JCO Precision Oncology Conversations

JCO PO author Dr. Bryson Katona shares insights into the JCO PO article, "Longitudinal Pancreatic Imaging Findings in BRCA1, BRCA2, ATM, and PALB2 Heterozygotes Undergoing Pancreatic Cancer Surveillance: A Prospective PRECEDE Consortium Study." Host Dr. Rafeh Naqash and Dr. Katona discuss how, in this largest reported cohort of BRCA1, BRCA2, ATM, and PALB2 heterozygotes undergoing PC surveillance imaging, benign/low-risk pancreatic imaging findings were common and stable on short-term follow-up, providing important data for counseling these HRIs.

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JCO PO author Melyssa Aronson shares insights into the JCO PO article, "Assessment of the 2022 Constitutional Mismatch Repair Deficiency syndrome (CMMRD) diagnostic criteria using the International Replication Repair Deficiency Consortium (IRRDC)." Host Dr. Rafeh Naqash and Professor Aronson discuss how refinement of CMMRD diagnostic criteria may address atypical presentation and discordant functional results.

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JCO PO authors Dr. Kristin Kohler, Heather Hampel, and Dr. Michael Hall share insights into the JCO PO article, "Redefining the EPCAM Phenotype: Deletion Architecture Determines Lynch Syndrome Cancer Risk." Host Dr. Rafeh Naqash and guests discuss how the findings provide new insights into the molecular and clinical heterogeneity of germline deletions involving EPCAM.

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In this JCO PO Article Insights episode, host Dr. Carolyn Lineen summarizes the article, "Evaluation of a Tumor-Informed Molecular Residual Disease Assay in Early Triple-Negative Breast Cancer Treated With Neoadjuvant Chemotherapy, With or Without Atezolizumab" by Balic and colleagues.

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JCO PO authors Dr. Melina Marmarelis and Dr. Charu Aggarwal at University of Pennsylvania share insights into the JCO PO article, "EMBER-Lung: Electronic Medical Record Boosting Molecular Testing in Early-Stage NSCLC." Host Dr. Rafeh Naqash and guests discuss how embedding behavioral nudges within clinical workflows can help overcome barriers to biomarker testing in early-stage NSCLC.

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In this episode of JCO Precision Oncology Article Insights, host Jiasen He summarizes the article, "Beyond the Brain: Circulating Tumor Cells as a Tool for Diagnosis and Monitoring," by Lessi and colleagues.

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JCO PO Editor-in-Chief Emeritus Dr. James Ford and Founding PI, ASCO TAPUR Study, Dr. Richard Schilsky discuss the 10-year anniversary of the Targeted Agent and Profiling Utilization Registry (TAPUR)™ Study and its relationship with the journal. Host Dr. Rafeh Naqash and guests discuss the inception/history of the TAPUR study, its future, and advances in precision medicine over the past decade.

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In this JCO PO Article Insights episode, host Carolyn Lineen summarizes the article, "Breast Neuroendocrine Carcinoma: Molecular Insights Beyond Histology" by Schwartz and colleagues.

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JCO PO authors Dr. James Hadfield, Dr. Grace Yiqing Zhao, and Dr. Julia Elvin at AstraZeneca share insights into the JCO PO article, "Beyond Circulating Tumor DNA for Efficacy: Can We Use Cell-Free DNA to Detect and Monitor Toxicity Signals?" Host Dr. Rafeh Naqash and guests discuss emerging evidence that cfDNA methylation profiling provides sensitive, specific signals of tissue injury across multiple organs and clinical contexts.

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In this episode of JCO PO: Article Insights, host Jiasen He summarizes the article, "Clinical Liquid Biopsy Testing for Detection of Actionable Genomic Alterations in Children and Young Adults With Advanced Solid Tumors on the GAIN Study," by Roberts and colleagues.

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