Preprints in Motion

This week we discuss mitochondrial DNA and its importance in aging with Amy Vandiver (@AmyVandiver2). We also highlight a new method to quickly sequence full length mitochondrial DNA allowing for mitochondrial genome comparisons and the understanding of the diversity between mitochondrial DNA.  As usual we also discuss the process of pre-printing, preLights and how they can generate collaborations. As well as understanding more about the MD PhD group leader route.

Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.02.23.480720v2.full

This episode was produced by Emma Wilson and edited by Jonny Coates.

Use the code “jonny” to get free access to an online course all about preprints: https://courses.karger.com/courses/take/how-to-decide-on-preprints-and-open-access-licence/texts/28775362-introduction

If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated.

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_). Any additional sound effects used are from https://www.zapsplat.com.

This week we discuss a different take on sharing scientific findings with Alex Freeman (@alex_freeman), creator of Octopus @science_octopus. Octopus is resetting the incentive structure for research sharing, putting the emphasis on assessing the quality of what people are doing within the lab.

Find out more here https://www.jisc.ac.uk/rd/projects/octopus-creating-a-new-primary-research-record-for-science

Use the code “jonny” to get free access to an online course all about preprints: https://courses.karger.com/courses/take/how-to-decide-on-preprints-and-open-access-licence/texts/28775362-introduction

This episode was produced by Jonny Coates and edited by Camila Valenzuela.

If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated.

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss macrophage heterogeneity with Graham Heieis (@GrahamHeieis), a Post-doc at the Leiden University Medical Center (@LUMC_Leiden) in the Netherlands. We speak to him about mass cytometry and spectral flow cytometry and their use to investigate heterogeneity of tissue specific macrophages with regards to metabolism. We then have our usual chat about preprints, moving labs from Canada to Scotland as well as a bit of a a whiskey discussion. 

Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.05.26.493548v1.full

This episode was produced by Emma Wilson and edited by John D Howard.

If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated.

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_). Any additional sound effects used are from https://www.zapsplat.com.

We’ve gone full circle!! Join us this week as we talk to Michele Avissar-Whiting (@maw_tweets), one of our first ever guests on this podcast and Editor in Chief of Research Square, as we discuss what happens to a preprint when the downstream publication gets retracted, how the papers can be linked to the preprint and if the preprint should be withdrawn. Michele talks to us about her recent paper which examines exactly this.

Read the full article: https://doi.org/10.1371/journal.pone.0267971

Other links:

Use the code “jonny” to get free access to an online course all about preprints: https://courses.karger.com/courses/take/how-to-decide-on-preprints-and-open-access-licence/texts/28775362-introduction

This episode was produced by Emma Wilson and edited by John D Howard.

If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated.

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_). Any additional sound effects used are from https://www.zapsplat.com.

This week we discuss cilia length, ciliopathies and Chlamydomonas reinhardtii (also known as ‘Chlamy’) with Brae Briggs (@BiggeBrae), a graduate student from at Dartmouth (@dartmouth),Geisel School of Medicine (@GeiselMed). We find out about a range of ciliopathies, the main composition of cilia as well as using ‘Chlamy’ as a model to study cilia length. We also discuss the difficulties of moving in the middle of a PhD and pandemic, open science principles including preprints as well as how we try to have healthy work life balance.

Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.04.18.488674v1.full

This episode was produced by Emma Wilson and edited by John D Howard.

If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated.

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

We’re 1 year old today! And to help celebrate our Birthday we have an extra long conversation with the incomparable Prachee Avasthi (@PracheeAC), Associate Professor at Dartmouth, President of ASAPbio and CSO & co-founder of Arcadia Science). We discuss everything from Prachee’s career journey, role in promoting preprints and open science with ASAPbio and how she came to co-found Arcadia Science.

Read more about what we have achieved in our first year: https://preprintsinmotion.com/?p=913

This episode was produced by Emma Wilson & Jonny Coates and edited by John Howard & Jonny Coates.

If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated.

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss heart dedifferentiation and regeneration with Avraham Shakked @abingtonSA a final year PhD student, at the Weizmann Institute of Science, @WeizmannScience. We speak about their ingenious mouse model which uses transient and temporarily controlled ERBB2 expression which allows dedifferentiation and redifferentiation of cardiomyocytes. Using this model they examined the difference in RNA, protein and heart function in the redifferentiated the cells with and without heart injury. We also speak about preprints, publishing and alternative careers for scientists.

Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.02.22.481415v1.full

This episode was produced by Emma Wilson and edited by John D Howard .

If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints!

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss placental inflammation and heart development with postdoc Eleanor Jayne Ward and PI Suchita Nadkarni (@SciSuchita) from Queen Mary, University of London. In this preprint, the authors show that during embryonic heart development, neutrophils (innate immune cells) can sometimes cause placental inflammation. This inflammation leads to a loss of barrier function. In turn, this allows maternal monocytes (innate immune cells that develop into macrophages) to migrate into the embryonic heart. These monocytes alter the tissue resident embryonic macrophages and damage cardiac tissue. This cardiac damage continues postnatally. We discuss this and how limiting placental inflammation was enough to promote normal cardiac development. We also talk about the precarity of postdocs and why making research/postdoc a recognised profession would be an important step forward.

Read the full preprint on bioRxiv https://www.biorxiv.org/content/10.1101/2022.03.10.482611v1.full

Visit the Nadkarni lab website https://www.qmul.ac.uk/whri/people/academic-staff/items/nadkarnisuchita.html

Read more about the reasons scientists preprint https://www.biorxiv.org/content/10.1101/833400v1

This episode was hosted by Jonny Coates, produced by Emma Wilson and edited by John D Howard.

If you enjoyed this show then hit the subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated.

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss a population of stem cells called tanycytes which line hypothalamus in the brain with Alex Moore (@alexthemessiah) an Operational Research Analyst in the Civil Service & Kavitha Chinnaiya a Post Doc from the University of Sheffield (@sheffielduni).  Tanycytes are population of cells which line the 3rd ventricle in the hypothalamus, self renew and give rise to neurons and glia within the brain. We speak to them about the key findings of their paper which includes expanding on their roles as stem cells, as well as further characterising them with a variety of markers including NrCAM. To do this they evoked a range of techniques including the use of spheroids and single cell RNA sequencing and we chatted to them about those. We also find out about working in the Civil Service and all the skills that PhD offers that helped with this move from academia.

Read the full preprint: https://www.biorxiv.org/content/10.1101/2021.12.15.472761v1.full

This episode was hosted by Jonny Coats, produced by Emma Wilson and edited by John D Howard .

If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated.

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

CW:// This week's episode touches on some themes revolving around caloric restriction which some listeners may find difficult.

This week we speak to Ben Thomas @BenThomasSci, a final year PhD student at the University of Edinburgh @EdinburghUni about the benefits of caloric restriction, the impact in male and female mice as well as the effect of age. We highlight the ingrained sexisim within the biological sciences: often only male mice are used and we discuss how this can impact the results of various studies.

In addition, we discuss the Edinburgh Open Research Initiative @edinburgh_open which promotes awareness and training of open research principles and lobby’s for these to become formalized within the University of Edinburgh. We also discuss how incentives in science have led to a potentially flawed system and how his experience as a teacher has helped him in academic science.

Read the full preprint:

Other links:

This episode was produced by Emma Wilson and edited by John D Howard .

If you enjoyed this show then hit that subscribe button and leave a review (on Apple Podcasts or Spotify). If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints! Any contribution is greatly appreciated.

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).