A Changi prisoner of war. A fridge full of urine. A handful of dead guinea pigs. And one of the most important medical breakthroughs of the 20th century.

Greg de Moore, Associate Professor of Psychiatry based at Sydney's Westmead Hospital, tells Marc Fennell (Stuff The British Stole) about the story of Australian doctor John Cade and his pioneering work in bipolar treatment. 

From the horrors of a Changi prison camp to a backyard shed experiment with lithium, this is the story of how science, serendipity, and sheer human determination transformed modern psychiatry.

Binge all the episodes of No One Saw It Coming now on the ABC listen app (Australia) or wherever you get your podcasts.

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