Pharmacy Podcast Network

Pharmacy Podcast Network

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Pharmacy Podcast Network episodes

  • Exploring GLP-1 Agonists: Sports Pharmacology and Beyond with Dr. Jesica Mills | Sports Pharmacy Podcast

    In this episode of "glp1 with Jesica Mills", Dr. H and Dr. Jesica Mills plunge into an in-depth exploration of GLP-1 (Glucagon-like peptide-1) agonists and their intriguing role in sports pharmacology. Learn about the complexities of these medications, their contribution to diabetes management, and their influence on weight loss. Learn how GLP-1 agonists are becoming a topic of interest due to their interaction with the beta cells of the pancreas, regulating blood sugar levels, and how diet and lifestyle tangibly affect the production of GLP-1 in the body.


    Listen to our discussions surrounding the potential side effects, the need for careful monitoring, the off-label uses of these medications, and their potential implications. Further delve into the alternatives to GLP-1 agonists like acarbose and natural approaches to boost GLP-1 levels employing over-the-counter supplements like berberine and lifestyle adjustments. The conversation extends to understanding the lymphatic system, the importance of routine checkups, lab tests, and the role of micronutrients. Join us on this captivating itinerary exploring the beneficial yet challenging world of GLP-1 agonists!

    57 min
  • Leveraging Long Term Care at Home Network | Happier at Home PRN
    Long-Term Care at Home Pharmacy Network 

    Lindsay Dymowski Constantino
    President, Co-founder 

    Lindsay is a dynamic pharmacy leader who drives strategic initiatives, fosters industry-wide collaboration, and advocates passionately for optimal patient care. With a deep-rooted connection to community pharmacy, extensive ownership experience spanning more than 10 years and her pioneering role in the long-term care at home market, Lindsay has been a driving force in advancing healthcare innovation and elevating the role of community pharmacy in shaping the future of patient-centered care.
    New boost
    28 min
  • The Extra Dose: User Conference Post-Show Part Two | Framework Focus

    This is part two of the three-part FrameworkLTC User Conference Post-Show series. This series is hosted by the Pharmacy Podcast Network’s own Todd Eury. In this series, Todd chats with SoftWriters’ team members, exhibitors, partners, and conference attendees live from the show floor. This episode features Joshua Porter, Grace Ball, Julie Martin, Matt Gilbert, and Nick Majors. 

    26 min
  • Understanding Insufficient GLP-1 Activity in T2D | T2D: Don’t Sugar Coat It

    What is the impact of insufficient GLP-1 activity in type 2 diabetes (T2D)? Join experts in T2D: Dr John Anderson, Dr Javier Morales, and Dr Richard Pratley as they review the role of GLP-1 in glucose regulation, consider the impact of insufficient GLP-1 activity on pancreatic beta cells in patients with T2D, and discuss possibilities to overcome insufficient GLP-1 activity in patients with T2D.

     

    John E. Anderson, MD

  • Javier Morales, MD, FACP, FACE

  • Richard Pratley, MD

     

    10 min
  • When you just can’t figure out your ”Why” | PharmXcel


    How can you figure out your Why?

    Can you live for more than one Cause?

    Is your Pharmacy career externally or internally driven?

    The importance of spending time to figure out your Why

    References:

    Book - Simon Sinek: The Infinite Game

    Book - Sonja Lyubomirsky: The How of Happiness: A New Approach to Getting the Life You Want

    Visit www.katrinaazer.com to find out how I can help you to:

    👉 Figure out what your purpose is and how you can weave that into your career

    👉 Get coached into figuring out and building your dream career

    👉 Find out how to build a side hustle that earns you income

    👉 Bring Pharmacogenomics & Telepharmacy to your practice

    Follow me on social media:

    ➡️ LinkedIn: https://www.linkedin.com/in/katrina-azer/

    ➡️ Facebook: https://www.facebook.com/pharmxcel

    ➡️Twitter: https://twitter.com/Kat_pharmacist

    The PharmXcel Podcast is a show for pharmacists who want to connect with why they did pharmacy and how to build a fulfilling career by addressing the opportunities and challenges that make us pharmacists—Pharmacists who signed up for pharmacy to help transform patient lives!

    Thanks for listening in—it means the world to me!

    Here is how you can support my mission:

    Give it a 5-star rating wherever you’re listening to it

    Share this with other Pharmacists who would enjoy it

    Subscribe to get notified of new episodes

    And please reach out if you have any questions or comments!

    Your feedback will help me bring you valuable content

    17 min
  • From ACPHS to Precision Genomics Oncology | Occupation Station
    In this episode of Occupation Station, host Diane Donato speaks with Christopher Fausel '96, Director of Pharmacy, Precision Genomics Oncology at Indiana University Simon Comprehensive Cancer Center. The ACPHS graduate delves into the fascinating world of precision medicine, where tumor DNA is analyzed to create personalized treatment plans. While the field presents challenges due to its rapid evolution, Fausel finds his work helping cancer patients extremely gratifying and sees a future of unlimited possibilities. He talks about his decision to become a pharmacist, his studies at ACPHS, and how his work at Stratton V.A. in Albany were all precursors to his current position. Fausel encourages pharmacy students to explore diverse opportunities during their residencies and embrace emerging technologies. Fausel's story is an inspiring reminder that pharmacy careers offer endless possibilities for making a meaningful impact on patients' lives.
      
    I attach the 1080x1080 social media tile and some audiograms that could be used to tease the episode on your social media platforms. Here is some copy for the audiograms:
     
    Fausel 1
    Join us for an insightful conversation with Christopher Fausel ’93 ‘96, Director of Pharmacy at Indiana University Simon Comprehensive Cancer Center. Discover the remarkable rewards of working with cancer patients, as well as Christopher's inspiring career journey. Find out how tumor DNA analysis is transforming personalized treatment plans. https://tinyurl.com/5cb82yzf
     
    Fausel 2
    Get ready to dive into the fascinating world of precision medicine with Christopher Fausel '93 '96, Director of Pharmacy at Indiana University Simon Comprehensive Cancer Center. Discover how tumor DNA analysis is revolutionizing personalized treatment plans. And be inspired by Fausel's advice to pharmacy students to keep an open mind to all the incredible opportunities that await! https://tinyurl.com/5cb82yzf
    26 min
  • From PharmD to Pharmacogenomics Test Developer: Dr. Thierry Dervieux’s Story of Revolutionizing Healthcare Through Precision Medicine for Immune Modulated Inflammatory Diseases | PGx For Pharmacists

    Becky Winslow, BS, PharmD Host and Pharmacogenomics Medical Science Liaison; Behnaz Sarrami, MS, PharmD, Host and Pharmacogenomics Medical Science Liaison; Thierry Dervieux, PharmD, PhD, Chief Scientific Officer at Prometheus Laboratories

    In this episode of the PGX for Pharmacists Podcast, Dr. Thierry Dervieux, Dr. Behnaz Sarrami, and I discuss Dr. Dervieux’s career as a PharmD,

    PhD, and chief scientific officer who has designed a pharmacogenomics test prescribers may use to optimize biosimilars for autoimmune gastrointestinal diseases. Dr. Dervieux will illustrate to our audience pharmacogenomics’ potential beyond Tier 1 and 2 genetic testing by describing the clinical validity and utility of his laboratory’s suite of tests in the autoimmune gastrointestinal disease diagnosis and treatment market. Behnaz and I hope this episode will inspire pharmacists interested in pharmacogenomics to think beyond the boxed PGx test most laboratories offer when they think about PGx and consider all the biological systems in which genetics impacts drugs’ efficacy and safety.



    Disclaimer:
    Behnaz Disclaimer: These are my personal views and opinions, and I am not speaking on behalf of Castle Biosciences, Inc. Becky Disclaimer: These are my personal views and opinions, and I am not speaking on behalf of any other entity.

     

    Transcription:

    1

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    You're listening to the Pharmacy podcast Network in a world where one size fits all medications dominate the pharmaceutical industry.

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    Precision medicine brings a ray of hope for those seeking customized health care.

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    Pharmacists have a unique opportunity to help people in need of specialized testing to ensure medications work as intended.

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    Welcome to PGX for pharmacists where we unravel the wonders of precision medicine and its potential to revolutionize the way we approach pharmacy care.

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    Get ready to uncover the secrets behind pharmacogenomics and how it's transforming lives one genome at a time.

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    Hello,

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    everyone.

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    I'm your host,

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    Doctor Becky Winslow.

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    And you're listening to the PGX for Pharmacist podcast that we magazine recognized in 2021 as the ninth most listened to genetics podcasts in the world on the PGX for Pharmacist podcast.

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    We explore all things pharmacogenomics related and our mission is to educate and advocate for PGX.

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    We accomplish this mission through exclusive interviews with highly qualified and well experienced pharmacogenomics.

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    Industry leaders such as today's special guest and my name is Baas Sami,

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    the co-host of PGX for Pharms podcast,

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    Pharmacogenomics,

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    medical science liaison and a mentor to pharmacist.

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    Connect with us on linkedin and let's get a conversation going.

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    We want to hear from you and how you're impacting pharmacogenomic stakeholders and what you have learned throughout your journey.

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    Ok.

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    So without any further ado,

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    I'm extremely pleased to introduce to our audience.

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    Doctor Theory Devo,

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    the Chief Scientific Officer at Prometheus Laboratories,

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    and Perme Prometheus Laboratories is a reference clinical laboratory that's focused on the diagnosis,

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    prognosis and monitoring of immune mediated inflammatory diseases.

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    So,

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    thank you,

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    Doctor De for joining us on the podcast.

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    Today.

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    I'm excited to share your and Prometheus's story with our audience.

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    Um in particular,

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    I'm excited about you sharing your career journey as a farm D phd and Chief scientific officer and designer of the Predictor PK AD A which is a precision guided dosing test for the optimization of Humira Remicade and their bio cylinders.

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    So,

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    one of Bana's and my main goals for this episode of the PGX for Pharmacist podcast is to expand our audience's notion of what a PGX test looks like and to inspire them to think bigger than the traditional box PGX test.

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    Most of them or most of you are uh familiar with.

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    So,

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    Doctor D uh I'd like to start the podcast by having our guests um introduce themselves and elaborate on how you are a pharmacogenomics expert.

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    Yeah,

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    thank you,

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    Becky for having me.

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    Uh uh Yes.

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    So I am a,

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    I am a pharmacist uh with uh a family who is a,

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    a doctorate in pharmacokinetics.

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    Uh I completed my studies in France and I came as a postdoc uh fellow uh to work in the United States about 20 years ago to work on the pharmacogenomic of anti cancer agents,

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    uh primarily uh six Maturin as well as methotrexate.

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    After my post doc,

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    uh I moved uh in industry for promet.

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    So I have a large experience in uh uh the implementation of pharmacogenetics testing in immune mediated inflammatory disease.

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    Our lab Rome was the first uh clinical laboratory in the United States to offer the fin uh metyl transfer genotyping as well as the thin metabolites.

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    So,

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    uh uh of uh of 70 publications in the field and uh I'm very uh very excited to have uh to be on the postcard with you uh uh today.

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    All right.

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    So thank you for qualifying yourself as an expert.

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    So,

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    let's jump right in and delve into your current PGX work.

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    So,

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    if you'll tell us um a little about Prometheus,

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    specifically,

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    what is Prometheus's mission?

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    And how are you guys going about accomplishing your mission?

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    Yeah,

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    sure.

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    Uh So Promet is a,

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    is a reference uh clinical laboratory based in Southern California in San Diego.

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    Uh The company has been there for uh over 25 years.

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    We are uh specialize in the differential diagnosis of autoimmune G I disease uh disorders,

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    uh gastrointestinal disorder,

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    uh and inflammatory bowel disease.

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    And over the years,

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    we have developed a portfolio of a differentiated solution to facilitate the diagnosis,

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    the prognosis,

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    the monitoring,

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    as well as therapy selection with pharmacogenetics testing,

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    which we are offering to our clinical laboratory.

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    And most importantly,

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    uh recently,

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    we are uh uh developing some uh uh testing solution with the credit topic care test to optimize treatment to uh biologics.

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    Ok.

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    Well,

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    that,

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    that's great.

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    Can you also tell us uh about the Prois Library of Precision Medicine Tests for inflammatory bowel disease for patients?

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    how they benefit medication therapy management.

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    Stakeholders across the IB DS patients journey from diagnosis to treatment to disease,

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    monitoring through remission and how they differ from other lab tests for IBD and his treatments.

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    Yes.

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    So,

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    so we uh our,

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    our clinical laboratory offers some uh highly specialized test to facilitate the,

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    the diagnostic of uh to facilitate the differential diagnosis of uh uh inflammatory bowel disease.

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    So we are following uh testing solution with uh serological testing,

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    for example,

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    uh uh piana as as as well as uh macro microbial uh uh antibodies that are present uh uh in Crohn's disease as well as uh over uh auto uh auto antibodies that are present in er colitis.

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    These are conditions that are uh uh somewhat difficult to treat.

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    Uh And uh we are uh uh offering those tests to uh help uh gastroenterologist.

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    Uh uh first of all,

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    to establish a differential diagnosis of IBD as compared to other uh condition typically uh uh irritable bowel syndrome as well as over gastrointestinal disorder.

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    When the diagnostic is established,

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    uh we offer uh testing to uh establish a prognosis where we're gonna in inform the clinician that the patient has a more aggressive uh disease that will require more aggressive treatment where uh we can uh provide the testing solution to initiate uh uh the most appropriate therapy for uh for the patient uh with uh a testing where we are uh basically uh you know,

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    establish de determining some genotyping with the fit transferal genotyping.

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    For example,

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    where we can uh indicate that the patient is,

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    is likely uh to present with a side effect to those medication.

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    And once you know,

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    the the treatment is initiative,

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    we have a portfolio of solution uh to facilitate the monitoring of the disease of the inflammatory bowel disease as well as the dosing optimization with uh uh the answer test which uh measure blood level uh for uh uh monoclonal antibodies that are indicated in the treatment of IB start with starting with Infliximab Adalimumab as well as uh Tein and vidal.

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    So we have a comprehensive portfolio to uh to surround the clinician with uh a variety of testing solution.

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    With our goal being to improve the uh the outcome uh of patients with uh with diabetes.

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    And I think that the pharmacist has a very important role to play from that perspective.

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    So theory,

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    could you elaborate for us more on the predictor test?

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    Um especially since you designed that test,

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    we'd really like to know,

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    um you know,

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    what did that take and what role does it play in your suite of testing?

    117

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    Yeah.

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    Sure.

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    So the,

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    the,

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    the,

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    the,

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    the predictor test is uh uh is uh is utilized when the patient is receiving treatment.

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    It's been speci specifically designed to optimize uh biological uh uh disease modifiers such as Infliximab adalimumab that are co therapies in the treatment of inflammatory bowel disease as well as other immune uh mediated inflammatory.

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    This is what the test does is to you connect the blood specimen,

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    uh you know,

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    with dosing information.

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    And what we do is to uh uh provide guidance uh to clinician with uh respect of the best dose to give in order to achieve the best the level which is the most consistent with uh uh the disease control that needs to be achieved for the patient.

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    Typically a vast majority,

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    about two third of a third to two third,

    131

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    a third of patient uh tend to be uh uh unresponsive uh to this uh very expensive medication.

    132

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    Uh Not because they don't have the uh you know,

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    typically because they have a,

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    you know,

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    pharmacokinetic uh suboptimal pharmacokinetic uh that makes them uh you know,

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    unresponsive because uh not enough drug has been given.

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    So what we do with a predictor test is to basically estimate the pa the pharmacokinetic uh parameter for the patient.

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    And from then uh re report the best dose uh to give in order to achieve the,

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    the level which is consistent with the uh the most uh uh effective disease control to be achieved for the patient.

    140

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    So we are offering,

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    we have developed a test for the Infliximab as well as Adalimumab which is Humira,

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    but these are antimony causes factor.

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    And we are also developing the test for vidur as well as uh is that are widely used also in the treatment of,

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    of uh inflammatory bubble disease.

    145

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    Wow,

    146

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    uh for MET is a suite of tests.

    147

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    Goes well beyond um the PGX testing that our audience is most familiar with,

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    uh which typically only includes snips for cyp genes and some pharmacodynamic genes.

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    This is really exciting um genes and biomarkers related to immunology are not commonly found in what I call the box PGX tests such as those uh made by large uh laboratory manufacturing companies um where the panel has a set number of genes and uh you know,

    150

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    it was developed by a larger laboratory for maybe smaller laboratories use.

    151

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    So my understanding,

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    having talked with you extensively theory is that immunology has fewer PGX test available because it's actually more difficult say than oncology to research and develop tests.

    153

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    So,

    154

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    could you elaborate for our audience on the difficulties that are associated with immunology,

    155

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    research and developing tests uh for immunology versus say oncology?

    156

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    Yeah,

    157

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    sure.

    158

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    So in uh in immunology,

    159

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    as compared to oncology,

    160

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    there is no such a thing such as a somatic mutation where for example,

    161

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    you're gonna have a behalf,

    162

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    you know,

    163

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    that indicates that the patient,

    164

    00:12:20,679 --> 00:12:20,919
    you know,

    165

    00:12:20,929 --> 00:12:25,239
    is likely to benefit or not from some treatment in immunology.

    166

    00:12:25,250 --> 00:12:26,750
    This is far more complicated,

    167

    00:12:26,760 --> 00:12:28,830
    complicated for the reason,

    168

    00:12:29,239 --> 00:12:31,020
    starting with uh the fact that,

    169

    00:12:31,030 --> 00:12:31,179
    you know,

    170

    00:12:31,190 --> 00:12:36,219
    the response to this uh medication uh are multifactorial.

    171

    00:12:36,260 --> 00:12:37,820
    And the fact that uh you know,

    172

    00:12:37,830 --> 00:12:39,380
    the mutation that uh the,

    173

    00:12:39,390 --> 00:12:39,619
    the,

    174

    00:12:39,630 --> 00:12:45,190
    the single nucleotide polymorphism in the GM line which uh uh you know,

    175

    00:12:45,200 --> 00:12:52,429
    can potentially associate with uh with outcome uh uh uh uh a lo in advance,

    176

    00:12:52,440 --> 00:12:58,359
    meaning that uh they're gonna have a weak association uh with a response to those medications.

    177

    00:12:58,369 --> 00:13:09,609
    So there is a necessity in immunology to combine multiple genetic polymorphism together in order to achieve uh some uh performances characteristics that will make uh you know,

    178

    00:13:09,619 --> 00:13:09,859
    the,

    179

    00:13:09,869 --> 00:13:10,380
    the,

    180

    00:13:10,390 --> 00:13:10,520
    the,

    181

    00:13:10,530 --> 00:13:13,219
    the clinician uh you know,

    182

    00:13:13,419 --> 00:13:15,619
    uh order the test and most importantly,

    183

    00:13:15,630 --> 00:13:15,840
    the,

    184

    00:13:15,849 --> 00:13:16,179
    the,

    185

    00:13:16,190 --> 00:13:17,739
    the payer to pay for the test.

    186

    00:13:17,750 --> 00:13:20,469
    So this field has been uh you know,

    187

    00:13:20,479 --> 00:13:20,679
    is,

    188

    00:13:20,690 --> 00:13:21,705
    is moving for,

    189

    00:13:21,715 --> 00:13:21,994
    you know,

    190

    00:13:22,005 --> 00:13:24,575
    there are some tests that are being developed right now.

    191

    00:13:24,924 --> 00:13:39,034
    But the biggest challenge is to be able to achieve again the the threshold of uh of performance that makes the test is variable enough uh to be uh again ordered by the clinician and the utilize uh to the benefit of the patient.

    192

    00:13:39,659 --> 00:13:41,200
    I couldn't agree with you more.

    193

    00:13:41,210 --> 00:13:53,489
    Um I've worked on the payer side or market access side of pharmacogenomics and even uh with a box test for which there's um a lot of research data available,

    194

    00:13:53,500 --> 00:13:55,119
    even with those,

    195

    00:13:55,130 --> 00:13:59,760
    it's sometimes difficult uh to get payers um to see the value.

    196

    00:13:59,770 --> 00:14:01,640
    So I absolutely agree with you.

    197

    00:14:01,940 --> 00:14:03,679
    Um The fact that you guys are,

    198

    00:14:03,690 --> 00:14:11,789
    are uh investing in producing the data necessary says a lot about your laboratory.

    199

    00:14:11,979 --> 00:14:12,559
    Um you know,

    200

    00:14:12,570 --> 00:14:15,380
    and how committed you are to this testing and,

    201

    00:14:15,390 --> 00:14:17,320
    and how you believe in the testing.

    202

    00:14:18,039 --> 00:14:23,640
    So I just want to make sure that our audience recognizes that,

    203

    00:14:24,359 --> 00:14:24,619
    you know,

    204

    00:14:24,630 --> 00:14:31,820
    Prometheus doesn't simply provide tests to determine if drugs for IBD will be effective and safe.

    205

    00:14:32,190 --> 00:14:36,900
    Um And maybe what the dose of the drug should be for the patient,

    206

    00:14:36,909 --> 00:14:40,219
    but you have that whole suite of tests.

    207

    00:14:40,229 --> 00:14:47,380
    Um the diagnostic test for the differential diagnosis all the way through remission.

    208

    00:14:48,030 --> 00:14:53,390
    So can you elaborate you elaborated on it some in the previous question?

    209

    00:14:53,400 --> 00:15:01,229
    But um can you tell us the difference between how you had to actually develop the test?

    210

    00:15:01,520 --> 00:15:02,530
    Um You didn't,

    211

    00:15:02,539 --> 00:15:03,059
    in other words,

    212

    00:15:03,070 --> 00:15:10,659
    purchase a test from another manufacturer with the biomarkers that you include in your testing.

    213

    00:15:10,669 --> 00:15:16,830
    Can you elaborate on how much more difficult it is to to develop a test from scratch?

    214

    00:15:18,169 --> 00:15:18,320
    Yeah,

    215

    00:15:18,330 --> 00:15:18,659
    sure.

    216

    00:15:18,669 --> 00:15:18,809
    I mean,

    217

    00:15:18,820 --> 00:15:22,070
    this is this is challenging for multiple and first of all,

    218

    00:15:22,080 --> 00:15:23,130
    you need to have the,

    219

    00:15:23,419 --> 00:15:27,450
    you need to have a clinical data set available with specimen available.

    220

    00:15:27,460 --> 00:15:28,159
    Uh you know,

    221

    00:15:28,169 --> 00:15:28,780
    in front,

    222

    00:15:28,859 --> 00:15:29,770
    obviously,

    223

    00:15:29,859 --> 00:15:30,890
    available.

    224

    00:15:31,200 --> 00:15:35,890
    Uh So we are leveraging a pro meters a large bi bank of specimen.

    225

    00:15:36,299 --> 00:15:37,190
    Uh as I said,

    226

    00:15:37,200 --> 00:15:39,719
    Prometheus has been founded 25 years ago.

    227

    00:15:39,729 --> 00:15:40,599
    So over the,

    228

    00:15:40,760 --> 00:15:41,919
    the past two decades,

    229

    00:15:41,929 --> 00:15:54,849
    we have been able to assemble a large uh substrate of data and specimen which we are uh uh using to uh uh establish our proof of concept if you will.

    230

    00:15:54,859 --> 00:16:07,559
    And then when we have uh identify some genetic polymorphism that are uh adequately uh associated with uh uh disease outcome and disease progression as well as uh toxicity.

    231

    00:16:07,969 --> 00:16:11,469
    Then we are entering validation phase where we are uh you know,

    232

    00:16:11,570 --> 00:16:14,789
    using validation cohorts where we are again,

    233

    00:16:14,969 --> 00:16:22,630
    combining multiple modalities together uh patient demographic as well as genetic marker together with theological marker.

    234

    00:16:22,640 --> 00:16:23,190
    Actually,

    235

    00:16:23,500 --> 00:16:27,419
    to come up with some Multivariate models that are uh again,

    236

    00:16:27,429 --> 00:16:39,250
    bringing the performances characteristics of the pharmacogenomic test or its combination with our marker to the level where it's supposed to be in the first place to meet uh uh payer.

    237

    00:16:39,650 --> 00:16:41,190
    And uh obviously,

    238

    00:16:41,200 --> 00:16:41,760
    again,

    239

    00:16:41,770 --> 00:16:45,320
    the patient uh to the benefit of the patient and to,

    240

    00:16:45,330 --> 00:16:46,619
    to improve its outcome,

    241

    00:16:46,739 --> 00:16:47,429
    the outcome.

    242

    00:16:48,340 --> 00:16:53,380
    I think what you're describing really is the future of pharmacogenomics.

    243

    00:16:53,390 --> 00:16:54,599
    Um In other words,

    244

    00:16:54,609 --> 00:17:03,419
    not singing out pharmacogenomics as you know the end all and be all in the treatment paradigm.

    245

    00:17:03,559 --> 00:17:08,040
    But using a PGX test in combination with,

    246

    00:17:08,050 --> 00:17:09,069
    like you mentioned,

    247

    00:17:09,250 --> 00:17:11,160
    other serological tests,

    248

    00:17:11,170 --> 00:17:12,959
    maybe other genetic tests.

    249

    00:17:13,290 --> 00:17:14,890
    Um But you know,

    250

    00:17:14,900 --> 00:17:25,869
    I think what we want our audience to really wrap their heads around is that PGX is just a piece of that larger puzzle um from diagnosis to treatment to,

    251

    00:17:25,880 --> 00:17:26,910
    to remission.

    252

    00:17:27,239 --> 00:17:29,880
    So I think you guys are absolutely,

    253

    00:17:29,890 --> 00:17:31,579
    you're already in the future.

    254

    00:17:31,589 --> 00:17:32,849
    In other words,

    255

    00:17:32,859 --> 00:17:33,130
    you know,

    256

    00:17:33,140 --> 00:17:39,689
    you're already providing all these different uh tests um like you mentioned to,

    257

    00:17:39,699 --> 00:17:44,310
    to facilitate from diagnosis to remission to remission.

    258

    00:17:44,660 --> 00:17:45,520
    That's correct.

    259

    00:17:45,530 --> 00:17:45,829
    Yeah.

    260

    00:17:46,349 --> 00:17:55,089
    So um you've given us so much great information about uh the tests that that you guys offer.

    261

    00:17:55,329 --> 00:18:02,060
    Can you explain to our audience um your newest test?

    262

    00:18:02,069 --> 00:18:03,859
    Uh the responder test.

    263

    00:18:04,150 --> 00:18:12,979
    And um what role it will play in the paradigm from the diagnosis of IBD to remission?

    264

    00:18:14,050 --> 00:18:14,260
    Yeah,

    265

    00:18:14,270 --> 00:18:14,760
    sure.

    266

    00:18:14,770 --> 00:18:15,569
    So we,

    267

    00:18:15,579 --> 00:18:18,069
    we are doing things a little bit different than other.

    268

    00:18:18,079 --> 00:18:19,489
    We do believe that uh you know,

    269

    00:18:19,500 --> 00:18:21,449
    the it has to be simple.

    270

    00:18:21,459 --> 00:18:24,189
    Uh uh We can obviously construct some very,

    271

    00:18:24,199 --> 00:18:33,530
    very complex algorithm and there are some tests that do that with a very sophisticated machine learning based tools that are available using neural networks,

    272

    00:18:33,540 --> 00:18:33,729
    you know,

    273

    00:18:33,739 --> 00:18:34,790
    those sorts of things.

    274

    00:18:34,800 --> 00:18:39,729
    But we have taken on a different approach where with the responder test,

    275

    00:18:39,739 --> 00:18:40,329
    we are basically,

    276

    00:18:40,339 --> 00:18:45,160
    we are taking an approach which is very simple to address the first and foremost.

    277

    00:18:45,170 --> 00:18:53,020
    Most important aspect of responding uh predicting response to uh to medication is the pharmacokinetics.

    278

    00:18:53,280 --> 00:19:03,250
    Uh You cannot be responding to a drug if the drug is not given and you obviously cannot respond to a drug if the drug is not metabolized adequately.

    279

    00:19:03,359 --> 00:19:06,349
    And this is what we are doing with the responder test.

    280

    00:19:06,579 --> 00:19:09,010
    We are addressing some uh uh you know,

    281

    00:19:09,020 --> 00:19:11,630
    fundamental issues with those uh biologist,

    282

    00:19:11,640 --> 00:19:12,410
    for example,

    283

    00:19:12,660 --> 00:19:15,170
    uh the anti tumor necrosis factors.

    284

    00:19:15,180 --> 00:19:15,650
    So,

    285

    00:19:15,750 --> 00:19:19,199
    such as uh Infliximab and Adalimumab,

    286

    00:19:19,209 --> 00:19:23,050
    it is well known uh that uh uh those drugs,

    287

    00:19:23,060 --> 00:19:25,689
    first of all are prone to immunization.

    288

    00:19:25,989 --> 00:19:36,949
    Uh Meaning that uh uh the drug itself uh is recognized by the immune system uh and digested by the antigen presenting cells.

    289

    00:19:36,959 --> 00:19:42,209
    If you will uh where you gonna have uh uh an immune uh uh response,

    290

    00:19:42,380 --> 00:19:56,979
    uh mounted a cancer drug to produce uh immunogen that will severely impact its pharmacokinetics where the labels will be inadequate to produce uh the desired uh anti-inflammatory effects.

    291

    00:19:56,989 --> 00:19:57,150
    So,

    292

    00:19:57,160 --> 00:19:58,890
    we are with the risk conductors,

    293

    00:19:58,900 --> 00:20:01,040
    we are combining two things together.

    294

    00:20:01,189 --> 00:20:07,959
    First of all is the genetic test itself which uh predicts the risk of immun immunization.

    295

    00:20:07,969 --> 00:20:18,010
    The name of the test is on HL A uh DQ A 105 ali uh that uh uh promotes the presentation of the,

    296

    00:20:18,020 --> 00:20:19,130
    of the,

    297

    00:20:19,140 --> 00:20:19,910
    of Infliximab,

    298

    00:20:20,010 --> 00:20:20,750
    for example,

    299

    00:20:20,760 --> 00:20:32,130
    to the T cell repertoire in order to uh promote the Ronon expansion and the formation of the anti antibodies together with uh another dimension which is the clearance,

    300

    00:20:32,140 --> 00:20:33,670
    which is as important.

    301

    00:20:33,949 --> 00:20:36,209
    Uh One of the key issue is the,

    302

    00:20:36,219 --> 00:20:36,770
    the,

    303

    00:20:36,780 --> 00:20:41,239
    the monoclonal antibodies and uh such as Infliximab or Adalimumab.

    304

    00:20:41,329 --> 00:20:42,280
    But in fact,

    305

    00:20:42,290 --> 00:20:45,890
    a neon antibodies that those drugs are uh you know,

    306

    00:20:45,900 --> 00:20:49,010
    cleared and consumed uh from the,

    307

    00:20:49,020 --> 00:20:50,949
    from the central compartment if you will,

    308

    00:20:50,959 --> 00:20:54,520
    since we are doing a little bit of uh uh pharmacokinetics here.

    309

    00:20:54,530 --> 00:20:56,020
    And uh uh you know,

    310

    00:20:56,030 --> 00:21:06,670
    if the patient present who is uh a high degree of inflammatory burden is gonna have uh the patient will have a high clearance and that's gonna worsen uh in the,

    311

    00:21:06,680 --> 00:21:13,939
    in the presence again of the HL AD Q A 105 genetic marker that uh associate with uh immunization.

    312

    00:21:13,949 --> 00:21:16,859
    So I but this is a combination of both,

    313

    00:21:17,199 --> 00:21:19,359
    these are the predictive factors of pharmacokinetic,

    314

    00:21:20,359 --> 00:21:38,209
    which we combine together where the patient presenting with a risk of immunization as well as accelerated clearance due to the fact that the patient has high inflammation or due to the fact that they are so intrinsic pharmacokinetic properties that makes that the patient,

    315

    00:21:38,219 --> 00:21:38,300
    you know,

    316

    00:21:38,310 --> 00:21:39,479
    will clear the drug very,

    317

    00:21:39,489 --> 00:21:40,260
    very fast.

    318

    00:21:40,560 --> 00:21:41,670
    For example,

    319

    00:21:41,680 --> 00:21:46,819
    due to the inefficient uh recirculation of the drug itself with the new,

    320

    00:21:46,869 --> 00:21:46,930
    the,

    321

    00:21:46,939 --> 00:21:50,599
    the the in the reticular on the system.

    322

    00:21:50,920 --> 00:21:51,619
    Together,

    323

    00:21:51,630 --> 00:22:02,109
    those patients presenting with uh uh together these uh poor prognostic factor of pharmacokinetic origin will tend to be severely underdose,

    324

    00:22:02,380 --> 00:22:06,719
    will not be responding to the drug uh adequately as and they,

    325

    00:22:06,729 --> 00:22:10,719
    and they probably should in the first place if you are able to address uh you know,

    326

    00:22:10,729 --> 00:22:12,270
    the the the exposure.

    327

    00:22:12,439 --> 00:22:14,079
    So what we do with this test,

    328

    00:22:14,089 --> 00:22:21,640
    we will be able to inform uh the clinic that the patient is at risk of achieving,

    329

    00:22:21,650 --> 00:22:30,829
    of achieving suboptimal pharmacokinetics and therefore being able to adjust the dose uh uh to start with more adequately.

    330

    00:22:30,839 --> 00:22:38,650
    So that the the the proper uh exposure is achieved uh during induction to again to,

    331

    00:22:38,660 --> 00:22:39,040
    to,

    332

    00:22:39,050 --> 00:22:39,380
    to,

    333

    00:22:39,390 --> 00:22:40,890
    to achieve a better outcome.

    334

    00:22:41,040 --> 00:22:47,270
    And I think the pharmacist will have a very important role to play here in terms of absolutely,

    335

    00:22:47,280 --> 00:22:51,239
    that information is priceless in the management of these medications.

    336

    00:22:51,250 --> 00:22:54,930
    So thanks for elaborating on that.

    337

    00:22:56,010 --> 00:22:59,040
    And if I may add in our previous conversation,

    338

    00:22:59,050 --> 00:23:00,810
    uh before the recording of podcast,

    339

    00:23:00,819 --> 00:23:08,869
    we had discussed um you guys' robust platform for collaborating with payers to obtain market access and reimbursements for the test.

    340

    00:23:09,109 --> 00:23:14,109
    But without stealing the Thunder from uh Prometheus market access and reimbursement team,

    341

    00:23:14,199 --> 00:23:22,619
    can you please uh briefly detail how Prometheus has proactively worked with payers to solve the problem.

    342

    00:23:22,920 --> 00:23:27,349
    Um the population health problem by building the evidence payers want,

    343

    00:23:27,359 --> 00:23:41,170
    want to see um about your test before you go to the market and then build the test and then hope the payers will see the value and the result and then that will improve the market access and reimbursement for your um precision medicine test.

    344

    00:23:42,160 --> 00:23:42,339
    Yeah.

    345

    00:23:42,349 --> 00:23:43,180
    So briefly I can,

    346

    00:23:43,189 --> 00:23:43,579
    I'm,

    347

    00:23:43,589 --> 00:23:46,619
    I'm probably not the right person to answer that question.

    348

    00:23:46,630 --> 00:23:47,369
    We have a very,

    349

    00:23:47,380 --> 00:23:52,400
    very efficient market access group uh uh pro meters that does a splendid job.

    350

    00:23:52,410 --> 00:23:59,780
    But uh uh uh what I can tell you that we have an evidence uh uh development plan in place where we,

    351

    00:23:59,790 --> 00:24:14,000
    we are establishing the clinical utility of our testing solution by demonstrating uh the payer value uh with respect of uh patient management and uh uh and the,

    352

    00:24:14,010 --> 00:24:16,630
    and the impact of our technology on the,

    353

    00:24:16,640 --> 00:24:18,119
    on physician behavior.

    354

    00:24:18,430 --> 00:24:21,319
    Uh We have uh uh already uh you know,

    355

    00:24:21,329 --> 00:24:25,160
    commercialized uh two of those tests for which we have initiated,

    356

    00:24:25,170 --> 00:24:29,040
    initiated the Power studies uh that uh uh you know,

    357

    00:24:29,050 --> 00:24:32,000
    already provide uh you know,

    358

    00:24:32,104 --> 00:24:34,484
    differentiated and the value to,

    359

    00:24:34,494 --> 00:24:35,915
    to the payer where we are,

    360

    00:24:35,925 --> 00:24:36,025
    the,

    361

    00:24:36,035 --> 00:24:46,005
    the clinicians are basically using our technology to make treatment decision uh as well as uh some prospective clinicality study which we are initiating,

    362

    00:24:46,145 --> 00:24:47,555
    initiating to.

    363

    00:24:47,564 --> 00:24:48,574
    Um uh again,

    364

    00:24:48,584 --> 00:24:49,425
    demonstrate the,

    365

    00:24:49,435 --> 00:24:49,915
    the,

    366

    00:24:49,925 --> 00:24:50,244
    the,

    367

    00:24:50,255 --> 00:24:53,594
    the payer value you uh uh we can certainly follow up with,

    368

    00:24:53,604 --> 00:24:58,755
    uh you can certainly follow up with our market access group uh uh as appropriate there.

    369

    00:24:58,765 --> 00:25:00,765
    Uh They can fill you with more information.

    370

    00:25:01,349 --> 00:25:01,589
    No,

    371

    00:25:01,599 --> 00:25:02,520
    that totally makes sense.

    372

    00:25:02,530 --> 00:25:03,310
    That totally makes sense.

    373

    00:25:03,319 --> 00:25:10,890
    But um we're excited that you're also farm d So how did you get to this role of outside the box path?

    374

    00:25:10,900 --> 00:25:11,550
    There?

    375

    00:25:11,640 --> 00:25:17,530
    There may be a pharmacist student or pharmacist wanting to switch or transition into a role such as yours,

    376

    00:25:17,540 --> 00:25:19,609
    which is a Chief Scientific Officer.

    377

    00:25:19,619 --> 00:25:20,609
    I want to learn more.

    378

    00:25:20,619 --> 00:25:23,920
    So how would you um can you talk a little bit about that?

    379

    00:25:24,560 --> 00:25:24,780
    Well,

    380

    00:25:24,790 --> 00:25:26,270
    we are clinical laboratories.

    381

    00:25:26,280 --> 00:25:29,400
    So in order to uh uh to be in my role,

    382

    00:25:29,410 --> 00:25:34,020
    you need to have uh uh you need to have expertise in clinical laboratory science.

    383

    00:25:34,030 --> 00:25:36,140
    So for the students is basically,

    384

    00:25:36,150 --> 00:25:36,300
    you know,

    385

    00:25:36,310 --> 00:25:40,770
    to do the family degree and then complete the family degree with uh a doctorate,

    386

    00:25:40,780 --> 00:25:40,930
    you know,

    387

    00:25:40,939 --> 00:25:44,260
    which is uh focus on clinical laboratory science.

    388

    00:25:44,270 --> 00:25:46,079
    So you can achieve uh uh you know,

    389

    00:25:46,089 --> 00:25:47,640
    the all the elements you need to be,

    390

    00:25:47,650 --> 00:25:48,219
    for example,

    391

    00:25:48,229 --> 00:25:53,189
    board certified uh as uh as as medical laboratory director.

    392

    00:25:53,199 --> 00:25:55,160
    So you can uh uh so,

    393

    00:25:55,170 --> 00:25:55,589
    uh yeah,

    394

    00:25:55,599 --> 00:25:56,030
    this is,

    395

    00:25:56,040 --> 00:25:56,400
    this is,

    396

    00:25:56,410 --> 00:25:57,209
    this is uh you know,

    397

    00:25:57,219 --> 00:25:59,160
    a great opportunity I think for pharmacies,

    398

    00:25:59,170 --> 00:26:10,800
    there is an absolute need to uh have the clinical pharmacist provide uh uh drug information to healthcare professional as well as uh assist patient with the monitoring of their disease,

    399

    00:26:10,810 --> 00:26:15,229
    the effectiveness of the therapy and um and uh you know,

    400

    00:26:15,239 --> 00:26:16,060
    monitoring the,

    401

    00:26:16,069 --> 00:26:20,969
    the side effect and the toxicity from uh from those uh those medication.

    402

    00:26:24,650 --> 00:26:24,959
    Well,

    403

    00:26:24,969 --> 00:26:32,119
    the I know our audience is going to have uh additional questions for you.

    404

    00:26:32,130 --> 00:26:32,540
    I mean,

    405

    00:26:32,989 --> 00:26:35,609
    you've provided them with so much great information,

    406

    00:26:35,619 --> 00:26:44,959
    but it's only the beginning of what they could possibly learn um about um the testing that you do for IBD and,

    407

    00:26:44,969 --> 00:26:46,729
    and even your career path.

    408

    00:26:47,050 --> 00:26:47,530
    So,

    409

    00:26:47,540 --> 00:26:49,300
    if you wouldn't mind telling us,

    410

    00:26:49,310 --> 00:26:51,359
    um because we have to wrap up,

    411

    00:26:51,369 --> 00:26:52,670
    unfortunately,

    412

    00:26:53,150 --> 00:26:55,810
    this episode of the podcast,

    413

    00:26:55,819 --> 00:27:00,250
    uh could you tell us how our audience members might be able to contact you directly.

    414

    00:27:01,260 --> 00:27:01,449
    Yeah,

    415

    00:27:01,459 --> 00:27:07,079
    I can be contacted on my uh on my email at TT W at como slab dot com.

    416

    00:27:07,949 --> 00:27:08,810
    All right.

    417

    00:27:09,069 --> 00:27:09,300
    Well,

    418

    00:27:09,310 --> 00:27:14,290
    thank you again so much uh for joining us on this episode.

    419

    00:27:14,300 --> 00:27:15,290
    We really,

    420

    00:27:15,300 --> 00:27:29,530
    really hope that our listeners um ideas of not only what PGX can be but how PGX can be utilized in a comprehensive testing suite.

    421

    00:27:29,709 --> 00:27:35,670
    We really hope that our a our audience will um listen in and learn this information.

    422

    00:27:36,280 --> 00:27:37,869
    Um And to our audience,

    423

    00:27:37,880 --> 00:27:39,439
    thank you for tuning in.

    424

    00:27:39,449 --> 00:27:42,619
    We really hope that you've learned from this episode.

    425

    00:27:43,130 --> 00:27:46,339
    Uh We do a whole lot of PG Xing here on this podcast.

    426

    00:27:46,349 --> 00:27:48,380
    We talk about PGX Science,

    427

    00:27:48,390 --> 00:27:52,030
    clinical application and the business of PGX.

    428

    00:27:52,260 --> 00:27:54,880
    So we'd love to hear about from you.

    429

    00:27:55,099 --> 00:27:56,479
    I love to hear from you.

    430

    00:27:56,489 --> 00:27:58,439
    Um What can we teach you?

    431

    00:27:58,449 --> 00:28:00,920
    What more can we teach you through our podcast?

    432

    00:28:00,930 --> 00:28:12,349
    So please drop us a message on linkedin and let us know and please share this link to this podcast link episode with everyone so they can tune in and listen to the PGX for promises podcast.

    433

    00:28:12,520 --> 00:28:15,369
    Leave us a review on Apple podcast or Spotify.

    434

    00:28:15,459 --> 00:28:18,130
    And you can also visit us on PGX four,

    435

    00:28:18,140 --> 00:28:22,989
    the number four Rx dot com to listen to all our other episodes.

    436

    00:28:23,000 --> 00:28:23,079
    Well,

    437

    00:28:23,089 --> 00:28:23,790
    thank you.

    438

    00:28:24,199 --> 00:28:28,750
    Thanks for your interest in PGX and for spending some time with us.

    439

    00:28:28,760 --> 00:28:35,670
    Please share this podcast and leave us a review on Apple podcasts or Spotify for all of our episodes.

    440

    00:28:35,680 --> 00:28:39,390
    Please visit PGX four Rx dot com.

    441

    00:28:39,569 --> 00:28:43,380
    That's PGX four Rx dot com.

     

    29 min
  • The Extra Dose: User Conference Post-Show Part One | Framework Focus

    This is part one of the three-part FrameworkLTC User Conference Post-Show series. This series is hosted by the Pharmacy Podcast Network’s own Todd Eury. In this series, Todd chats with SoftWriters’ team members, exhibitors, partners, and conference attendees live from the show floor. This episode features Mark Fulton, Cara Whipple, Dan Kennedy, Karen Sims, and Derek Taylor. 

    30 min

About Pharmacy Podcast Network

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Pharmacy Podcast Network (PPN) is the world’s largest network of podcasts dedicated to the pharmacy professional and industry insiders. Our content is about dynamic people in the pharmacy industry making a difference and delivering the best pharmacy care. We have over 40+ podcasts with thousands of interviews. 

Pharmacists are the cornerstone of healthcare, and the PPN reflects that. From Community, LTC, Specialty Pharmacy to Drug Development, Government policy and DigitalHealth, we cover it all. Partner with us to connect with thousands of daily listeners and find the right pharmacist across various specialties and topics, ensuring your products and services resonate where it matters most. We build strong audio brands through Pharmacists who see patients almost 9x more than primary care.

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