Alex Calder investigates the devastating 1918 influenza pandemic that killed 50-100 million people worldwide yet was largely forgotten until our recent COVID-19 experience revived interest. The episode explores how this unusually deadly strain targeted healthy young adults through cytokine storms while spreading rapidly through wartime troop movements. Alex reveals how the pandemic's catastrophic death toll catalyzed the development of socialized healthcare systems, accelerated nursing professionalization, transformed hospital design, advanced virology research, and established modern public health institutions including predecessors to the CDC and WHO. Through striking parallels between 1918 responses and COVID-19 measures—from mask mandates to social distancing debates—the episode examines how this "forgotten pandemic" quietly revolutionized modern medicine while demonstrating the cyclical nature of society's relationship with infectious disease threats.

This content was created in partnership and with the help of Artificial Intelligence AI

Alex Calder examines how smallpox functioned as an unintentional biological weapon that facilitated European colonization of the Americas by killing up to 95% of indigenous populations who lacked immunity. The episode traces how this catastrophic demographic collapse created power vacuums that allowed small groups of European colonizers to establish footholds against previously mighty civilizations while reshaping environments through ecological changes. Alex explores the development of variolation practices across cultures before examining Edward Jenner's cowpox experiments that led to vaccination—humanity's first intentional victory against a deadly disease. The story culminates with smallpox becoming the only human disease ever deliberately eradicated through global cooperation, showing how this virus both enabled imperial conquests through uneven immunity and ultimately inspired one of medicine's greatest achievements.

This content was created in partnership and with the help of Artificial Intelligence AI

Alex Calder explores how the bubonic plague pandemic of the 14th century transformed European society by killing 30-60% of the population in just four years. The episode reveals how this demographic catastrophe created a labor shortage that gave surviving peasants unprecedented economic leverage, undermining feudalism's rigid social hierarchy. Alex examines how the Catholic Church's failure to explain or prevent the pandemic weakened religious authority, while the trauma of mass death reshaped artistic expression, urban planning, and attitudes toward mortality. Drawing connections to our experiences with COVID-19, the episode demonstrates how this medieval catastrophe accelerated technological innovation, educational reform, and social mobility while revealing both medieval society's fragility and its surprising adaptability in the face of biological disaster.












This content was created in partnership and with the help of Artificial Intelligence AI