Pharmaversity®

Sterility is the most critical parameter in ready-to-use packaging. As it depends not only on efficient processes but also on the involved packaging materials, choosing the appropriate sterilization technique is crucial to assure safe packaging components. Furthermore, sterile integrity of the primary packaging components has to be maintained during introduction and processing in an aseptic fill + finish environment. In this webcast, the audience will learn about typically used sterilization technologies, the underlying processes and understand which risks and benefits are associated with them.

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Sterile injectable drugs play a crucial role in the treatment of disease. All stakeholders in this industry have the inherent goal to make injectable drugs safe and effective. This includes an expectation that every lot be essentially free from visible particulates, and that manufacturers strive to minimize all particulate and foreign contamination. In this Webinar, we reveal how we reduce particles in ready-to-use packaging by aligning lid material, adhesive and sealing parameters based on a scientific study performed in 2019.

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With more and more drugs shifting to a homecare setting, drug delivery devices and wearables are getting increasingly important. To ensure that pharmaceutical packaging meets the specific requirements of these devices, including functionality and ease-of-use, SCHOTT offers to co-create individualized containers made out of cyclic olefin copolymer (COC) with its customers. With SCHOTT TOPPAC® unique, the customer is given the opportunity to co-develop a container around his existing device and not vice versa. So depending on the specific needs – for example, drug stability, fill & finish needs or compatibility – a novel primary container can be created without compromising on the device design. A defined 4-step sampling process reduces cost and overall project risk while allowing for reduced time-to-market.

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Intravenous medications are a pivotal drug class that are used in many critical hospital treatments, for example on ICUs or in Operation Rooms. In these surroundings, the risk for medical errors, such as giving the wrong drug or the wrong dose can create a life-threatening situation for the patient. Especially in emergencies, the drug administration often has to be done very fast and, thus, time-consuming multi-step preparation by health care professionals need to be minimized. Pre-filled containers, and here particularly pre-filled syringes, are a highly preferred solution by the hospital staff to avoid exactly these kind of errors that could risk the patient’s lives. This session will evaluate what makes a high-quality COC pre-filled syringe being an easy-to-use-solution, outlining not only the advantages of COC as a material, but also discuss the compatibility with key hospital devices, such as syringe pumps and needless connectors and additional innovative solutions like tamper evidence. The session will also show how the general trend in the field of compounding to switch to high-quality pre-filled containers improves the overall drug shelf life, ease of use for nurses and physicians as well as the overall patient safety for various medications in this field.

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Protecting medication from undesired interactions with the surrounding environment and preserving their efficacy during shelf life is one of the most pressing challenges for the pharmaceutical industry. Specially developed inner coating solutions, such as SCHOTT TopLyo® and SCHOTT Type I plus® may fit to the specific needs in your drug development cycle. These functional coatings applied to the inner surface of a pharmaceutical container make it more suitable for biologics and all other highly sensitive drugs.

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COVID-19 has brought the mRNA era into existence. Biotechs that have been working on the technology for years are now ready for liftoff, with vaccines and therapeutics for a range of diseases from flu to cystic fibrosis.  But the technology comes with storage and transport limitations driven by the fragility of the lipid nanoparticles (LNPs) that function as mRNA delivery systems.  Deep cold temperature conditions and consecutive, unpredictable free-thaw cycles may impact the functional performance, mechanical stability, container closure integrity, sterility and particulate levels of the drug container.  These risks raise important questions about the safety of different primary packaging formats, and must be fully understood to launch mRNA drugs with confidence.
In this session, we will discuss test data for syriQ® glass syringes, demonstrating robust performance down to -50°C and highlighting the importance of complex component and materials interaction in the pre-filled syringe system.  Our results confirm the suitability of syriQ® glass pre-filled syringes as a primary packaging solution for mRNA and other applications requiring cold storage down to -50°C.  This allows drug manufacturers to exploit the benefits that come with glass of established manufacturing networks, multiple supply sources, and a clear regulatory path.

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adaptiQ® offers proven SCHOTT vials in a modularized ready-to-use configuration. This session will focus on how our new packaging options can help you to increase manufacturing flexibility and improving TCO. All while ensuring patient safety.

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Glass is a strong material, but it can be sensitive if handled inadequately. SmartSkin’s Quantifeel pressure-sensing drones and SCHOTT’s glass analytics are powerful tools for identifying, localizing and verifying the root causes of breakage – helping to prevent unnecessary downtime and contributing to line optimization.

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According to an evaluation of the WHO, medication errors cause at least one death every day and injure approximately 1.3 million people annually in the US alone.  Apart from harming patients, medication errors also drive up the costs for the health care system. Adverse drug events in US community hospitals cost more than 3,000 USD per incident on average and lead to a median increase of hospital length of stay of 3.1 days. On the other hand, drug shortages may adversely affect patient care by compromising or delaying medical procedures. High quality pre-filled syringes make the drug administration process much faster, easier and safer.

In this joint session with AST, leader in aseptic manufacturing processes, we will break down the daunting challenge of selecting the right pre-fillable syringe and how to process it on an automated, high speed filling line, contributing thus to reduce drug shortages and save costs for hospitals and the health care system.

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Efficiency and flexibility is key in pharmaceutical fill & finish settings. Especially when facing smaller batch sizes. In these environments quick change overs from one drug to another are of utmost importance. But what if the transition does not only cover various drug types, but also require filling of various container types? Be invited to the Groninger Showroom in Crailsheim where Marius Römer (Groninger co GmbH) and Christian Arends (SCHOTT Pharmaceutical systems) demonstrate format part changeovers in real time and explain how flexible filling machines in combination with RTU containers can improve your fill and finish processes.

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