Pharm5

By Elizabeth B. Hearn, PharmD, BCACP

The top five things happening in pharmacy this week in five minutes or less! Hosted by assistant professor of pharmacotherapy and board certified ambulatory care pharmacist, Dr. Elizabeth B. Hearn.... more

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FAQs about Pharm5:

How many episodes does Pharm5 have?

The podcast currently has 59 episodes available.

Pharm5 episodes:

August 19, 2022SPECIAL RELEASE: Updated CHEST Guidelines for Perioperative Management of Antithrombotic Therapy
This week on Pharm5:
What most pharmacists need to know about the newest CHEST Guidelines for Perioperative Management of Antithrombotic Therapy!

Connect with us!
Listen to our podcast: Pharm5

Watch us on TikTok: @LizHearnPharmD

Follow us on Twitter: @LizHearnPharmD

References:
Douketis JD, Spyropoulos AC, Murad MH, et al. Perioperative management of antithrombotic therapy: An american college of chest physicians clinical practice guideline. Chest. August 2022. doi:10.1016/j.chest.2022.07.025

Douketis JD, Spyropoulos AC, Spencer FA, et al. Perioperative management of antithrombotic therapy. Chest. 2012;141(2). doi:10.1378/chest.11-2298
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6min
August 12, 2022Inflation Reduction Act, Intradermal Jynneos, and more!
This week on Pharm5:
Inflation Reduction Act’s impact on Medicare Part D

Monkeypox and Jynneos vaccine updates

Tennessee sues Walgreens for opioid over-distribution

FDA declines Nuplazid’s indication for Alzheimer’s psychosis

Two BP readings better predicts ASCVD risk

References:
Statement by president Biden on Senate Passage of the inflation reduction act. The White House. https://bit.ly/3dcWRfs. Published August 7, 2022. Accessed August 11, 2022.

Part D Senior Savings Model (insulin savings) common questions & answers. https://go.cms.gov/3SGrKcx. Accessed August 11, 2022.

JYNNEOS vaccine. Centers for Disease Control and Prevention. https://bit.ly/3STVq6e. Published August 10, 2022. Accessed August 11, 2022.

FDA authorizes intradermal use of Jynneos vaccine for Monkeypox. Medscape. https://wb.md/3C2K9ua. Published August 9, 2022. Accessed August 11, 2022.

Assistant Secretary for Public Affairs (ASPA). Biden-Harris Administration Bolsters Monkeypox Response; HHS secretary Becerra declares public health emergency. HHS.gov. https://bit.ly/3pabFhK. Published August 5, 2022. Accessed August 11, 2022.

Williams J. Judge says Walgreens contributed to San Francisco's opioid crisis. PBS. https://to.pbs.org/3zMFH04. Published August 10, 2022. Accessed August 11, 2022.

Gorman S. Tennessee sues Walgreens Pharmacy chain over Opioid Distribution. Medscape. https://wb.md/3Qk2VkW. Published August 5, 2022. Accessed August 11, 2022.

Staff R. FDA declines to approve expanded use of antipsychotic drug. Medscape. https://wb.md/3bIlSz2. Published August 5, 2022. Accessed August 11, 2022.

Clark CE, Warren FC, Boddy K, et al. Higher arm versus lower arm systolic blood pressure and cardiovascular outcomes: A meta-analysis of individual participant data from the Interpress-IPD Collaboration. Hypertension. August 2022. doi:10.1161/hypertensionaha.121.18921.

Whelton P, Carey R, Aronow W, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. J Am Coll Cardiol. 2018 May, 71 (19) e127–e248. https://doi.org/10.1016/j.jacc.2017.11.006.
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5min
August 05, 2022OTC options for pets, monkeypox updates, historically low uninsured rates, and more!
This week on Pharm5:
Pfizer’s Phase 2 trials for revamped COVID vaccine

Monkeypox updates: vaccines and treatment options

Treating animal infections with OTC topical medications

Uninsured rates hit historic US low

ASHP’s guidance to prevent controlled substance diversion

References:
Pfizer and BioNTech advance COVID-19 vaccine strategy with study start of next-generation vaccine candidate based on enhanced spike protein design. Pfizer. https://bit.ly/3OVxagF. Published July 27, 2022. Accessed August 4, 2022.

FDA Briefing Document Vaccines and Related Biological Products Advisory Committee Meeting. https://bit.ly/3I1wZhY. Published June 28, 2022. Accessed June 30, 2022.

JYNNEOS monkeypox vaccine distribution by jurisdiction. https://bit.ly/3vBs0zt. Accessed August 4, 2022.

FDA provides update on agency response to Monkeypox Outbreak. U.S. Food and Drug Administration. https://bit.ly/3bw93rj. Published July 29, 2022. Accessed August 4, 2022.

Lundberg A, Koch SN, Bierbrier L, Slater M. Treating common skin conditions of cats and dogs in a community setting. Today's Veterinary Practice. 2022:100-106. Accessed August 4, 2022.

Spitnagel MB, Hillier A, Gober M, Carlson MD. Treatment complexity and caregiver burden are linked in owners of dogs with allergic/atopic dermatitis. Vet Dematol. 2021;32(2):192-e50. Accessed August 4, 2022.

Assistant Secretary for Public Affairs (ASPA). New HHS report shows national uninsured rate reached all-time low in 2022. HHS.gov. https://bit.ly/3zwU48y Published August 2, 2022. Accessed August 4, 2022.

Number of retail prescription drugs filled at pharmacies by payer. KFF. https://bit.ly/3QmntJ8 Published March 5, 2020. Accessed August 4, 2022.

ASHP releases revised guidelines on preventing diversion of controlled substances. ASHP. https://bit.ly/3d5XZ4F. Published August 2, 2022. Accessed August 4, 2022.
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5min
July 29, 2022COVID vaccines linked to fewer CV events, Paxlovid reimbursements, and more!
This week on Pharm5:
Polio in the US

COVID vaccines linked to fewer CV events

Vancomycin AUC vs. target troughs

CMS Star Ratings 2022

Payment model is needed for Paxlovid prescribing

Use APhA’s pre-written, editable letter to advocate for pharmacist reimbursement for Paxlovid prescribing: https://bit.ly/3cKwm0O

References:
Meko H. First polio case in nearly a decade is detected in New York State. The New York Times. https://nyti.ms/3JbGLid. Published July 21, 2022. Accessed July 28, 2022.

Polio vaccine effectiveness and duration of protection. Centers for Disease Control and Prevention. https://bit.ly/3JhiIyy. Published May 4, 2018. Accessed July 28, 2022.

Kim Y-E, Huh K, Park Y-J, Peck KR, Jung J. Association between vaccination and acute myocardial infarction and ischemic stroke after COVID-19 infection. JAMA. July 2022. doi:10.1001/jama.2022.12992

Abdelmessih E, Patel N, Vekaria J, et al. Vancomycin area under the curve versus trough only guided dosing and the risk of acute kidney injury: Systematic Review and meta‐analysis. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. July 2022. doi:10.1002/phar.2722

Chung D, Efta J, Brunsman A, et al. Evaluation of pharmacist time dedicated to vancomycin dosing in adult patients using a 24-hour AUC nomogram or Trough Monitoring Approach: A time motion study. American Journal of Health-System Pharmacy. 2022;79(14):1173-1179. doi:10.1093/ajhp/zxac094

Press release CMS releases 2022 Medicare Advantage and Part D star ratings to help Medicare beneficiaries compare plans. CMS. https://go.cms.gov/3oEzpKM. Accessed July 28, 2022.

Emergency action is necessary to provide payment for pharmacist prescribing of Paxlovid. OneClickPolitics. https://bit.ly/3cKwm0O. Accessed July 28, 2022.
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5min
July 22, 2022Pharmacy's Response to HHS Guidance for Retail Pharmacies and more!
This week on Pharm5:
Concerns with HHS guidance to retail pharmacies

Drug overdose disparities

Antimicrobial resistance after COVID-19

Colloid v. crystalloid during cardiac surgery

Novavax endorsed by CDC

References:
Christensen J. Biden administration says pharmacies can't turn away people who have a prescription for a drug that may end a pregnancy. CNN. https://cnn.it/3olj1id. Published July 13, 2022. Accessed July 14, 2022.

ASHP response and advocacy related to recent federal guidance to "retail pharmacies" on access to Reproductive Health. ASHP. https://bit.ly/3RQHusT. Accessed July 21, 2022.

Drug overdose deaths rise, Disparities Widen. Centers for Disease Control and Prevention. https://bit.ly/3PNKSTP. Accessed July 21, 2022.

U.S. must curb rising rate of resistance to antimicrobials. IDSA Home. https://bit.ly/3PKz5FS. Accessed July 21, 2022.

Covid-19: U.S. impact on Antimicrobial Resistance, Special Report 2022. June 2022. doi:10.15620/cdc:117915

Pesonen E, Vlasov H, Suojaranta R, et al. Effect of 4% albumin solution vs Ringer acetate on major adverse events in patients undergoing cardiac surgery with cardiopulmonary bypass. JAMA. 2022;328(3):251. doi:10.1001/jama.2022.10461

CDC recommends Novavax's COVID-19 vaccine for adults. Centers for Disease Control and Prevention. https://bit.ly/3zm4Tv4. Published July 19, 2022. Accessed July 21, 2022.
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5min
July 15, 2022Updates on Roe V. Wade, Novavax, monkeypox, and more!
This week on Pharm5:
Pharmacists not required to turn away teratogenic prescriptions

New, protein-based COVID-19 vaccine receives EUA

Monkeypox update

Delaware HB399 for Pharmacists Test and Treat

BPS scores released

References:
Christensen J. Biden administration says pharmacies can't turn away people who have a prescription for a drug that may end a pregnancy. CNN. https://cnn.it/3olj1id. Published July 13, 2022. Accessed July 14, 2022.

Coronavirus (COVID-19) update: FDA authorizes emergency use of Novavax COVID-19 vaccine, adjuvanted. U.S. Food and Drug Administration. https://bit.ly/3B5SNb5. Accessed July 14, 2022.

2022 U.S. Map & Case count. Centers for Disease Control and Prevention. https://bit.ly/3aG6h2i. Published July 13, 2022. Accessed July 14, 2022.

Fact sheet: Biden-Harris Administration's Monkeypox Outbreak response. The White House. https://bit.ly/3o2hYTX. Published June 29, 2022. Accessed July 14, 2022.

Dem, D. House passes pharmacist test to treat bill. Blue Delaware. https://bit.ly/3uNocLr. Published June 17, 2022. Accessed July 14, 2022.

Pharmacist prescribing: "test and treat". NASPA. https://bit.ly/3Rw9e6b. Published July 11, 2022. Accessed July 14, 2022.

Board of Pharmacy Specialties (BPS) homepage. Board of Pharmacy Specialties. https://bit.ly/3z4QOC6. Accessed July 14, 2022.
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4min
July 08, 2022Pharmacists prescribing Paxlovid, flu shot updates for elderly, and more!
This week on Pharm5:
Pharmacists prescribing Paxlovid

New oncology payment model from CMS

Flu shot updates for ≥65 years old

Conflicting mortality and morbidity data for LVADs in heart failure

Cardiometabolic trends in the 2000s

References:
Coronavirus (COVID-19) update: FDA authorizes pharmacists to prescribe paxlovid with certain limitations. U.S. Food and Drug Administration. https://bit.ly/3AuDqbB. Published July 6, 2022. Accessed July 7, 2022.

Enhancing oncology model: CMS innovation center. Innovation Center. https://bit.ly/3yq4bLD. Published June 27, 2022. Accessed July 7, 2022.

CDC director adopts preference for specific flu vaccines for seniors. Centers for Disease Control and Prevention. https://bit.ly/3ynmotw. Published June 30, 2022. Accessed July 7, 2022.

https://bit.ly/3yOSrUE

Vidula H, Takeda K, Estep JD, et al. Hospitalization patterns and impact of a magnetically-levitated left ventricular assist device in the momentum 3 trial. JACC. https://bit.ly/3yQVY4R. Published July 1, 2022. Accessed July 7, 2022.

Cogswell R, Rogers JG, M.R. M, et al. Residual heart failure on mechanically assisted circulation: A call to action. JACC. https://bit.ly/3yOSrUE. Published July 1, 2022. Accessed July 7, 2022.

O’Hearn M, Lauren BN, Wong JB, Kim DD, Mozaffarian D. Trends and disparities in cardiometabolic health among U.S. adults, 1999-2018. Journal of the American College of Cardiology. 2022;80(2):138-151. doi:10.1016/j.jacc.2022.04.046
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5min
July 01, 2022Implications of Roe v. Wade, Fall 2022 COVID Booster, and more!
This week on Pharm5:
Roe v. Wade overturned

ASHP’s response and conflicts of interest

Fall 2022 COVID-19 booster update

USPSTF vitamin recommendation statement

Qsymia for obesity in youth

References:
Supreme Court of the United States. https://bit.ly/3u80DfV. Accessed June 30, 2022.

MacNaughton H, Nothnagle M, Early J.

Mifepristone and Misoprostol for early pregnancy loss and medication abortion. American Family Physician. https://bit.ly/3I2ASmQ. Published April 15, 2021. Accessed June 29, 2022. ASHP Calls for Patients’ Rights to Access Reproductive Health Services. ASHP. https://bit.ly/3NvI7oz. Accessed June 29, 2022.

Legislators We Support. ASHP. https://bit.ly/3I9FN5x. Accessed June 29, 2022.

Carter: Life wins! Congressman Buddy Carter. https://bit.ly/3y59mk7. Published June 24, 2022. Accessed June 29, 2022.

@SC_PharmD Oh god I already hate it here https://twitter.com/SC_PharmD/status/1542121672546717696. Posted June 29, 2022.

FDA Briefing Document Vaccines and Related Biological Products Advisory Committee Meeting. https://bit.ly/3I1wZhY. Accessed June 30, 2022.

Lafraniere S, Weiland N. F.D.A. advisers recommend updated boosters targeting forms of Omicron. The New York Times. https://nyti.ms/3I3sljt. Published June 28, 2022. Accessed June 29, 2022.

Mangione CM, Barry MJ, Nicholson WK, et al. Vitamin, mineral, and multivitamin supplementation to prevent cardiovascular disease and cancer. JAMA. 2022;327(23):2326. doi:10.1001/jama.2022.8970

Childhood Obesity Facts. Centers for Disease Control and Prevention. https://bit.ly/3Ox33gf. Published May 17, 2022. Accessed June 30, 2022.

FDA approves Qsymia for treating teens with obesity. Medscape. https://wb.md/3a5ywXY. Published June 28, 2022. Accessed June 30, 2022.

Qsymia. Package Insert. Vivus, LLC; 2022.
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4min
June 24, 2022Medicare Part D vs. Mark Cuban, MSM can donate blood in the ADVANCE study, and more!
This week on Pharm 5:
Medicare Part D overpaying by $3.6B vs. Mark Cuban

Vaxneuvance Pneumococcal-15 for kids

Healthcare Implications from Biden’s LGBTQI+ Executive Order

ANCHOR Study reduces progression to anal cancer by 57% in PLWH and HSIL

ADVANCE Study enrollment open for MSM interested in donating blood

References:
Lalani HS, Kesselheim AS, Rome BN. Potential medicare part D savings on generic drugs from the Mark Cuban Cost Plus Drug Company. Annals of Internal Medicine. 2022. doi:10.7326/m22-0756

Merck & Co., Inc. U.S. FDA Approves Merck’s VAXNEUVANCETM (Pneumococcal 15-valent Conjugate Vaccine) for the Prevention of Invasive Pneumococcal Disease in Infants and Children. Merck.com. https://bit.ly/3tXVlDL. Published June 22, 2022. Accessed June 23, 2022.

Fact sheet: President Biden to Sign Historic Executive Order advancing LGBTQI+ equality during Pride Month. The White House. https://bit.ly/3yfS6Kf. Published June 15, 2022. Accessed June 23, 2022.

Palefsky JM, Lee JY, Jay N, et al. Treatment of anal high-grade squamous intraepithelial lesions to prevent anal cancer. New England Journal of Medicine. 2022;386(24):2273-2282. doi:10.1056/nejmoa2201048

Advance study. https://bit.ly/3Nbzu2p. Accessed June 23, 2022.
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5min
June 17, 2022Investigation of PBMs, Walmart raising wages for pharmacy technicians, and more!
This week on Pharm5:
FTC launches investigation into PBMs

COVID vaccines coming soon for kids <5 years old

Paxlovid’s efficacy against COVID symptoms and mortality

C. diff with highly reduced vancomycin susceptibility

Walmart and Sam’s Club raising wages for pharmacy technicians

References:
FTC launches inquiry into prescription drug middlemen industry. Federal Trade Commission. https://bit.ly/3NUjNxA. Published June 7, 2022. Accessed June 16, 2022.

Jones A. APHA welcomes FTC study of PBMs' anticompetitive business practices – urges agency to take action. American Pharmacists Association. https://bit.ly/3MVUh9N. Published June 7, 2022. Accessed June 16, 2022.

Park A, Ducharme J. Covid-19 vaccines for kids 6 months + up recommended by FDA. Time. https://bit.ly/3zGyUq4. Published June 15, 2022. Accessed June 16, 2022.

Sarkissian A. Florida is the only state to skip pre-ordering covid-19 vaccines for kids. POLITICO. https://politi.co/3mTkUlf. Published June 15, 2022. Accessed June 16, 2022.

Najjar-Debbiny R, Gronich N, Weber G, et al. Effectiveness of Paxlovid in reducing severe COVID-19 and mortality in high-risk patients. Clinical Infectious Diseases. June 2022. doi:10.1093/cid/ciac443.

Person. Pfizer stops enrollment in PAXLOVID trial in standard-risk population. Reuters. https://reut.rs/3MZvmm3. Published June 14, 2022. Accessed June 16, 2022.

Greentree DH, Rice LB, Donskey CJ. Houston, we have a problem: Reports of clostridioides difficile isolates with reduced vancomycin susceptibility. Clinical Infectious Diseases. June 2022. doi:10.1093/cid/ciac444.

Kelly CR, Fischer M, Allegretti JR, et al. ACG clinical guidelines: Prevention, diagnosis, and treatment of Clostridioides difficile infections. American Journal of Gastroenterology. 2021;116(6):1124-1147. doi:10.14309/ajg.0000000000001278

Johnson S, Lavergne V, Skinner AM, et al. Clinical practice guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on management of clostridioides difficile infection in adults. Clinical Infectious Diseases. 2021;73(5). doi:10.1093/cid/ciab549

Host K, Jackson S. Walmart launches new approach to pharmacy tech wages with more frequent raises. Corporate. https://bit.ly/3xAf8da. Published June 16, 2022. Accessed June 16, 2022.
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5min

FAQs about Pharm5:

How many episodes does Pharm5 have?

The podcast currently has 59 episodes available.