Solvonis Therapeutics PLC (LSE:SVNS) CEO Anthony Tennyson talked with Proactive's Stephen Gunnion about the company’s exciting developments regarding AWKN-002, a drug candidate targeting moderate to severe alcohol use disorder. Tennyson highlighted the significant unmet medical need in the US, where 29 million people suffer from alcohol use disorder and 75% relapse within a year after treatment.

In December, Awakn Life Sciences, which Solvonis plans to acquire, received positive feedback from the FDA during a pre-IND meeting. The FDA approved the company’s proposal to skip Phase 2a trials and proceed directly to Phase 2b. Furthermore, it supported Awakn’s expedited regulatory pathway through the 505(b)(2) process, allowing reference to J&J’s Spravato data.

Tennyson explained that AWKN-002 is a repurposed version of esketamine delivered through an oral thin film for sublingual administration. He added, “This clarity from the FDA reduces time and provides a clear direction for the R&D program.” The next step involves establishing a scientific bridge to SPRAVATO before seeking Phase 2b approval.

Watch the video for more updates, and don’t forget to like, subscribe to Proactive’s channel, and enable notifications for future videos!

#SolvonisTherapeutics #AWKN002 #AlcoholUseDisorder #FDAApproval #PharmaceuticalInnovation #SKetamine #AddictionTreatment #BiotechUpdates #MedicalResearch #ProactiveInvestors

Ilika PLC (AIM:IKA, OTCQX:ILIKF) CEO Graeme Purdy talked with Proactive's Stephen Gunnion about the company’s progress in the first half of its 2025 financial year, highlighting developments in both the Stereax and Goliath battery lines.

Purdy shared that the commercial production of Stereax is well underway, with the first revenues expected this year. He detailed how a licensing agreement with Cirtec Medical has streamlined the transfer of equipment and enabled the initiation of production batches, with customer integration set to follow.

Regarding Goliath, Purdy explained the successful testing of P1 prototypes and the significant progress in safety performance. The company’s D6 milestone resulted in a 10Ah battery, which is five times larger than the previous prototypes. This summer, Ilika aims to release its next round of prototypes and is on track to develop its P2 minimum viable product by year-end, which could spark manufacturing and licensing opportunities.

Despite extensive development, Ilika ended the period with a cash position of over £10 million, surpassing market expectations. Purdy emphasised the company’s efficiency, noting it has achieved significant progress with limited resources.

Stay tuned for updates on Stereax commercialization and Goliath's next prototypes.

Visit Proactive's YouTube channel for more updates like this, and don’t forget to like, subscribe, and enable notifications for future videos.

#Ilika #BatteryTechnology #Stereax #Goliath #SolidStateBatteries #CleanEnergy #EnergyStorage #CirtecMedical #TechInnovation #ElectricVehicles #BatterySafety #Sustainability

KEFI Gold and Copper PLC (AIM:KEFI, OTC:KFFLF) executive chairman Harry Anagnostaras-Adams talked with Proactive's Stephen Gunnion after the English High Court of Justice, King’s Bench, handed down its judgement in relation to a case against the company that dismissed all claims against KEFI and awards to KEFI all of its counterclaims.

Anagnostaras-Adams described it as a significant step, allowing KEFI to fully focus on financial closing and project development.

He elaborated on the company's banking processes, noting that critical conditions have been met and approvals are being finalised. He called this phase "home-stretch territory," emphasising KEFI’s readiness to launch its high-grade, high-recovery project in Ethiopia, which had faced delays due to political and regulatory challenges.

From Saudi Arabia, the executive outlined KEFI’s role as a pioneer in recent discoveries and discussed the opportunities arising from the Future Minerals Forum. He revealed that KEFI’s Saudi operations are under strategic review, with significant interest from potential backers and buyers.

Summing up, he stated, "It’s all about implementation, de-risking, and launch now. We’re thrilled to be at this juncture."

For more updates on KEFI Gold and Copper’s journey, visit Proactive's YouTube channel. Don’t forget to like this video, subscribe to the channel, and enable notifications to stay informed!

#KEFIGoldAndCopper #MiningNews #EthiopiaProjects #GoldMining #SaudiArabiaExploration #FinancialClosing #FutureMinerals #CopperInvesting #ProactiveInvestors #MiningUpdates

Fathom Nickel CEO Ian Fraser joined Steve Darling from Proactive to share the company’s 2024 achievements and its forward-looking strategy for 2025 with Proactive. While acknowledging the challenges of navigating tough market conditions last year, Fraser highlighted notable advancements at the Gochager Lake and Albert Lake projects, both located in Saskatchewan.

For 2025, Fathom Nickel is prioritizing operational efficiencies, including the development of ice roads to reduce exploration costs, advancing geophysical studies, and gearing up for a targeted drilling program at Gochager Lake. The Albert Lake project remains a key focus, with Fraser emphasizing its potential to uncover new mineralization opportunities within Saskatchewan's rich and varied resource landscape.

Fraser expressed optimism about early 2025 trends, noting improving nickel prices driven by production cuts in Indonesia. He also revealed increased interest from potential strategic partners who are drawn to Fathom Nickel’s innovative exploration strategies and promising portfolio of assets.

These developments position Fathom Nickel to build momentum in the new year, further advancing its projects and leveraging favorable market conditions.

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Formation Metals CEO Deepak Varshney joined Steve Darling from Proactive to share the company has announced the signing of an option agreement to acquire an undivided 100% interest in the highly prospective N2 property from Wallbridge Mining Company Limited. This strategic acquisition bolsters Formation Metals' presence in the prolific Abitibi subprovince of Northwestern Quebec, a region known for its abundant gold resources and production history.

The N2 property spans 87 claims, encompassing approximately 4,400 hectares of land located 25 kilometers south of Matagami, Quebec. Conveniently accessible year-round via provincial highways and well-maintained logging roads, the property is situated along the Casa Berardi mine trend. This geological corridor hosts numerous world-class, multi-million-ounce gold deposits, further highlighting the potential of the N2 property.

Within the property, six known zones of gold mineralization have been identified. Four of these zones yielded a historical resource estimate of 18.2 million tonnes grading 1.48 grams per tonne gold at a cut-off grade of 0.5 g/t. Despite this promising historical data, the property has not been drilled since 2008, leaving the mineralization zones open for significant expansion both along strike and at depth.

Varshney emphasized the company’s plan to unlock the full potential of the property by advancing the known gold zones. Formation Metals will undertake drill programs designed to test extensions of the historical resources, focusing on expanding the mineralization along strike and deeper into the system. This targeted exploration strategy aligns with Formation Metals’ broader objective of building a portfolio of high-quality assets in renowned mining districts.

The acquisition of the N2 property marks an important step for Formation Metals as it looks to establish itself as a significant player in the gold mining sector, leveraging the untapped potential of this well-located and resource-rich asset.

#proactiveinvestors #formationmetals #cse #fomo #mining #gold #GoldExploration #JuniorMining #QuebecGold #AbitibiBelt #MiningUpdates #BaseMetals #GoldInvesting #ResourceGrowth

hVIVO Plc CEO Yamin “Mo” Kahn joined Steve Darling from Proactive to share details of a landmark achievement for the company. hLAB, the Group’s standalone virology and immunology laboratory service provider, has signed its largest contract to date—a $2.7 million pound deal with a US-based biotechnology client. This agreement brings the total project value to $3.2 million pounds and further solidifies hLAB’s position as an industry leader in virology and clinical trial support.

With over 20 years of expertise in testing for quarantine and contracted studies, hLAB will serve as the sole virology laboratory for an international, multi-site Phase 2 field study. The study, involving 5,000 subjects, focuses on evaluating a US biotechnology client’s influenza drug candidate. Work is set to begin immediately, with hLAB providing critical virology and immunology lab services throughout the trial’s duration.

“This milestone contract represents a significant validation of hVIVO’s expertise and capabilities,” Kahn stated. “It is the largest standalone laboratory services agreement in the company’s history and marks a pivotal step in expanding our footprint in the virology and immunology space.”

The majority of the revenue from this contract is anticipated in 2025, with the remainder recognized in 2026. This deal not only reinforces hVIVO’s reputation for excellence in clinical trial support but also signals continued growth opportunities for its standalone laboratory services.

With this contract, hVIVO is poised to make a meaningful contribution to the development of cutting-edge treatments for influenza, demonstrating its unwavering commitment to advancing global health through innovation in virology and immunology.

#proactiveinvestors #hvivo #aim #hvo #mokahn #ClinicalTrials #InfluenzaResearch #Virology #Immunology #hLAB #CanaryWharf #BiotechNews #DrugDevelopment

Proactive’s Tylah Tully breaks down ‘Just the Facts’ of the latest news from Kali Metals Ltd (ASK:KM1).

Kali shares rose 21% in early ASX trading following the expansion of a gold-in-soil anomaly at the Marble Bar Gold-Lithium Project in Western Australia.

Analysis of 619 historical soil samples increased the anomaly’s length by 80%, now totalling 9.5 kilometres.

Initial fieldwork has mapped less than 1 kilometre of the anomaly, identifying the Tiger and Sherman prospects. These prospects feature gold-bearing quartz veins up to 7 metres wide and 120 metres long, with surface grades reaching up to 4 g/t gold.

The company plans to resume fieldwork this quarter to ground-truth the remaining anomaly, aiming to identify and define drill targets.

Kali expressed optimism about the results, stating that gold exploration will now be the primary focus at Marble Bar, with lithium exploration remaining secondary.

At the Panther lithium prospect, trenching returned average grades of 0.14% and 0.48% lithium across two channels, pointing to additional lithium potential within the project.

#ProactiveInvestors #KaliMetals, #MarbleBarProject, #GoldExploration, #TigerProspect, #ShermanProspect, #ASXStocks, #GoldAnomaly, #LithiumExploration, #WesternAustraliaMining, #CriticalMinerals, #GoldMining, #MineralsExploration, #ResourceDevelopment, #GoldQuartzVeins, #MiningUpdates, #DrillTargets, #AustralianMining, #PantherLithium, #InvestingInMining, #MiningNews

Proactive’s Tylah Tully breaks down ‘Just the Facts’ of the latest news from Recce Pharmaceuticals Ltd (ASX:RCEOTC:RECEF).

Recce has completed dosing for all 30 participants in its Phase II clinical trial of RECCE® 327 Topical Gel (R327G).

This trial focused on treating Acute Bacterial Skin and Skin Structure Infections (ABSSSI).

Conducted as an open-label study, it evaluated the safety, tolerability, pharmacokinetics and efficacy of R327G, applied daily over either seven or 14 days.

Preliminary results indicated complete cures or significant symptom improvement in participants, with no serious adverse events reported. The full trial results are expected in the first quarter of this year.

R327G is a synthetic anti-infective designed to address antibiotic-resistant infections.

The company highlighted its strong safety profile and efficacy, particularly in patients with highly resistant bacterial infections.

Recce plans to utilise the data to support regulatory submissions to the US Food and Drug Administration (FDA) and the Therapeutic Goods Administration (TGA).

A Phase III trial is scheduled to begin in Australia during the first half of this year.

#ProactiveInvestors #ReccePharmaceuticals, #ASX #ClinicalTrials, #Phase2Trial, #RECCE327, #TopicalGel, #ABSSSI, #AntibioticResistance, #SyntheticAntiInfective, #PharmaceuticalInnovation, #PatientSafety, #Efficacy, #FDAApproval, #TGAApproval, #DrugDevelopment, #HealthcareAdvances, #InfectiousDisease, #Australia, #Phase3Trial, #Biotechnology, #MedicalResearch

Proactive’s Tylah Tully unpacks the outlook for rare earth elements (REEs), critical for technologies like electric vehicles (EVs), wind turbines and advanced electronics.

These minerals have become central to geopolitical competition, with China dominating production.

In 2023, China classified rare earth resources as state-owned, introduced mandatory traceability systems and restricted key technology exports.

In response, the United States imposed tariffs on Chinese EVs and critical minerals, aiming to reduce dependence on Chinese supply chains and bolster domestic production.

Despite their abundance, the dispersed nature of rare earths makes extraction challenging.

Classified as critical minerals, they are essential for clean energy technologies and advanced defence systems.

Global demand is rising rapidly, with Australia, holding at least 4% of the world’s REE reserves, well-positioned as a key supplier.

Lanthanein Resources Ltd is exploring critical minerals across Western and South Australia, focusing on its Lady Grey Lithium-Tantalum Project. Drilling is underway, with results to guide further progress.

Lindian Resources Ltd is developing the Kangankunde Rare Earths Project in Malawi. A 2024 feasibility study highlighted its low costs, short payback period, and strong financial returns.

American Rare Earths Ltd is advancing its La Paz (Arizona) and Halleck Creek (Wyoming) projects in the US, with test mining underway and a pre-feasibility study planned for 2025.

Ionic Rare Earths Ltd owns 60% of the Makuutu Project in Uganda and is leading innovations in rare earth recycling through its Belfast demonstration plant, leveraging patented technologies to recover rare earth oxides from spent magnets.

Global demand and geopolitical pressures underscore the importance of sustainable REE supply chains, placing explorers and developers in a strategic position.

#ProactiveInvestors #RareEarthElements, #CleanEnergy, #ElectricVehicles, #WindTurbines, #CriticalMinerals, #LanthaneinResources, #LindianResources, #AmericanRareEarths, #IonicRareEarths, #MakuutuProject, #HalleckCreek, #KangankundeProject, #MiningInnovation, #GreenTechnology, #SustainableMining, #REERecycling, #NationalSecurity, #GlobalDemand, #EnergyTransition, #AustraliaMining

CleanTech Lithium PLC (AIM:CTL, OTCQX:CTLHF) executive chairman Dr Steve Kesler talked with Proactive's Stephen Gunnion about the company’s updated resource estimate for the Laguna Verde project in Chile and its broader development plans.

Kesler highlighted the updated resource estimate of 1.95 million tonnes of lithium carbonate equivalent (LCE) within the Laguna Verde Basin, with 1.63 million tonnes located in a CEOL polygon where the company holds over 80% of mining licenses. This progress supports the company's application for a Special Lithium Operation Contract (CEOL), which will be formally submitted to the Chilean government by the end of January.

The company is also preparing for an ASX listing and plans to complete its pre-feasibility study (PFS) by the end of the quarter. Montgomery & Associates, experts in lithium brine resource estimation, have reviewed the resource data and recommended additional drilling and feasibility work for further resource expansion and technical validation.

Kesler emphasised that these efforts align with CleanTech Lithium’s strategy to secure strategic investors and finance the project through its next stages, including the DFS and permitting phases. He also mentioned that additional drilling and larger-scale pilot plant production are planned for 2025 to enhance the resource and attract investors.

Stay tuned to Proactive’s YouTube channel for more updates on CleanTech Lithium and other projects. Don’t forget to like the video, subscribe to the channel, and enable notifications for future content!

#CleanTechLithium #LithiumResources #LagunaVerde #ChileMining #LithiumCarbonate #ASXListing #RenewableEnergy #GreenTech #BatteryMetals #LithiumInvestment