In this episode, Dr. Stanford, Lucy Janoyan, and Taylor Cu reflect on key takeaways from the Precision Medicine World Conference — from AI’s role in understanding disease to the future of polygenic risk scores. They discuss the challenges of data validity, patient privacy, and the evolving role of patients and providers in a tech-driven healthcare landscape, including a highlight from NVIDIA CEO Jensen Huang on how AI is set to reshape the future of medicine.

Takeaways

The conversation around precision medicine has evolved significantly since 2019.

AI is transforming patient care and the practice of medicine.

The PMWC provided a more intimate setting for meaningful discussions.

There is a growing concern about the ethical implications of AI in healthcare.

The transition from research to clinical practice is crucial for precision medicine.

Economic factors play a significant role in the adoption of precision medicine.

Digital twins could revolutionize personalized healthcare.

Data privacy and patient ownership are critical issues in genomic sequencing.

The insurance industry faces challenges in adapting to precision medicine.

The future of healthcare will be dramatically different in the next decade.

Chapters

00:00 Introduction to Precision Medicine and Conference Insights

05:22 Evolution of Precision Medicine Discussions

08:30 AI's Role in Healthcare Transformation

11:35 Challenges in Data Validity and Clinical Adoption

14:17 The Future of Polygenic Risk Scores

17:27 Optimism vs. Pessimism in Precision Medicine

20:26 Insurance and Healthcare Delivery Paradigms

23:31 Digital Twins and Their Impact on Precision Medicine

41:44 The Future of AI in Medicine

44:56 Understanding Aging and Disease Pathways

46:54 The Role of AI in Autonomous Science

48:40 Holistic and Precision Medicine

52:49 Data Privacy and Patient Governance

56:55 Concerns Over Genome Sequencing

01:02:13 The Global Landscape of Genomic Data

01:05:42 The Democratization of Precision Medicine

01:43:32 Introduction to Precision Medicine

01:43:32 The Importance of Personalized Health

Dr. William Stanford MD PHD FACP

[email protected]

Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.

A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field.

Sponsored by: Biography Health

This episode is sponsored by Biography Health — where DNA-powered healthcare is designed just for you. Biography Health is a HIPAA-compliant precision medicine platform that equips providers with AI-driven recommendations powered by your genetics, health history, and clinical insights — all while keeping data private, secure, and independent from large EHR systems.

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

Podcast Suggestion Survey

When Genes Collide: A Rare Diagnosis Reveals Complex Health Interactions with Dr. Philip Bretsky

For this episode, Dr. Bretsky shares a remarkable case study that unravels the complex relationship between genes and inflammation. When a patient's mysterious symptoms led to the rare diagnosis of VEXAS syndrome, it revealed an unexpected connection with cardiovascular health, demonstrating how different genetic factors can interact to amplify health risks.

Timestamps:

• 3:50 - Introduction to Lp(a) and its role in cardiovascular health
• 10:09 - Patient's initial presentation with testicular swelling
• 17:55 - Discussion of environmental factors and genetic mutations
• 23:28 - Understanding inflammation's role in cardiovascular risk
• 35:32 - Treatment decisions and stent placement
• 41:51 - Prevention strategies for inflammatory conditions
• 1:24:19 - Episode wrap-up and closing

Dr. Philip Bretsky's Contact Information:

Philip M. Bretsky MD PhD MPH FACP

1301 20th Street, Suite 230

Santa Monica, CA 90404

TEL: 310.828.4411

FAX: 310.828.2411

Facebook:@santamonicaprimarycare

Twitter / X: @santa_care

Instagram: @santa_monica_primary_care

Web:  www.drbretsky.com & www.santamonicaprimarycare.com

My monthly newsletter: https://lp.constantcontactpages.com/su/JtF9zzR

Dr. William Stanford MD PHD FACP

Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.

A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field.

Sponsored by: Biography Health

Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.

Other Resources Mentioned:

https://www.cnn.com/2023/01/24/health/vexas-syndrome-prevalence-study-wellness/index.html

https://www.amazon.com/Implementation-Personalized-Precision-Medicine-Prevention/dp/0323988083

Beauty Span and Health Span: Where Aesthetics Meets Longevity with Dr. Cory Goldberg

For this episode, we dive deep into the intersection of aesthetics and longevity with Dr. Cory Goldberg, a renowned plastic and craniofacial surgeon. Dr. Goldberg bridges the art of aesthetic medicine with the science of precision medicine, sharing groundbreaking insights on how oxidative stress affects both beauty and overall health, and discussing innovative approaches to extending both beauty span and health span.

Timestamps:

03:27:24 - Dr. Goldberg shares his background and journey from physiology to plastic surgery to precision medicine

23:31:24 - Deep discussion on senescent cells (zombie cells) and their impact on aging and health

35:13:13 - Exploration of the gut-skin-brain axis and microbiome connections

43:51:24 - Detailed explanation of reactive oxygen species (ROS) and their role in aging

57:46:07 - Discussion of GliSODin supplement and superoxide dismutase

1:18:52:13 - Dr. Goldberg's insights on diet, plant-based eating, and oxidative stress

1:27:27:15 - Overview of Dr. Goldberg's practice evolution and his vision for integrating longevity medicine with aesthetic medicine

Dr. Cory Goldberg

https://www.linkedin.com/in/corygoldbergmd/

https://www.corygoldbergmd.com/

https://www.instagram.com/drcorygoldbergmd/

Dr. Cory S. Goldberg BSc, MD, MASc, FRCS(C), FACS, MBA is a Plastic Surgeon with a fellowship in the Royal College of Physicians and Surgeons of Canada. 

He is a diplomat of the American Board of Plastic Surgeons and is also a Fellow of the American College of Surgeons. He earned his MD degree from Queen’s University, Canada and completed his Plastic Surgery residency training at the University of Toronto, including a Master’s of Applied Science in Biomedical Engineering. He subsequently did sub-specialty fellowship training in Craniofacial Plastic Surgery at University of Southern California in Los Angeles, California.

Dr. William Stanford MD PHD FACP

[email protected]

Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.

A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills

Sponsored by: Biography Health

Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.

From Flight Medic to Precision Medicine with Dr. Kat Schmolly

In this episode, we're joined by Dr. Kat Schmolly. From her adventurous past as an Air Force Flight Medic to her current mission revolutionizing rare disease diagnosis, Dr. Schmolly shares her unique journey into precision medicine. We discuss why bringing personalized care to the frontlines of medicine is crucial, and explore how innovative technologies can transform the future of healthcare.

Timestamps:

2:58 - How Dr. Schmolly and Dr. Stanford connected over precision medicine

7:35 - Early observations of environmental impacts on military health

13:22 - The near-disaster flight mission that changed her path

26:43 - Why precision medicine stays in research vs clinical practice

43:58 - Starting ZebraMD to transform rare disease diagnosis

47:19 - Vision for bringing precision medicine to primary care

Dr. Kat Schmolly

linkedin.com/in/kat-schmolly

[email protected]

Dr. Kat Schmolly is a physician at Dartmouth Health, combining her clinical expertise with a passion for advancing personalized medicine. As the founder of ZebraMD, she focuses on innovative solutions for rare disease diagnostics through algorithm development and AI-powered clinical tools. A graduate of the David Geffen School of Medicine at UCLA, her work has included groundbreaking research in genetic and rare diseases.

Before pursuing medicine, Dr. Schmolly served as a flight medic in the United States Air Force, where she honed her skills in aerospace and critical care medicine. With experience ranging from cardiac R&D at Medtronic to porphyria research and precision medicine development, Dr. Schmolly continues to lead efforts that bridge cutting-edge technology with patient-centered care.

Dr. William Stanford MD PHD FACP

[email protected]

Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.

A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills

Sponsored by: Biography Health

Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.

A Doctor's Mission: How Dr. Scoles Used Genetics to Transform Patient Care with Dr. Lyndell Scoles

In this episode, we explore pharmacogenomics, also known as genetic pharmaceutical profiling with Dr. Lyndell Scoles with MDVIP. He’s an early pioneer in using genetic testing to optimize medication choices. With over 30 years of experience in internal medicine, Dr. Scoles shares how genetic pharmaceutical profiling helps determine which medications will work best for each patient based on their unique genetic makeup. He presents compelling examples of how this approach has prevented hospitalizations and improved patient outcomes, including cases of heart failure prevention and depression treatment. We also discuss why this hasn't been widely adopted yet in medical practice, despite its potential to save billions in healthcare costs.

Note: As our first in-person recording, you may notice some echo and compressed audio quality in portions of the conversation - we appreciate your understanding as we continue to improve our in-person recording setup.

Timestamps:

00:02:49 - Dr. Scoles begins explaining his journey into pharmacogenomics and why he started implementing it in his practice

00:08:28 - Description of how genetic testing is done through cheek swabs and the three-category report system

00:25:30 - Powerful patient case study about adjusting antidepressant dosing based on genetic testing

00:29:54 - Discussion of Metoprolol case studies and the 8% of patients who can't metabolize it properly

00:45:34 - Moving patient story about treating a 13-year ulcer patient successfully using genetic insights

00:50:35 - Resources for physicians to learn more about pharmacogenomics

00:52:43 - Contact information and closing thoughts

Dr. Lyndell Scoles

5734246494

https://www.mdvip.com/doctors/lyndellscolesmd

[email protected]

Dr. Lyndell Scoles is a dedicated MDVIP-affiliated physician with over three decades of experience in internal medicine, renowned for his compassionate, patient-centered approach to healthcare. A strong advocate for personalized medicine, Dr. Scoles has integrated pharmacogenomics—also known as genetic pharmaceutical profiling—into his practice, completing this innovative testing for over 600 patients. This approach empowers him to tailor treatments to the unique genetic makeup of each individual, enhancing outcomes and minimizing adverse effects.

Dr. Scoles graduated Magna Cum Laude as valedictorian from the University of Missouri School of Medicine, where he earned his Doctorate of Medicine in 1990. He completed his residency in Internal Medicine at the same institution and holds certifications from the American Board of Internal Medicine and the International Society of Clinical Densitometry.

Throughout his career, Dr. Scoles has held numerous leadership positions, including Chief of Internal Medicine at Boone Hospital Center, and served as Medical Director for several care facilities, including nursing homes and Alzheimer's care units. His expertise and dedication to excellence have earned him numerous accolades, such as being named a Castle Connolly Top Doctor (2022–2024) and appearing in Inside Columbia’s Medical Guide as one of Columbia’s Favorite Doctors (2016).

Dr. Scoles is a member of esteemed professional societies, including the American Medical Association and the American Society of Internal Medicine. His practice is guided by the principle of treating the whole person—balancing physical, mental, and spiritual wellness—and building meaningful partnerships with his patients to achieve optimal health.

Dr. William Stanford MD PHD FACP

Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.

A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills

Sponsored by: Biography Health

Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.

Ep. 15 - Beyond One-Size-Fits-All: The Science of Drug-Gene Interactions with Michelle Beckwith

This episode features Michelle "Shelly" Beckwith, a genetics pioneer since the 1990s who worked on the Human Genome Project. She breaks down how pharmacogenetic testing helps optimize medication choices by analyzing how patients' genetic variations affect drug metabolism. The discussion covers testing methods, insurance challenges, and the real-world implementation of pharmacogenetics in clinical practice. Through her work with MedTrait, Shelly explains how understanding a patient's genetic profile can lead to more precise medication dosing and better outcomes.

https://www.medtrait.net/

Timestamps:

00:02:34 - 00:04:18: Michelle Beckwith's Professional Background

00:04:19 - 00:08:34: Different Types of Genetic Testing

00:08:34 - 00:12:34: Technical Details of Testing Methods

00:12:34 - 00:27:24: Drug Metabolism & Clinical Applications

00:27:24 - 00:35:42: Population Genetics & Healthcare Access

00:35:42 - 00:45:52: Regulatory Environment & Future Challenges

00:45:52 - 01:12:32: Implementation & Practical Applications

01:12:32 - 01:14:10: Closing Remarks

—

Michelle Beckwith

[email protected]

Michelle Beckwith has been at the forefront of genetics since the 90s, contributing to projects like the Human Genome Project and co-founding a laboratory specializing in DNA Human Identity testing. Her work in clinical pharmacogenetics has evolved into the foundation of MedTrait, one of our key partners at Biography Health, providing genetic insights for personalized medicine. 

Dr. William Stanford MD PHD FACP

[email protected]

Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.

A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine

Sponsored by: Biography Health

Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.

Genotyping vs. Sequencing: What's the Difference?

In this episode, Dr. William Stanford, Dr. Yelena Bykhovskaya and Taylor Cu discuss various genetic testing methods. The conversation compares genotyping, exome sequencing, and whole genome sequencing, with an emphasis on whole genome sequencing, which provides the most comprehensive genetic information.

Timestamps:

00:03:22 - Discussion begins on what popular genetic testing companies use (genotyping)

00:05:09 - Explanation of how genotyping chips (microarrays) work

00:17:24 - Clarification on the difference between genotyping and sequencing

00:20:31 - Introduction of the book analogy to explain different genetic testing methods

00:23:32 - Discussion on the pros and cons of whole genome sequencing vs. exome sequencing

00:25:48 - Conclusion on why whole genome sequencing is becoming the preferred method

--

Dr. William Stanford MD PHD FACP

[email protected]

Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.

A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine

Dr. Yelena Bykhovskaya

[email protected]

Dr. Yelena Bykhovskaya is an accomplished scientist specializing in genetics and precision medicine. As the former Principal Scientist at Avellino Labs, she developed genetic tests for Mendelian and complex eye diseases using national and international collaborations. As the former Research Scientist at Cedars-Sinai, she made major advances in complex genetic eye diseases with groundbreaking genome-wide genetic analyses. Her earlier work in mitochondrial genetics led to major discoveries in maternally inherited deafness and other rare mitochondrial disorders. Holding a PhD in Biochemistry, Yelena has a publication record of widely cited forty-five articles in high-impact journals and delivered numerous oral and poster presentations at the national and international conferences, solidifying her leadership in genetic research.

Sponsored by: Biography Health

Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.

In this episode, Dr. Yelena Bykhovskaya, Chief Scientific Officer at Biography Health, shares her expertise in genetics. We explore the importance of both polygenic and monogenic risk scores in patient care. The conversation underscores the value of combining cutting-edge genetic analysis with traditional clinical factors in the evolving field of precision medicine, emphasizing the need for a comprehensive approach to patient care.

Resources Mentioned:

https://www.genomeweb.com/

https://www.insideprecisionmedicine.com/

Timestamps:

00:03:34 - LinkedIn sparks Bykhovskaya-Stanford collaboration

00:06:27 - Stanford highlights Bykhovskaya's genetic risk expertise

00:13:13 - Genetic risk vs. family history explained

00:18:18 - Human Genome Project revolutionizes genetic analysis

00:24:54 - Whole genome sequencing: Key to comprehensive risk assessment

00:28:49 - High polygenic scores rival monogenic variants in risk

00:33:33 - Early intervention: Combating genetic predispositions

00:38:09 - Integrated risk scores: Combining genetics and clinical factors

00:44:00 - Basic genetic knowledge empowers doctors

00:52:59 - Addressing European bias in genetic studies

Dr. William Stanford MD PHD FACP

Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.

A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills

Sponsored by: Biography Health

Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.

How Doctors are Using Genetic Data to Transform Patient Care with Philip Bretsky MD PhD MPH FACP

In this episode, we're joined by Dr. Philip Bretsky, a board-certified internist from Santa Monica with expertise in epidemiology and Alzheimer's research. Dr. Bretsky discusses how precision medicine is transforming healthcare by integrating genetics, biomarkers, and lifestyle factors. He explores the challenges and opportunities in implementing this approach, the evolving role of general practitioners, and how patients can advocate for personalized care. Dr. Bretsky also shares valuable resources for both health-conscious individuals and primary care providers interested in precision medicine. Join us for insights into the future of healthcare and strategies for better disease prevention and treatment.

Dr. Philip Bretsky's Contact Information:

Philip M. Bretsky MD PhD MPH FACP

1301 20th Street, Suite 230

Santa Monica, CA 90404

TEL: 310.828.4411

FAX: 310.828.2411

Facebook:@santamonicaprimarycare

Twitter / X: @santa_care

Instagram: @santa_monica_primary_care

Web:  www.drbretsky.com & www.santamonicaprimarycare.com

My monthly newsletter: https://lp.constantcontactpages.com/su/JtF9zzR

Timestamps:

03:18 – Dr. Philip Bretsky’s career path and personalized care.

09:26 – Shifting from treating to preventing disease.

12:02 – Gene-environment interactions and polygenic risk scores.

19:15 – Managing complex health problems as a general practitioner.

29:06 – Reflections on the Human Genome Project’s impact.

36:29 – Case study: Preventing coronary events.

44:17 – Advice for patients on advocating for personalized

Resources Mentioned:

Books:

• "Outlive" by Peter Attia
• "The Age of Scientific Wellness" by Leroy Hood
• "The Covenant of Water" by Abraham Verghese (fiction, but related to genetic conditions)

Podcasts/Newsletters:

• Eric Topol's substack and Twitter feed
• Peter Attia's podcast

Dr. William Stanford MD PHD FACP

Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.

A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field.

Sponsored by: Biography Health

Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.