Tonight on the Last Word: President Biden gives his first primetime speech after signing the COVID relief bill. Also, Biden prepares to fill key federal judicial vacancies. Plus, the New York State Assembly begins an impeachment investigation against Gov. Andrew Cuomo. And Anand Giridharadas talks to Lawrence about how the COVID relief bill shows important changes in American conventional wisdom. John Heilemann, Jennifer Palmieri, Sen. Sheldon Whitehouse, Andy Slavitt and Latrice Walker also join Lawrence O’Donnell.