Piloting Health

We've talked a lot about the opportunities and possibilities of how regenerative therapies can work, so today I wanted to get into the nuts and bolts how it all works.

In this episode, we'll be discussing:

➡️ Inflammation and how it causes both functional repair and dysfunctional repair.

➡️ Regenerative therapies for osteoarthritis, irritable bowel syndrome and colitis.

➡️ How a small population of people immune to HIV may be the secret to completely curing it.

➡️ Chimeric cells and their role in treating disease. 

➡️ Why the medical field has one of the largest data pools for study, and how we can use AI to compile this data and accelerate therapies.

And, of course, I kick off the episode associating the lessons I've learned as a pilot with lessons that can be learned in healthcare.  This is Piloting Health.

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The type of stem cell matters. There's no question that cells taken from the blood of the placenta or umbilical cord immediately after a pregnancy are going to have the greatest capacity for therapeutic use. The therapeutic use of mesenchymal stem cells does diminish with age. 

In this brief, but important, episode, I want to talk about why banking stem cells could have a profound impact on health and longevity later in life.  And while adults can bank stem cells, possibly the biggest opportunity is for parents to bank the stem cells of their newborn immediately after birth. This procedure, as I've often stated, can be done very safely and very ethically through the extraction of stem cells of the placenta, which is typically discarded anyway. 

These cells can act as a master boot disc that could be used to re-install healthy cells in the case of certain types of diseases your child gets much later in life. 

So whether you're planning on having children some day, or are just excited about the incredible possibilities of stem cell therapy, this is a quick listen you won't want to miss.

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Last week, I talked about the four pillars of healthy aging.  Last on the list - but definitely not least - was youthful aesthetics. Stem cells can have a tremendous impact on the health of our skin.  We're seeing it with regard to the treatment of burns. In fact, my company, Celularity, has a product that utilizes stem cells for the treatment of burns.  We're also seeing more and more skin care companies use stem cells for everyday products and therapies. 

The health of our skin - the body's largest organ - is an important part of our overall health and our lifespan. In this episode, I'll look at how stem cells can be used to heal skin damage and help us maintain our youthful aesthetics.

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I often talk about what I consider to be the four pillars of health aging:

➡️ High Performance Mobility

➡️ High Performance Cognitive Function

➡️ High Performance Immune Function

➡️ Youthful Aesthetics

In this episode, I dive deep into how stem cells can help in each of these four pillars by connecting the dots on stem cell research and application.

I believe we're on the verge of massive breakthroughs in stem cell therapies - therapies that will have a significant impact on each of the pillars above, and our lifespan. Indeed, they already are, and I believe what we're seeing with placental stem cells will continue to play a major roll. In fact, if you haven't watched or listened to the episode with Mary Webb and her son, Quentin, a few weeks back, I'd invite you to listen.  Quentin was one of the first recipients of stem cell therapy derived from the placenta - his sisters - after a leukemia diagnosis 17 years ago. It was great to talk to him and Mary, who are both doing great!

If you're curious about how stem cells could be used to improve lifespan, and what they could potentially mean for your long-term health, this is the episode for you. Let's connect the dots on all the different stem cell information and talk about the pillars of healthy aging.  Welcome aboard Piloting Health.

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For this episode, I decided to have a little fun and see what the most asked questions on Google searches were about stem cells.  As the placenta is my world, I also looked up some of the questions people are Google searching about placental stem cells.

What people are searching for is pretty interesting.  Questions ranged from aging to the legalities - and even hair loss.  If you're curious about stem cells at all, and what they may be capable of, this is the episode for you.

In this episode, I'll answer:

➡️ Do stem cells grow back?

➡️ How are placental stem cells collected?

➡️ Do stem cells have DNA?

➡️ Why are stem cells banned in the USA? (They're not, but I explain why people ask.)

➡️ Do stem cells help with hair loss?

➡️ Do stem cells cause cancer?

➡️ Do stem cell supplements really work?

And more!

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This was a particularly personal episode for me. My guests are Mary Webb and her son, Quentin Murray.  Quentin - diagnosed 17 years ago with Leukemia - was one of the first recipients of cell therapy derived from the placenta.  I got to know to know Quentin during this treatment, as well as his mother, Mary Webb, who tenaciously explored options for treatment for Quentin.

As it just so happened, Mary was pregnant with Quentin's sister at the time. Using stem cells from his sister's placenta - which is typically just destroyed after birth - we were able to administer therapies which restored the function of his bone marrow, and enhanced the anti-tumor effect that his immune cells could provide. 

I've stayed in touch with the family since then and today, Quentin is doing great.  He's going to school, giving back to the community and enjoying life.  In this episode, Quentin and Mary join us to talk about their experience.  

This is the human side of medical advancements.  This is what we do it for. Enjoy the episode.

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We may not be far off from the end of hip and knee replacements, at least if this week's guest has anything to say about it. Nina Tandon is the co-founder and CEO of EpiBone, a biotech company that grows bone and cartilage for skeletal reconstruction. Under her leaderhip, EpiBone has raised millions in investor funding and conducted the first human implantations of bones grown from stem cells.  

In this episode, Nina talks about the process of growing bones from stem cells, and the importance of bone and cartilage repair BEFORE they've deteriorated.  The regenerative approach to this process is fascinating.

This was an insightful discussion, and in addition to biotech advancements, we dug into the challenges startups in this space face, why New Jersey is seeing so many startups in biotech, and the importance of exposing more young women to STEM (science, technology, engineering & math) studies at a young age. 

Talking with people like Nina keep me inspired about the future of medicine, biotechnology and human longevity.  I hope you enjoy the episode.

Follow Dr. Bob Hariri on his platforms here:

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Why are we so far away from finding a cure for different types of cancer? Do tests run on mice have any relevance to the efficacy on people? Is the medical community getting it all wrong and where has cancer treatment failed the patient?

My guest today is Dr. Azra Raza, the Chan Soon Professor of Medicine and Clinical Director of the Edward P. Evans Foundation MDS Center at Columbia University in New York.  She is a practicing oncologist, seeing 30-40 cancer patients weekly, and has dedicated her life to the prevention of all chronic diseases, including cancer, through early detection. Her latest book, "THE FIRST CELL: And the Human Costs of Pursuing Cancer to the Last" is a national bestseller and has been translated into nine languages. 

In this episode, she speaks to some of the inefficiencies the medical community creates in the treatment and fight against cancer, the human cost of cancer treatment and even dives into the connection between medicine and poetry.  This was an incredibly fun, informative, and intense discussion and I know you're going to enjoy it and learn a lot.

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Let's explore aging, and what some of the advances in the delay - and someday even reversal - of aging could entail.  It's interesting, but the biology of aging mirrors the biology of cancer.  As we learn more about the advances in the prevention, delay or reversal of cancer, we are - in effect - learning about about these same things in aging.  It's possible stem cells could hold the secret.

In this episode, we'll discuss:

➡️ How the body is like a computer, and why stem cells can "reboot" your system with a perfect copy of our biological software.

➡️ Why cancer in pregnant mothers doesn't spread to the fetus.

➡️ The hallmarks of healthy aging.

➡️ The importance of preserving muscle tissue and how it affects the way we age.

➡️ And more!

Follow Dr. Bob Hariri on his platforms here:

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Every day, hospitals are literally throwing away a treasure trove of natural resources that have potential life-saving possibilities.  I'm talking about the placenta, and the placental stem cells contained within. 

What makes placental stem cells unique? In this important episode, I talk about:

➡️ Therapeutic and commercial opportunities that placental stem cells provide.

➡️ The adaptive nature of the placenta, and why a woman's body doesn't reject a fetus in the case of surrogate pregnancies - or even natural pregnancies when you consider half of the DNA of the fetus is not from the mother.

➡️ What makes placental stem cell therapies more accessible than organ transplants.

➡️ What this all potentially means for your long-term health and wellness.

Follow Dr. Bob Hariri on his platforms here:

Web: www.pilotinghealth.com
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TikTok: https://www.tiktok.com/@pilotinghealth
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