Pharmacy Podcast Network

• First-hand experience with allergies as a chronic condition and advocating for the consumer 

Controlled substances, including opioids, benzodiazepines, and medical cannabis, are commonly prescribed for the treatment of chronic pain. Urine drug screens (UDS) are often used in clinical practice to test for the presence of prescribed drugs to monitor compliance. Understanding how to appropriately interpret the results of urine drug screening is critical to providing effective patient care and maintaining patient trust. Pharmacists in various practice settings can play important roles in urine drug screenings.

The goal of this podcast is to provide pharmacists and other clinicians with insight and information for appropriately interpreting urine drug screening results. The conversation will focus on the types of drug screening panels, possible causes of false- positives and negatives, and how metabolism of drugs can impact urine drug screening results. Tips on how to effectively have conversations with patients that can be difficult will also be part of the discussion.

Click Therapeutics develops prescription software applications as medical devices that work independently or in conjunction with pharmacotherapies to treat disease. Click clinically validates these applications through rigorous randomized, controlled trials to demonstrate safety and efficacy.

Join us for a special guest interview this week with molecular plant scientist George Sellhorn, on a wide ranging interview around psilocybin and functional mushroom testing

George Sellhorn Ph.D, is the founder, owner and Principal Scientist of Flourish Labs in Portland Oregon and earned his Ph.D. in Molecular Plant Sciences from Washington State University (2006) and his B.S. in Biology from Indiana University (1999). George has worked in both academia and the biotechnology industries from 2006-2021 working on projects such as HIV vaccine development, production, characterization and pre-clinical evaluation as well as bioconjugate-based therapeutics including pegylated interferon for multiple sclerosis, bifunctional antibodies and antibody drug conjugates for breast cancer and poly(carboxybetaine) L-asparaginase bioconjugates for acute lymphoblastic leukemia.

George has 23 years of extensive experience with liquid chromatography using both High-Performance Liquid Chromatography (HPLC) and Fast protein liquid chromatography (FPLC) and these techniques are one of his primary expertise. Some of the leadership roles he has held in the laboratory include Senior Scientist, Laboratory Director and Principal Investigator. George has also worked in the medical and recreational Cannabis industries from 2009-2021 which included cultivation, processing and consulting in Washington, Oregon and Colorado. Flourish Labs, LLC was founded in August 2021 and opened its services to customers on January 1st , 2022.

Link to George’s business here at Flourish Labs (OR):

https://flourishlabsoregon.com/

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Glossary of terms

APE—Albino Penis Envy, considered one of the most potent strains of psilocybin cubensis in terms

4-ACO: Or O-acetylpsilocybin or 4-Aco-DMT: semi synthetic derivatives of psilocybin often used in pharmacologic studies

BOL or 2-Br-LSD. Non hallucinogenic LSD derivative synthesized by Albert Hofman (who also synthesized LSD).

CLIA and CAP: College of American pathologists and Clinical Laboratory Improvement Amendments—regulatory bodies for clinical laboratories.

COA-certificate of analysis, offered by third party product testing labs.

CRM: Certified Reference Materials (not Customer Relationship Management in this context)

Entourage effect: hypothesis that compounds in cannabis other than CBD and THC act in synergy to exhibit pharmacologic effect (pretty good evidence to support this).

GPCR: G protein coupled receptor: largest family of membrane proteins

LOQ—Limit of quantification LOD—Level of detection. Level of detection is smallest concentration of a sample that can be consistently analyzed with 95% probability, LOQ is smallest concentration that can be measured with less than 10 to 20% variation.

PSK (Krestin): Also known as Polysaccharide K, derived from Coriolus versicolor mushroom, widely used as folk remedy and adjuvant therapy for cancer treatment in some cultures.

Terpenoids: Broad class of naturally occurring 5 Carbon molecules that show wide range of pharmacologic activities.

5-ME-O-DMT: Psychoactive drug derived from toad venom of glands of the Sonoran Desert toad (lots more to come on this).

Today's episode focuses on one pharmacists determination to push forward onto to phase II after not matching in phase I. Listen to hear her amazing story of resilience

Claudia Fox, MD, MPH, is a pediatrician and weight management specialist who specializes in pediatric preventive cardiology and family weight management. She sees patients at University of Minnesota Health Masonic Children's Hospital Pediatric Specialty Care Discovery Clinic, University of Minnesota Health Maple Grove Clinics and the Specialty Clinic for Children in Burnsville. Dr. Fox is also an associate professor as well as fellowship program director and faculty member in the Division of Pediatric Gastroenterology Hepatology and Nutrition in the Department of Pediatrics at the University of Minnesota Medical School.

AJ Asgari, the CEO of Drugstore2Door, joined the Sports Pharmacy Podcast for a second round of discussion. We talked about their fitness journeys.  AJ shared his background, growing up in Oklahoma and initially planning to become a doctor before pivoting to pharmacy. He became an entrepreneur and currently owns nine pharmacies. AJ founded Drugstore2Door to address the challenges faced by independent pharmacies. The platform aims to digitize the entire pharmacy experience and provide a seamless online presence. They offer personalized website design, e-commerce capabilities, and services to help pharmacies generate additional revenue outside of PBMs. AJ emphasized the importance of customer feedback and continuous improvement in refining their product. Drugstore2Door's goal is to get as many independent pharmacies online as possible, allowing customers to access and pay for various pharmacy services. The platform covers prescription services, e-commerce, and other offerings, providing a turnkey solution for pharmacies. They are constantly developing new features and enhancements to make the integration seamless and user-friendly for pharmacies.