Preprints in Motion

This week we discuss how journalists approach using preprints with Alice Fleerackers (@FleerackersA), a PhD student at the Simon Fraser University (@SFU). She tells us how she went behind the scenes and to examine the decision making process of journalists on whether to use preprints or not, how they contextualized the science, and what practices they use to evaluate preprints. We discuss the benefits of preprints and highlight the importance of science communication and our role as scientists to prevent the spread of misinformation.

Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.02.03.479041v1.full

This episode was produced by Emma Wilson and edited by Jonny Coates and John D Howard.

If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then buy us a coffee https://www.buymeacoffee.com/preprints!

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss organoids and assembloids as models of neurodegenerative diseases with Sònia Sabaté Soler (@scisonias), a PhD student from the University of Luxembourg (@uni_lu). Find out about how 2D stem cells cultures are differentiated into complex 3D midbrain organoids which contain multiple cell types. We also discuss how microglia can be incorporated into the organoids to generate assembloids, mimicking the human brain more robustly. As always we speak about pre-printing and academic culture. We touch on some of the limitations on academia partially with reference to women in STEM and the potential of permanent post docs. .

Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.01.21.477192v1.full

This episode was produced by Emma Wilson and edited by John D Howard .

If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on buy me a coffee https://www.buymeacoffee.com/preprints. Any contribution is greatly appreciated.

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

A really exciting special episode this week, as we talk to co-founders of BioRxiv (@biorxivpreprint) and MedRxiv (@medrxivpreprint) Richard Sever (@cshperspectives) & John Inglis (@JohnRInglis). We discuss how they met and started with BioRxiv along with the challenges they faced. We then chat about the considerations when accepting or rejecting preprints, or why certain papers are rejected from BioRxiv (they don’t just accept everything).  We also touch on the impact COVID 19 and the pandemic had on preprints as well as discuss the fraudulent papers and how they don’t tend to be pre-printed. If you’ve ever been concerned about preprints this is a great episode to learn more about how preprint servers work and what the future may hold for BioRxiv from the key people in the field.

Other links

BioRxiv - https://www.biorxiv.org/

This episode was produced by Jonny Coates and Emma Wilson and edited by John D Howard .

If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month!

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss DNA recorders with Theresa Loveless (@TheresaLovele12), a Post Doc, at UC Irvine. DNA recorders can turn transient events into stable genomic ones and have been used to investigate cell fates and lineages. Join us as we find out more about how this is achieved and the incredible technology behind it!! We also chat about Theresa’s experience of preprinting and academia, and how it can be improved!!

Read the full preprint

Whole-organism lineage tracing by combinatorial and cumulative genome editing: https://pubmed.ncbi.nlm.nih.gov/27229144/

molecular recordings by directed crispr spacer acquisition

Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts

Prime Editor: https://www.nature.com/articles/s41434-021-00263-9

If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month!

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss an amazing new technique developed by Dr Jakub Gemperle (@GemperleJakub), a Marie Curie Postdoctoral Research Fellow at the University of Manchester (@OfficialUoM). This technique uses 3 different inducible systems to allow on-demand control of endogenous genes, including being able to remove genes and then re-express them. A nice all in one package of techniques, great for rescue experiments!! We then also talk about Magnetogenetics where cells (and vesicles) can be moved around via magnets! As always we ask how this person found preprinting and we delve into the wonderful idea of permanent postdocs.

Read the full preprint: https://www.biorxiv.org/content/10.1101/2021.12.03.471086v1.full

Other links

First Pig to Human heart transplant

This episode was produced by Emma Wilson and edited by John D Howard.

If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month!

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

This week is our Christmas Episode! In this episode the Preprints in Motion team get together and discuss exciting, new preprints with a festive theme. We talk about smart soil, mitochondria DNA in relation to COVID 19, shock absorber stress granules as well as a discussion on nepotistic journals and much more including festive cheer and merriment.  

Read the full preprints:

https://www.biorxiv.org/content/10.1101/2021.11.19.468202v1

https://www.biorxiv.org/content/10.1101/2021.04.26.441141v1.full

https://www.biorxiv.org/content/10.1101/348508v1.full

https://www.biorxiv.org/content/10.1101/2021.02.03.429520v1?rss=1

https://www.biorxiv.org/content/10.1101/2020.02.07.938555v1.full

This episode was produced by Emma Wilson and edited by John D Howard .

If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month!

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss the exocyst with Dr Hannes Maib @hannes_maib a Post-Doctoral Researcher at the University of Dundee @dundeeuni!! He explains the complexities of the exocyst as well as the exciting biochemistry and binding assays used to understand its formation. In addition Hannes speaks candidly about starting working in a new lab as a Post-Doc, his views of hierarchical journal systems and how preprinting can help ECR take back ownership of their work in a great discussion with our host Dr Jonny Coats.

Read the full preprint -> https://www.biorxiv.org/content/10.1101/2021.10.14.464363v1.full

Other links -> LINK

This episode was produced by Emma Wilson and edited by John D Howard .

If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month!

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss prefigurative politics in academia with Stefano Davide Vianello, a PhD student at @EPFL_en in Switzerland. This is the idea that in order to change how a system works we should act in a way that reflects the change we want to see. In Stefano’s case: preprinting to be the end goal and he has therefore submitted a preprint without any intention of submitting it to a journal. We speak to him about his reasons for this, why he is against academics paying for open access as well as 4 key points on what has to change to make academia more open for everyone, not just the global north.

Read Stefano’s preprint: https://www.biorxiv.org/content/10.1101/2020.06.07.138883v3

Read Stefano’s opinion piece: https://commonplace.knowledgefutures.org/pub/vzn21ssv/release/2

This episode was produced by Jonny Coates and Emma Wilson, with editing by John D Howard.

If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month!

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss mice in space and the impact of prolonged space flight and how this can relate to austraunoughts with Jessica L Braun @jess_l_braun a PhD Student at the Brock University @BrockUniversity. Jessica speaks about her work looking at soleus and tibialis anterior muscles of mice which have spent 35-37 days on the international space station comparing Ca2+ uptake and SERCA function. We discuss everything from a mice mission control to cardigan rhythms and the different effects on males and female mice. We also talk about preprints and the increased attention it can bring as well as how to improve public engagement.

Read the full preprint: https://www.biorxiv.org/content/10.1101/2021.09.27.462048v1.full

This episode was produced by Emma Wilson and edited by John D Howard.

If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month!

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).

This week we discuss Parkinson’s Disease and single molecule spectroscopy with Dr Derrick Lau, a PostDoc at the University of New South Wales (@UNSW). Single molecular spectroscopy can be used to track the formation and purification of α-synuclein aggregates, a hallmark of PD, and potentially lead to a tool for early diagnosis of Parkinson’s Disease. We discuss how single molecular spectroscopy is transferable to medium throughput and use bio fluids for early diagnosis of Parkinson Disease but also potentially other neurodegenerative diseases. Finally, we discuss preprints, what it it like to apply for PostDocs in a pandemic as well transitioning from immunology and neuroscience. 

Read the full preprint - https://www.biorxiv.org/content/10.1101/2021.08.09.455607v1.full

Other links

Microbiome in PD- https://www.nature.com/articles/s41531-021-00156-z

Immunotherapy in PD - https://pubmed.ncbi.nlm.nih.gov/31978602/

α-synuclein in PD patients biofluides - https://pubmed.ncbi.nlm.nih.gov/32444560/

AttoBright - https://www.nature.com/articles/s41467-019-13617-0

https://www.nature.com/immersive/d41586-021-02563-x/index.html

This episode was produced by Emma Wilson and edited by John D Howard .

If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month!

For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.

Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).