Pharm5

Pharm5

By Elizabeth B. Hearn, PharmD, BCACPMedicineHealth & Fitness
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Pharm5 episodes

  • SPECIAL RELEASE: Updated CHEST Guidelines for Perioperative Management of Antithrombotic Therapy

    This week on Pharm5:

    • What most pharmacists need to know about the newest CHEST Guidelines for Perioperative Management of Antithrombotic Therapy!


      • Connect with us!

      • Listen to our podcast: Pharm5
      • Watch us on TikTok: @LizHearnPharmD
      • Follow us on Twitter: @LizHearnPharmD


        • References:

        1. Douketis JD, Spyropoulos AC, Murad MH, et al. Perioperative management of antithrombotic therapy: An american college of chest physicians clinical practice guideline. Chest. August 2022. doi:10.1016/j.chest.2022.07.025
        2. Douketis JD, Spyropoulos AC, Spencer FA, et al. Perioperative management of antithrombotic therapy. Chest. 2012;141(2). doi:10.1378/chest.11-2298
          3. 6 min
        3. Inflation Reduction Act, Intradermal Jynneos, and more!

          This week on Pharm5:

          • Inflation Reduction Act’s impact on Medicare Part D
          • Monkeypox and Jynneos vaccine updates
          • Tennessee sues Walgreens for opioid over-distribution
          • FDA declines Nuplazid’s indication for Alzheimer’s psychosis
          • Two BP readings better predicts ASCVD risk


            • References:

            1. Statement by president Biden on Senate Passage of the inflation reduction act. The White House. https://bit.ly/3dcWRfs. Published August 7, 2022. Accessed August 11, 2022.
            2. Part D Senior Savings Model (insulin savings) common questions & answers. https://go.cms.gov/3SGrKcx.  Accessed August 11, 2022.
            3. JYNNEOS vaccine. Centers for Disease Control and Prevention. https://bit.ly/3STVq6e. Published August 10, 2022. Accessed August 11, 2022.
            4. FDA authorizes intradermal use of Jynneos vaccine for Monkeypox. Medscape. https://wb.md/3C2K9ua.  Published August 9, 2022. Accessed August 11, 2022.
            5. Assistant Secretary for Public Affairs (ASPA). Biden-Harris Administration Bolsters Monkeypox Response; HHS secretary Becerra declares public health emergency. HHS.gov. https://bit.ly/3pabFhK. Published August 5, 2022. Accessed August 11, 2022.
            6. Williams J. Judge says Walgreens contributed to San Francisco's opioid crisis. PBS. https://to.pbs.org/3zMFH04. Published August 10, 2022. Accessed August 11, 2022.
            7. Gorman S. Tennessee sues Walgreens Pharmacy chain over Opioid Distribution. Medscape. https://wb.md/3Qk2VkW. Published August 5, 2022. Accessed August 11, 2022.
            8. Staff R. FDA declines to approve expanded use of antipsychotic drug. Medscape. https://wb.md/3bIlSz2. Published August 5, 2022. Accessed August 11, 2022.
            9. Clark CE, Warren FC, Boddy K, et al. Higher arm versus lower arm systolic blood pressure and cardiovascular outcomes: A meta-analysis of individual participant data from the Interpress-IPD Collaboration. Hypertension. August 2022. doi:10.1161/hypertensionaha.121.18921.
            10. Whelton P, Carey R, Aronow W, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. J Am Coll Cardiol. 2018 May, 71 (19) e127–e248. https://doi.org/10.1016/j.jacc.2017.11.006.
              11. 5 min
            11. OTC options for pets, monkeypox updates, historically low uninsured rates, and more!

              This week on Pharm5:

              • Pfizer’s Phase 2 trials for revamped COVID vaccine
              • Monkeypox updates: vaccines and treatment options
              • Treating animal infections with OTC topical medications
              • Uninsured rates hit historic US low
              • ASHP’s guidance to prevent controlled substance diversion


                • References:

                1. Pfizer and BioNTech advance COVID-19 vaccine strategy with study start of next-generation vaccine candidate based on enhanced spike protein design. Pfizer. https://bit.ly/3OVxagF.  Published July 27, 2022. Accessed August 4, 2022.
                2. FDA Briefing Document Vaccines and Related Biological Products Advisory Committee Meeting. https://bit.ly/3I1wZhY. Published June 28, 2022. Accessed June 30, 2022.
                3. JYNNEOS monkeypox vaccine distribution by jurisdiction. https://bit.ly/3vBs0zt. Accessed August 4, 2022.
                4. FDA provides update on agency response to Monkeypox Outbreak. U.S. Food and Drug Administration. https://bit.ly/3bw93rj. Published July 29, 2022. Accessed August 4, 2022.
                5. Lundberg A, Koch SN, Bierbrier L, Slater M. Treating common skin conditions of cats and dogs in a community setting. Today's Veterinary Practice. 2022:100-106. Accessed August 4, 2022.
                6. Spitnagel MB, Hillier A, Gober M, Carlson MD. Treatment complexity and caregiver burden are linked in owners of dogs with allergic/atopic dermatitis. Vet Dematol. 2021;32(2):192-e50. Accessed August 4, 2022.
                7. Assistant Secretary for Public Affairs (ASPA). New HHS report shows national uninsured rate reached all-time low in 2022. HHS.gov. https://bit.ly/3zwU48y Published August 2, 2022. Accessed August 4, 2022.
                8. Number of retail prescription drugs filled at pharmacies by payer. KFF. https://bit.ly/3QmntJ8 Published March 5, 2020. Accessed August 4, 2022.
                9. ASHP releases revised guidelines on preventing diversion of controlled substances. ASHP. https://bit.ly/3d5XZ4F. Published August 2, 2022. Accessed August 4, 2022.
                  10. 5 min
                10. COVID vaccines linked to fewer CV events, Paxlovid reimbursements, and more!

                  This week on Pharm5:

                  • Polio in the US
                  • COVID vaccines linked to fewer CV events
                  • Vancomycin AUC vs. target troughs
                  • CMS Star Ratings 2022
                  • Payment model is needed for Paxlovid prescribing


                    • Use APhA’s pre-written, editable letter to advocate for pharmacist reimbursement for Paxlovid prescribing: https://bit.ly/3cKwm0O


                    References:

                    1. Meko H. First polio case in nearly a decade is detected in New York State. The New York Times. https://nyti.ms/3JbGLid. Published July 21, 2022. Accessed July 28, 2022.
                    2. Polio vaccine effectiveness and duration of protection. Centers for Disease Control and Prevention. https://bit.ly/3JhiIyy. Published May 4, 2018. Accessed July 28, 2022.
                    3. Kim Y-E, Huh K, Park Y-J, Peck KR, Jung J. Association between vaccination and acute myocardial infarction and ischemic stroke after COVID-19 infection. JAMA. July 2022. doi:10.1001/jama.2022.12992
                    4. Abdelmessih E, Patel N, Vekaria J, et al. Vancomycin area under the curve versus trough only guided dosing and the risk of acute kidney injury: Systematic Review and meta‐analysis. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. July 2022. doi:10.1002/phar.2722
                    5. Chung D, Efta J, Brunsman A, et al. Evaluation of pharmacist time dedicated to vancomycin dosing in adult patients using a 24-hour AUC nomogram or Trough Monitoring Approach: A time motion study. American Journal of Health-System Pharmacy. 2022;79(14):1173-1179. doi:10.1093/ajhp/zxac094
                    6. Press release CMS releases 2022 Medicare Advantage and Part D star ratings to help Medicare beneficiaries compare plans. CMS. https://go.cms.gov/3oEzpKM. Accessed July 28, 2022.
                    7. Emergency action is necessary to provide payment for pharmacist prescribing of Paxlovid. OneClickPolitics. https://bit.ly/3cKwm0O. Accessed July 28, 2022.
                      8. 5 min
                    8. Pharmacy's Response to HHS Guidance for Retail Pharmacies and more!

                      This week on Pharm5:

                      • Concerns with HHS guidance to retail pharmacies
                      • Drug overdose disparities
                      • Antimicrobial resistance after COVID-19
                      • Colloid v. crystalloid during cardiac surgery
                      • Novavax endorsed by CDC


                        • References:

                        1. Christensen J. Biden administration says pharmacies can't turn away people who have a prescription for a drug that may end a pregnancy. CNN. https://cnn.it/3olj1id. Published July 13, 2022. Accessed July 14, 2022.
                        2. ASHP response and advocacy related to recent federal guidance to "retail pharmacies" on access to Reproductive Health. ASHP. https://bit.ly/3RQHusT. Accessed July 21, 2022.
                        3. Drug overdose deaths rise, Disparities Widen. Centers for Disease Control and Prevention. https://bit.ly/3PNKSTP. Accessed July 21, 2022.
                        4. U.S. must curb rising rate of resistance to antimicrobials. IDSA Home. https://bit.ly/3PKz5FS.  Accessed July 21, 2022.
                        5. Covid-19: U.S. impact on Antimicrobial Resistance, Special Report 2022. June 2022. doi:10.15620/cdc:117915
                        6. Pesonen E, Vlasov H, Suojaranta R, et al. Effect of 4% albumin solution vs Ringer acetate on major adverse events in patients undergoing cardiac surgery with cardiopulmonary bypass. JAMA. 2022;328(3):251. doi:10.1001/jama.2022.10461
                        7. CDC recommends Novavax's COVID-19 vaccine for adults. Centers for Disease Control and Prevention. https://bit.ly/3zm4Tv4. Published July 19, 2022. Accessed July 21, 2022.
                          8. 5 min
                        8. Updates on Roe V. Wade, Novavax, monkeypox, and more!

                          This week on Pharm5:

                          • Pharmacists not required to turn away teratogenic prescriptions
                          • New, protein-based COVID-19 vaccine receives EUA
                          • Monkeypox update
                          • Delaware HB399 for Pharmacists Test and Treat
                          • BPS scores released


                            • References:

                            1. Christensen J. Biden administration says pharmacies can't turn away people who have a prescription for a drug that may end a pregnancy. CNN. https://cnn.it/3olj1id. Published July 13, 2022. Accessed July 14, 2022.
                            2. Coronavirus (COVID-19) update: FDA authorizes emergency use of Novavax COVID-19 vaccine, adjuvanted. U.S. Food and Drug Administration. https://bit.ly/3B5SNb5. Accessed July 14, 2022.
                            3. 2022 U.S. Map & Case count. Centers for Disease Control and Prevention. https://bit.ly/3aG6h2i.  Published July 13, 2022. Accessed July 14, 2022.
                            4. Fact sheet: Biden-Harris Administration's Monkeypox Outbreak response. The White House. https://bit.ly/3o2hYTX.  Published June 29, 2022. Accessed July 14, 2022.
                            5. Dem, D. House passes pharmacist test to treat bill. Blue Delaware. https://bit.ly/3uNocLr. Published June 17, 2022. Accessed July 14, 2022.
                            6. Pharmacist prescribing: "test and treat". NASPA. https://bit.ly/3Rw9e6b. Published July 11, 2022. Accessed July 14, 2022.
                            7. Board of Pharmacy Specialties (BPS) homepage. Board of Pharmacy Specialties. https://bit.ly/3z4QOC6. Accessed July 14, 2022.
                              8. 4 min
                            8. Pharmacists prescribing Paxlovid, flu shot updates for elderly, and more!

                              This week on Pharm5:

                              • Pharmacists prescribing Paxlovid
                              • New oncology payment model from CMS
                              • Flu shot updates for ≥65 years old
                              • Conflicting mortality and morbidity data for LVADs in heart failure
                              • Cardiometabolic trends in the 2000s


                                • References:

                                1. Coronavirus (COVID-19) update: FDA authorizes pharmacists to prescribe paxlovid with certain limitations. U.S. Food and Drug Administration. https://bit.ly/3AuDqbB. Published July 6, 2022. Accessed July 7, 2022.
                                2. Enhancing oncology model: CMS innovation center. Innovation Center. https://bit.ly/3yq4bLD. Published June 27, 2022. Accessed July 7, 2022.
                                3. CDC director adopts preference for specific flu vaccines for seniors. Centers for Disease Control and Prevention. https://bit.ly/3ynmotw. Published June 30, 2022. Accessed July 7, 2022.
                                4. https://bit.ly/3yOSrUE
                                5. Vidula H, Takeda K, Estep JD, et al. Hospitalization patterns and impact of a magnetically-levitated left ventricular assist device in the momentum 3 trial. JACC. https://bit.ly/3yQVY4R. Published July 1, 2022. Accessed July 7, 2022.
                                6. Cogswell R, Rogers JG, M.R. M, et al. Residual heart failure on mechanically assisted circulation: A call to action. JACC. https://bit.ly/3yOSrUE. Published July 1, 2022. Accessed July 7, 2022.
                                7. O’Hearn M, Lauren BN, Wong JB, Kim DD, Mozaffarian D. Trends and disparities in cardiometabolic health among U.S. adults, 1999-2018. Journal of the American College of Cardiology. 2022;80(2):138-151. doi:10.1016/j.jacc.2022.04.046
                                  8. 5 min
                                8. Implications of Roe v. Wade, Fall 2022 COVID Booster, and more!

                                  This week on Pharm5:

                                  • Roe v. Wade overturned
                                  • ASHP’s response and conflicts of interest
                                  • Fall 2022 COVID-19 booster update
                                  • USPSTF vitamin recommendation statement
                                  • Qsymia for obesity in youth


                                    • References:

                                    1. Supreme Court of the United States. https://bit.ly/3u80DfV. Accessed June 30, 2022.
                                    2. MacNaughton H, Nothnagle M, Early J.
                                    3. Mifepristone and Misoprostol for early pregnancy loss and medication abortion. American Family Physician. https://bit.ly/3I2ASmQ. Published April 15, 2021. Accessed June 29, 2022. ASHP Calls for Patients’ Rights to Access Reproductive Health Services. ASHP. https://bit.ly/3NvI7oz. Accessed June 29, 2022.
                                    4. Legislators We Support. ASHP. https://bit.ly/3I9FN5x. Accessed June 29, 2022.
                                    5. Carter: Life wins! Congressman Buddy Carter. https://bit.ly/3y59mk7. Published June 24, 2022. Accessed June 29, 2022.
                                    6. @SC_PharmD Oh god I already hate it here https://twitter.com/SC_PharmD/status/1542121672546717696. Posted June 29, 2022.
                                    7. FDA Briefing Document Vaccines and Related Biological Products Advisory Committee Meeting. https://bit.ly/3I1wZhY. Accessed June 30, 2022.
                                    8. Lafraniere S, Weiland N. F.D.A. advisers recommend updated boosters targeting forms of Omicron. The New York Times. https://nyti.ms/3I3sljt. Published June 28, 2022. Accessed June 29, 2022.
                                    9. Mangione CM, Barry MJ, Nicholson WK, et al. Vitamin, mineral, and multivitamin supplementation to prevent cardiovascular disease and cancer. JAMA. 2022;327(23):2326. doi:10.1001/jama.2022.8970
                                    10. Childhood Obesity Facts. Centers for Disease Control and Prevention. https://bit.ly/3Ox33gf. Published May 17, 2022. Accessed June 30, 2022.
                                    11. FDA approves Qsymia for treating teens with obesity. Medscape. https://wb.md/3a5ywXY. Published June 28, 2022. Accessed June 30, 2022.
                                    12. Qsymia. Package Insert. Vivus, LLC; 2022.
                                      13. 4 min
                                    13. Medicare Part D vs. Mark Cuban, MSM can donate blood in the ADVANCE study, and more!

                                      This week on Pharm 5:

                                      • Medicare Part D overpaying by $3.6B vs. Mark Cuban
                                      • Vaxneuvance Pneumococcal-15 for kids
                                      • Healthcare Implications from Biden’s LGBTQI+ Executive Order
                                      • ANCHOR Study reduces progression to anal cancer by 57% in PLWH and HSIL
                                      • ADVANCE Study enrollment open for MSM interested in donating blood


                                        • References:

                                        1. Lalani HS, Kesselheim AS, Rome BN. Potential medicare part D savings on generic drugs from the Mark Cuban Cost Plus Drug Company. Annals of Internal Medicine. 2022. doi:10.7326/m22-0756
                                        2. Merck & Co., Inc. U.S. FDA Approves Merck’s VAXNEUVANCETM (Pneumococcal 15-valent Conjugate Vaccine) for the Prevention of Invasive Pneumococcal Disease in Infants and Children. Merck.com. https://bit.ly/3tXVlDL. Published June 22, 2022. Accessed June 23, 2022.
                                        3. Fact sheet: President Biden to Sign Historic Executive Order advancing LGBTQI+ equality during Pride Month. The White House. https://bit.ly/3yfS6Kf. Published June 15, 2022. Accessed June 23, 2022.
                                        4. Palefsky JM, Lee JY, Jay N, et al. Treatment of anal high-grade squamous intraepithelial lesions to prevent anal cancer. New England Journal of Medicine. 2022;386(24):2273-2282. doi:10.1056/nejmoa2201048
                                        5. Advance study. https://bit.ly/3Nbzu2p. Accessed June 23, 2022.
                                          6. 5 min
                                        6. Investigation of PBMs, Walmart raising wages for pharmacy technicians, and more!

                                          This week on Pharm5:

                                          • FTC launches investigation into PBMs
                                          • COVID vaccines coming soon for kids <5 years old
                                          • Paxlovid’s efficacy against COVID symptoms and mortality
                                          • C. diff with highly reduced vancomycin susceptibility
                                          • Walmart and Sam’s Club raising wages for pharmacy technicians


                                            • References:

                                            1. FTC launches inquiry into prescription drug middlemen industry. Federal Trade Commission. https://bit.ly/3NUjNxA. Published June 7, 2022. Accessed June 16, 2022.
                                            2. Jones A. APHA welcomes FTC study of PBMs' anticompetitive business practices – urges agency to take action. American Pharmacists Association. https://bit.ly/3MVUh9N. Published June 7, 2022. Accessed June 16, 2022.
                                            3. Park A, Ducharme J. Covid-19 vaccines for kids 6 months + up recommended by FDA. Time. https://bit.ly/3zGyUq4. Published June 15, 2022. Accessed June 16, 2022.
                                            4. Sarkissian A. Florida is the only state to skip pre-ordering covid-19 vaccines for kids. POLITICO. https://politi.co/3mTkUlf. Published June 15, 2022. Accessed June 16, 2022.
                                            5. Najjar-Debbiny R, Gronich N, Weber G, et al. Effectiveness of Paxlovid in reducing severe COVID-19 and mortality in high-risk patients. Clinical Infectious Diseases. June 2022. doi:10.1093/cid/ciac443.
                                            6. Person. Pfizer stops enrollment in PAXLOVID trial in standard-risk population. Reuters. https://reut.rs/3MZvmm3. Published June 14, 2022. Accessed June 16, 2022.
                                            7. Greentree DH, Rice LB, Donskey CJ. Houston, we have a problem: Reports of clostridioides difficile isolates with reduced vancomycin susceptibility. Clinical Infectious Diseases. June 2022. doi:10.1093/cid/ciac444.
                                            8. Kelly CR, Fischer M, Allegretti JR, et al. ACG clinical guidelines: Prevention, diagnosis, and treatment of Clostridioides difficile infections. American Journal of Gastroenterology. 2021;116(6):1124-1147. doi:10.14309/ajg.0000000000001278
                                            9. Johnson S, Lavergne V, Skinner AM, et al. Clinical practice guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on management of clostridioides difficile infection in adults. Clinical Infectious Diseases. 2021;73(5). doi:10.1093/cid/ciab549
                                            10. Host K, Jackson S. Walmart launches new approach to pharmacy tech wages with more frequent raises. Corporate. https://bit.ly/3xAf8da. Published June 16, 2022. Accessed June 16, 2022.
                                              11. 5 min

                                            About Pharm5

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                                            The top five things happening in pharmacy this week in five minutes or less! Hosted by assistant professor of pharmacotherapy and board certified ambulatory care pharmacist, Dr. Elizabeth B. Hearn.