101 Allergies Pt. 4: Treatments and Future Cures
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Back from the brief interruption of our allergies series to celebrate our 100th episode, we're wrapping things up by talking about treatments for allergies and what scientists have been cooking up to help people get back to snorting cat dander. Don't worry, only one of the treatments involves getting purposefully infected with worms.
Feat. a promo for Oz-9, a very funny science fiction/comedy podcast!
References:
- https://onlinelibrary.wiley.com/doi/full/10.1111/all.13201
- https://www.sciencedirect.com/science/article/pii/S0952791520300212
- https://www.jci.org/articles/view/129697
- https://www.nature.com/articles/s41467-019-13815-w
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533538/
- https://www.frontiersin.org/articles/10.3389/fimmu.2019.00175/full
- https://onlinelibrary.wiley.com/doi/full/10.1111/all.14308
- https://www.frontiersin.org/articles/10.3389/fimmu.2019.00965/full
- https://immunology.sciencemag.org/content/5/43/eaav8402
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191488/
- https://www.sciencedirect.com/science/article/pii/S0753332219353077
- https://www.sciencedirect.com/science/article/pii/S1473309914707716
- https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1008508
- https://onlinelibrary.wiley.com/doi/full/10.1111/imm.13190
42 min - Ep. 100: The Big One Hundo
The 100th episode! Woo, we did it everyone! Thank you for listening to the podcast! This episode, Sean released his grip on the reins and let Nathan and Stacey pick topics to discuss, and so this episode is about:
The History of the Number Zero
Buttholes (Thanks, Nathan)
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Featuring a promo for Curiosity Kill the Rat, another great science podcast!
References:
- https://psycnet.apa.org/record/1996-10277-001
- https://www.vox.com/science-and-health/2018/7/5/17500782/zero-number-math-explained
- https://science.sciencemag.org/content/360/6393/1069
- https://pubs.rsc.org/en/content/articlehtml/2021/sm/d0sm01230k
52 min
About Petri Dish
From the publisher's feed
Profane, insane, and 100% primo science, Petri Dish is a no-BS podcast that explores the wildest subjects in modern science with clarity and evil joy.
Hosted by Sean Allen, a Nanoparticle/Immunology Researcher, and Nathan Allen, his "screenwriter" brother, Petri Dish fuses hard science with a freewheeling and madcap conversational style.
Cannabinoids, Plague, Cats, the dreaded Candiru, and the even more dreaded Covid-19: all these and more are dissected with intellect and irreverence, dropping every week.
So reject ignorance. Join the Scientific Revolution. Join Petri Dish.