1.The 1st line agent for an exsanguinating patient is and always will be blood.   2.There may be circumstances in which MSFP needs to be adjusted in order to compensate for changes we cause through the process of intubation and PPV.   3. The only reason we have literature showing pressors associated with an increase in mortality in trauma is because this intervention is performed on a daily basis in emergency departments and operating rooms. We need a well designed study that reports dosing regimens, a control arm, and patients randomly allocated.    https://www.foamfrat.com/single-post/2019/09/19/If-I-Taught-Hemodynamics-Response-To-EricNaysayerBauer