In this episode, Dr. David Moskowitz shares how thousands of patients have avoided dialysis through genomic medicine — and why most kidney failure is preventable.

We dive deep into ACE genes, repurposed drugs like quinapril and ProGraph, and explore what genomic insights could mean for diseases like Alzheimer's and cancer.

Heads up: this one gets detailed with a lot of medical terminology. If you're curious but lost, drop the transcript into ChatGPT — it'll help translate the science.

Dr. David Moskowitz - genomed.com

Takeaways

Dialysis is preventable, and awareness is crucial.

Innovative approaches can challenge traditional medical practices.

ACE inhibitors should be the first line of defense in kidney health.

Genetic factors play a significant role in Alzheimer's disease.

Whole genome sequencing can provide insights into various diseases.

Repurposing existing drugs may offer new treatment avenues.

The healthcare system often resists change due to financial incentives.

Public health initiatives need to focus on improving outcomes.

Understanding the molecular basis of diseases can lead to better treatments.

Collaboration and communication in medicine are essential for progress.

Chapters

00:00 Introduction to Preventive Medicine and Genomics

04:53 The Journey to Preventing Kidney Disease

07:35 Innovations in Kidney Health: The Role of ACE Inhibitors

10:14 Challenges in the Healthcare System

12:45 The Impact of Lifestyle on Kidney Health

15:38 Exploring the Connection Between COVID-19 and Kidney Disease

17:50 The Future of Genomics in Preventive Medicine

20:10 Patient Empowerment and Navigating Healthcare

22:57 Key Takeaways

39:31 Exploring Whole Genome Sequencing in Alzheimer's

42:16 Iron Overload and Neurodegeneration

46:36 mTOR Pathway and Alzheimer's Treatment

48:29 Repurposing Drugs for Alzheimer's and Other Neurodegenerative Diseases

55:09 Genetic Risk Factors for Alzheimer's

57:00 Innovations in Cancer Detection

01:02:47 Differentiation Therapy in Cancer Treatment

01:08:38 The Importance of Personalized Health

Dr. William Stanford MD PHD FACP

[email protected]

Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.

A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field.

Sponsored by: Biography Health

This episode is sponsored by Biography Health — where DNA-powered healthcare is designed just for you. Biography Health is a HIPAA-compliant precision medicine platform that equips providers with AI-driven recommendations powered by your genetics, health history, and clinical insights — all while keeping data private, secure, and independent from large EHR systems.

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.