Pharm5

Pharm5

By Elizabeth B. Hearn, PharmD, BCACPMedicineHealth & Fitness
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Pharm5 episodes

  • Two new FDA approved drugs, AGA obesity treatment guidelines, and more!

    This week on Pharm5:

    • Imjudo (tremelimumab) FDA approved
    • Tecvayli (teclistamab-cqyv) FDA approved
    • Cancer incidence up, mortality down
    • Pharmacies administered >50% of COVID vaccines
    • AGA Obesity Treatment Guidelines


      • Connect with us!

      • Listen to our podcast: Pharm5
      • Follow us on Twitter: @LizHearnPharmD


        • References:

        1. Imjudo (tremelimumab) in combination with Imfinzi approved in the US for patients with unresectable liver cancer. AstraZeneca. https://bit.ly/3NevJKX. Published October 24, 2022. Accessed October 27, 2022.
        2. Abou-Alfa GK, Lau G, Kudo M, et al. Tremelimumab Plus durvalumab in unresectable hepatocellular carcinoma. NEJM Evidence. 2022;1(8). doi:10.1056/evidoa2100070
        3. Center for Drug Evaluation and Research. FDA approves teclistamab-cqyv for relapsed or refractory multiple myeloma. U.S. Food and Drug Administration. https://bit.ly/3zqMixF. Accessed October 27, 2022.
        4. Cronin KA, Scott S, Firth AU, et al. Annual report to the nation on the status of cancer, part 1: National cancer statistics. Cancer. October 2022. doi:10.1002/cncr.34479
        5. Hunter E. Overall cancer death rates have declined, but rates among racial/ethnic minorities have not followed suit. Pharmacy Times. https://bit.ly/3gPg4G0.  Published October 27, 2022. Accessed October 27, 2022.
        6. Grabenstein JD. Essential services: Quantifying the contributions of America’s pharmacists in COVID-19 clinical interventions. Journal of the American Pharmacists Association. 2022. doi:10.1016/j.japh.2022.08.010
        7. @JAPhAJournal. IN PRESS: Pharmacists delivered over 350 million clinical interventions during COVID pandemic. #TwitteRx #pharmacists #COVID19. Posted October 25, 2022. Accessed October 27, 2022. https://bit.ly/3U1xn4N.
        8. Grunvald E, Shah R, Hernaez R, et al. AGA clinical practice guideline on pharmacological interventions for adults with obesity. Gastroenterology. 2022;163(5):1198-1225. doi:10.1053/j.gastro.2022.08.045
          9. 5 min
        9. Eliquis v. Xarelto, Adderall shortage, loan forgiveness, and more!

          This week on Pharm5:

          • Eliquis v. Xarelto for AFib
          • Improve M&M by quickly titrating HFrEF treatments
          • National Adderall shortage
          • Novavax ok’d as booster
          • Student loan forgiveness application


            • Connect with us!

            • Listen to our podcast: Pharm5
            • Follow us on Twitter: @LizHearnPharmD


              • References:

              1. Dawwas GK, Cuker A, Barnes GD, Lewis JD, Hennessy S. Apixaban versus rivaroxaban in patients with atrial fibrillation and valvular heart disease. Annals of Internal Medicine. October 2022. doi:10.7326/m22-0318
              2. Strong-HF study in patients admitted for acute heart failure (HF) terminated early for superior efficacy. STRONG-HF study in patients admitted for acute heart failure (HF) terminated early for superior efficacy. https://prn.to/3sbDrMv. Published October 13, 2022. Accessed October 14, 2022.
              3. Safety, tolerability, and efficacy of rapid optimization, helped by NT-probnp testing, of heart failure therapies - full text view. Safety, Tolerability and Efficacy of Rapid Optimization, Helped by NT-proBNP testinG, of Heart Failure Therapies - Full Text View - ClinicalTrials.gov. https://bit.ly/3MQktVd. Accessed October 14, 2022.
              4. Brooks M. FDA confirms nationwide Adderall shortage. Medscape. https://wb.md/3DfXS0O. Published October 14, 2022. Accessed October 14, 2022.
                5. FDA drug shortages. FDA. https://bit.ly/3yZiAzG. Accessed October 14, 2022.
              5. CDC allows Novavax monovalent COVID-19 boosters for adults ages 18 and older. Centers for Disease Control and Prevention. https://bit.ly/3VM10J9. Published October 19, 2022. Accessed October 20, 2022.
              6. Center for Biologics Evaluation and Research. Novavax COVID-19 vaccine. U.S. Food and Drug Administration. https://bit.ly/3eMcbkC. Accessed October 20, 2022.
              7. Federal Student Aid. https://bit.ly/3ToNLwC. Accessed October 20, 2022.
              8. Duster C. How to qualify for Biden's new student loan forgiveness plan. CNN Politics. https://cnn.it/3ALjKjF. Published Wednesday August 24, 2022. Accessed August 24, 2022.
              9. Occupational Employment and Wages, May 2021 - Pharmacists. U.S. Bureau of Labor Statistics. https://bit.ly/3PObHXm.  Published March 31, 2022. Accessed August 24, 2022.
              10. Smoot C. What is the average pharmacy school debt in 2022? SuperMoney. https://bit.ly/3PHqZNK. Published April 26, 2022. Accessed August 24, 2022.
                11. 5 min
              11. Pharmacy technician day, ISMP guidance for codes, and more!

                This week on Pharm5:

                • Pharmacy Technician Day
                • Boostrix during pregnancy
                • AMA reviews PBMs
                • COVID boosters for kids
                • ISMP guidance for pharmacists in codes


                  • Connect with us!

                  • Listen to our podcast: Pharm5
                  • Follow us on Twitter: @LizHearnPharmD


                    • References:

                    1. Pharmacy technician day. ASHP. https://bit.ly/3exFuaj. Accessed October 13, 2022.
                    2. 29-2052 pharmacy technicians. U.S. Bureau of Labor Statistics. https://bit.ly/3VuX0wr. Published March 31, 2022. Accessed October 13, 2022.
                    3. Resume CV development. ASHP. https://bit.ly/3EGX2LY. Accessed October 13, 2022.
                    4. FDA approves vaccine for use during third trimester of pregnancy to prevent whooping cough in infants younger than two months of age. U.S. Food and Drug Administration. https://bit.ly/3CAlc82. Accessed October 13, 2022.
                    5. New AMA report calls for state regulation of drug price middlemen. Yahoo! Finance. https://yhoo.it/3rWe0hQ. Accessed October 13, 2022.
                    6. Guardado JR. AMA. Competition in Commercial PBM Markets and Vertical Integration of Health Insurers with PBMs. https://bit.ly/3MwDSdx. Accessed October 13, 2022.
                    7. Coronavirus (COVID-19) update: FDA authorizes Moderna and Pfizer-BioNTech bivalent COVID-19 vaccines for use as a booster dose in younger age groups. U.S. Food and Drug
                    8. Administration. https://bit.ly/3TiXjZA. Accessed October 13, 2022.
                    9. CDC Covid Data tracker. Centers for Disease Control and Prevention. https://covid.cdc.gov/covid-data-tracker/#demographicsovertime. Accessed October 13, 2022.
                    10. Survey results from pharmacists provide support to enhance the organizational response to codes. Institute For Safe Medication Practices. https://bit.ly/3gaqejW. Published October 6, 2022. Accessed October 13, 2022.
                      11. 5 min
                    11. New MPJE blueprint, PREP Act Expansion, ProAir HFA discontinued, and more!

                      This week on Pharm5:

                      • ProAir HFA discontinued
                      • New MPJE blueprint
                      • PREP Act Expansion
                      • Ebola outbreak in Uganda
                      • American Pharmacists Month


                        • Connect with us!

                        • Listen to our podcast: Pharm5
                        • Follow us on Twitter: @LizHearnPharmD


                          • References

                          1. ProAir HFA®. Albuterol Inhalers. https://bit.ly/3CfEpvB. Accessed October 6, 2022.
                          2. ProAir manufacturer discontinuation. NC Medicaid. https://bit.ly/3Vm54Qn. Accessed October 6, 2022.
                          3. Home Page: Department of Vermont health access. Home Page | Department of Vermont Health Access. https://bit.ly/3Mayn45. Accessed October 6, 2022.
                          4. Multistate Pharmacy Jurisprudence Examination (MPJE): NABP. National Association of Boards of Pharmacy. https://bit.ly/3RJpYWz. Published October 6, 2022. Accessed October 6, 2022.
                          5. HHS amends prep act declaration increasing workforce authorized to administer monkeypox vaccines. https://bit.ly/3MbuX0V. Accessed October 6, 2022.
                          6. JYNNEOS vaccine fact sheet - EZIZ. https://bit.ly/3V8zvJx. Accessed October 7, 2022.
                          7. Daniel R. Lucey MD. Uganda ebola outbreak grows to more than 60 cases, 882 contacts and a fourth district. IDSA Home. https://bit.ly/3RXIavL. Accessed October 6, 2022.
                          8. Ebola virus disease. World Health Organization. https://bit.ly/3T68x3d. Accessed October 6, 2022.
                          9. American Pharmacists Month. APhM. https://bit.ly/3CEncNK. Accessed October 6, 2022.
                          10. Pharmacy technician day. ASHP. https://bit.ly/3rCTN0f. Accessed October 6, 2022.
                            11. 4 min
                          11. Hurricane Ian, statin + ezetimibe, monkeypox updates, and more!

                            This week on Pharm5:

                            • LDL <70 on statin + ezetimibe reduces stroke risk
                            • Monkeypox indications expand, & just 1 dose is helpful
                            • On-X aortic valve needs warfarin
                            • Relyvrio FDA approved for ALS
                            • Emergency refills in Hurricane Ian


                              • Connect with us!

                              • Listen to our podcast: Pharm5
                              • Follow us on Twitter: @LizHearnPharmD


                                • References

                                1. Amarenco P, Kim JS, Labreuche J, et al. Yield of dual therapy with statin and Ezetimibe in the treat stroke to target trial. Stroke. September 2022. doi:10.1161/strokeaha.122.039728
                                2. Monkeypox Vaccination Basics. Centers for Disease Control and Prevention. https://bit.ly/3UOhwb0. Published September 28, 2022. Accessed September 29, 2022.
                                3. Monkeypox cases by age and gender, race/ethnicity, and symptoms. Centers for Disease Control and Prevention. https://bit.ly/3SpTphr. Published August 22, 2022. Accessed September 29, 2022.
                                4. Weiland N. C.D.C. says early data offers positive signs about monkeypox vaccine. The New York Times. https://nyti.ms/3SKc0o5. Published September 28, 2022. Accessed September 29, 2022.
                                5. Artivion I. Artivion follows recommendation to stop proact xa clinical trial. Artivion Follows Recommendation to Stop PROACT Xa Clinical Trial. https://prn.to/3BVSiip. Published September 23, 2022. Accessed September 29, 2022.
                                6. Kido K, Ball J. Optimal intensity of warfarin therapy in patients with mechanical aortic valves. Journal of Pharmacy Practice. 2017;32(1):93-98. doi:10.1177/0897190017734765
                                7. FDA approves new treatment option for patients with ALS. U.S. Food and Drug Administration. https://bit.ly/3e0eT5n. Accessed September 29, 2022.
                                8. ALS drug gets FDA panel thumbs up after Rare second look. Medscape. https://wb.md/3y3XAHn. Published September 29, 2022. Accessed September 29, 2022.
                                9. Governor DeSantis declares state of emergency for Hurricane Ian. Florida Board of Pharmacy. https://bit.ly/3E5XFyq. Accessed September 29, 2022.
                                10. South Carolina Board of Pharmacy. SCLLR. https://bit.ly/3LT1M2q. Accessed September 29, 2022.
                                  11. 4 min
                                11. Terlipressin for HRS, mRNA flu vaccine, and more!

                                  This week on Pharm5:

                                  • Terlivaz (terlipressin) for hepatorenal syndrome
                                  • Pfizer’s mRNA flu vaccine (enroll here: https://bit.ly/3DMRO0r)
                                  • Potential triple-action drug for diabetes or weight loss
                                  • Warfarin use in AFib with rheumatic heart disease
                                  • CVS and Walmart settle; Walgreens heads to court


                                    • References

                                    1. Terlivaz. Package Insert. Mallinckrodt Pharmaceuticals; 2022.
                                    2. Pharmacypracticenews.com. https://bit.ly/3xHxgTm. Published September 15, 2022. Accessed September 22, 2022.
                                    3. Biggins SW, Angeli P, Garcia‐Tsao G, et al. Diagnosis, evaluation, and management of ascites, spontaneous bacterial peritonitis and Hepatorenal Syndrome: 2021 practice guidance by the American Association for the study of liver diseases. Hepatology. 2021;74(2):1014-1048. doi:10.1002/hep.31884
                                    4. Pfizer initiates phase 3 study of mrna-based influenza vaccine. Pfizer. https://bit.ly/3dBgvCx. Published September 14, 2022. Accessed September 22, 2022.
                                    5. Mitchel L. Zoler PD. Triple threat: Novel agent shows potent T2D Weight Loss. Medscape. https://wb.md/3SmPWzK. Published September 22, 2022. Accessed September 22, 2022.
                                    6. A1C and weight change results: Mounjaro™ (tirzepatide). Mounjaro. https://bit.ly/3DNdutI. Accessed September 22, 2022.
                                    7. Connolly SJ, Karthikeyan G, Ntsekhe M, et al. Rivaroxaban in rheumatic heart disease–associated atrial fibrillation. New England Journal of Medicine. 2022;387(11):978-988. doi:10.1056/nejmoa2209051
                                    8. Knauth D. CVS, Walmart reach $147.5 million opioid settlement with West Virginia. Medscape. https://wb.md/3BGNWeK. Published September 22, 2022. Accessed September 22, 2022.
                                      9. 4 min
                                    9. OTC oral contraceptive, WHO fighting to end bacterial meningitis, and more!

                                      This week on Pharm5 with special guests Karl Meyer and Shana Morrison:

                                      • OTC oral contraceptive
                                      • Post-surgical VTE prophylaxis with apixaban
                                      • WHO fighting to end bacterial meningitis
                                      • FDA approvals: Sotyktu, Rolvedon
                                      • COVID vaccine decreases MIS-C risk


                                        • Connect with us!

                                        • Listen to our podcast: Pharm5
                                        • Watch us on TikTok: @LizHearnPharmD
                                        • Follow us on Twitter: @LizHearnPharmD


                                          • References

                                          1. Park B. FDA panel meeting scheduled to discuss RX-to-OTC switch of oral contraceptive opill. MPR. https://bit.ly/3BnOTZm. Published September 13, 2022. Accessed September 15, 2022.
                                          2. ASHP Policy week 2022. ASHP. https://bit.ly/3SbbeA2.  Accessed September 15, 2022.
                                          3. Pharmacist-prescribed contraceptives. Guttmacher Institute. https://bit.ly/3Bn44Cg.  Published August 24, 2022. Accessed September 15, 2022.
                                          4. Westerman ME, Bree KK, Msaouel P, et al. Apixaban vs enoxaparin for post-surgical extended-duration venous thromboembolic event prophylaxis: A prospective quality improvement study. Journal of Urology. 2022;208(4):886-895. doi:10.1097/ju.0000000000002788
                                          5. Henderson Rby E. Oral anticoagulant drug may be safe, effective in preventing blood clots after Urologic Cancer surgery. News. https://bit.ly/3BJFlcA. Published September 13, 2022. Accessed September 15, 2022.
                                          6. Mutsaka F. Who launches drive to fight bacterial meningitis in Africa. AP NEWS. https://bit.ly/3BJETLl. Published September 8, 2022. Accessed September 14, 2022.
                                          7. Uhl R, Riga T. Spectrum Pharmaceuticals receives FDA approval for Rolvedon™ (eflapegrastim-xnst) injection. Spectrum Pharmaceuticals, Inc. https://bit.ly/3BiRowg. Published September 9, 2022. Accessed September 14, 2022.
                                          8. Dykes L. Deucravacitinib receives FDA approval for moderate-to-severe plaque psoriasis. Rheumatology Network. https://bit.ly/3eRss7m. Published September 10, 2022. Accessed September 14, 2022.
                                          9. Zambrano LD, Newhams MM, Olson SM, et al. BNT162B2 mrna vaccination against COVID-19 is associated with a decreased likelihood of multisystem inflammatory syndrome in children aged 5–18 years—United States, July 2021 – April 2022. Clinical Infectious Diseases. 2022. doi:10.1093/cid/ciac637
                                            10. 4 min
                                          10. Dolutegravir for HIV1+ pregnant patients, NM v. Purdue Pharma, annual COVID-19 boosters, and more!

                                            This week on Pharm5:

                                            • NM vs. Purdue Pharma, et al.
                                            • Antibiotic timing in bloodstream infections
                                            • Spevigo for pustular psoriasis flares
                                            • Annual COVID-19 boosters
                                            • Dolutegravir for pregnant patients living with HIV1


                                              • Connect with us!

                                              • Listen to our podcast: Pharm5
                                              • Watch us on TikTok: @LizHearnPharmD
                                              • Follow us on Twitter: @LizHearnPharmD


                                                • References

                                                1. Siegel D. Three major pharmacy operators begin latest opioid trial in New Mexico, watch online via CVN. CVN News. https://bit.ly/3RtFcQ9. Published September 7, 2022. Accessed September 8, 2022.
                                                2. Pierson B. Pharmacy Operators Walmart, Walgreens, Kroger begin opioid trial in New Mexico. Reuters. https://reut.rs/3Rwi43e. Published September 6, 2022. Accessed September 8, 2022.
                                                3. Van Heuverswyn J, Valik JK, van der Werff SD, Hedberg P, Giske C, Nauclér P. Association between time to appropriate antimicrobial treatment and 30-day mortality in patients with bloodstream infections: A retrospective cohort study. Clinical Infectious Diseases. September 2022. doi:10.1093/cid/ciac727
                                                4. Boehringer. https://bit.ly/3x7N1mi. Published September 1, 2022. Accessed September 8, 2022.
                                                5. Spevigo. Package Insert. Boehringer Ingelheim Pharmaceuticals, Inc; 2022.
                                                6. Bendix A. Covid vaccines will likely become annual like flu shots, health officials say. NBCNews.com. https://nbcnews.to/3cWpcXU. Published September 6, 2022. Accessed September 8, 2022.
                                                7. Statement by President Biden on FDA and CDC authorizing updated COVID-19 vaccines. The White House. https://bit.ly/3KYpABy. Published September 6, 2022. Accessed September 8, 2022.
                                                8. Patel K, Huo Y, Jao J, et al. Dolutegravir in pregnancy as compared with current HIV regimens in the United States. New England Journal of Medicine. 2022;387(9):799-809. doi:10.1056/nejmoa2200600
                                                  9. 5 min
                                                9. Farxiga for HFpEF, Bivalent Boosters, Pharmacy in the Times, and more!

                                                  This week on Pharm5:

                                                  • Farxiga (dapagliflozin) for HFpEF
                                                  • Updated boosters for COVID-19
                                                  • Xenpozyme (olipudase alfa) for rare ASMD
                                                  • New York Times on “growing chains, falling wages”
                                                  • Phase III olokizumab vs. adalimumab for RA


                                                    • Connect with us!

                                                    • Listen to our podcast: Pharm5
                                                    • Watch us on TikTok: @LizHearnPharmD
                                                    • Follow us on Twitter: @LizHearnPharmD


                                                      • References

                                                      1. Solomon SD, McMurray JJV, Claggett B, et al. Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction. New England Journal of Medicine. August 2022. doi:10.1056/nejmoa2206286
                                                      2. FDA Approves Treatment for Wider Range of Patients with Heart Failure https://bit.ly/3B20I8N.  Published February 24, 2022. Accessed February 24, 2022.
                                                      3. Coronavirus (COVID-19) update: FDA authorizes Moderna, Pfizer-BioNTech bivalent COVID-19 vaccines for use as a booster dose. U.S. Food and Drug Administration. https://bit.ly/3cDuyHd. Accessed August 31, 2022.
                                                      4. Scheiber N. How pharmacy work stopped being so great. The New York Times. https://www.nytimes.com/2022/08/20/business/economy/pharmacists-job-inflation.html. Published August 20, 2022. Accessed September 1, 2022.
                                                      5. FDA approves first treatment for acid sphingomyelinase deficiency, a rare genetic disease. U.S. Food and Drug Administration. https://bit.ly/3AziPS5. Accessed August 31, 2022.
                                                      6. Dunleavy K. Sanofi's rare disease drug XENPOZYME scores FDA approval after nods in Japan and Europe. Fierce Pharma. https://bit.ly/3B3kz7F. Published August 31, 2022. Accessed August 31, 2022.
                                                      7. Smolen JS, Feist E, Fatenejad S, et al. Olokizumab versus placebo or adalimumab in rheumatoid arthritis. New England Journal of Medicine. 2022;387(8):715-726. doi:10.1056/nejmoa2201302
                                                        8. 5 min
                                                      8. Student loan relief, dextromethorphan for depression, and more!

                                                        This week on Pharm5:

                                                        • Rapid-acting Auvelity (bupropion/dextromethorphan) for MDD
                                                        • USPSTF’s updated statin recommendations
                                                        • Post flu vaccination hyperglycemia in type 2 diabetes
                                                        • Twice annual HIV treatment lenacapavir approved in Europe; awaiting FDA approval
                                                        • Student loan forgiveness


                                                          • Connect with us!

                                                          • Listen to our podcast: Pharm5
                                                          • Watch us on TikTok: @LizHearnPharmD
                                                          • Follow us on Twitter: @LizHearnPharmD


                                                            • References:

                                                            1. Saro Arakelians PD. Daily medication pearl: Dextromethorphan and bupropion (Auvelity). Pharmacy Times. https://bit.ly/3QPIRY8. Published August 24, 2022. Accessed August 24, 2022.
                                                            2. Auvelity (dextromethorphan and bupropion). Package insert. Axsome Therapeutics, Inc; 2022.
                                                            3. @DrWestling15. “FDA just approved Auvelity (Dextromethorphan-Bupropion) for Major Depressive Disorder! What should a pharmacist know about this?” https://bit.ly/3R4WKkX. Published August 22, 2022. Accessed August 24, 2022.
                                                            4. Mangione CM, Barry MJ, Nicholson WK, et al. Statin use for the primary prevention of cardiovascular disease in adults. JAMA. 2022;328(8):746. doi:10.1001/jama.2022.13044.
                                                            5. Arnett DK, Blumenthal RS, Albert MA, et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;140(11). doi:10.1161/cir.0000000000000678
                                                            6. Blood sugars higher for flu vaccine recipients with diabetes. U.S. Pharmacist – The Leading Journal in Pharmacy. https://bit.ly/3PKbDrH. Published August 24, 2022. Accessed August 24, 2022.
                                                            7. Hulsizer AL, Witte AP, Attridge RL, Urteaga EM. Hyperglycemia Post-Influenza vaccine in patients with diabetes. Annals of Pharmacotherapy. June 2022:106002802210981. doi:10.1177/10600280221098101
                                                            8. Kansteiner F. Gilead HIV prospect escapes FDA hold after glass compatibility glitch triggered regulatory setbacks. Fierce Pharma. https://bit.ly/3R3h3yY. Published May 17, 2022. Accessed August 24, 2022.
                                                            9. Gilead announces first global regulatory approval of Sunlenca® (Lenacapavir), the only twice-yearly HIV treatment option. Gilead Announces First Global Regulatory Approval of Sunlenca® (Lenacapavir), the Only Twice-Yearly HIV Treatment Option. https://bit.ly/3dXZd2t. Accessed August 24, 2022.
                                                            10. Duster C. How to qualify for Biden's new student loan forgiveness plan. CNN Politics. https://cnn.it/3ALjKjF. Published Wednesday August 24, 2022. Accessed August 24, 2022.
                                                            11. Occupational Employment and Wages, May 2021 - Pharmacists. U.S. Bureau of Labor Statistics. https://bit.ly/3PObHXm.  Published March 31, 2022. Accessed August 24, 2022.
                                                            12. Smoot C. What is the average pharmacy school debt in 2022? SuperMoney. https://bit.ly/3PHqZNK. Published April 26, 2022. Accessed August 24, 2022.
                                                              13. 5 min

                                                            About Pharm5

                                                            From the publisher's feed

                                                            The top five things happening in pharmacy this week in five minutes or less! Hosted by assistant professor of pharmacotherapy and board certified ambulatory care pharmacist, Dr. Elizabeth B. Hearn.