Andrew Stokes, PhD joins JAMA Network editors to discuss a cross-sectional study using data from the National Health and Nutrition Examination Study to evaluate trends in prescription opioid use and nonopioid analgesic use from 1999 to 2016 among US adults with functional limitations attributable to musculoskeletal conditions. Read the article here: https://ja.ma/36OWL5t. JNO Live is a weekly broadcast featuring conversations about the latest research being published in JAMA Network Open. Follow us on Facebook, Twitter and YouTube for details on the next broadcast.