Proactive - Interviews for investors

PreveCeutical Medical Chairman Stephen Van Deventer joined Steve Darling from Proactive to share updates on the company’s strategic advances in gene therapy and its wholly-owned subsidiary, BioGene Therapeutics. BioGene focuses on addressing diabetes and obesity through innovative therapies targeting the PTP1B gene in the brain, which is also linked to colon and breast cancers.

Van Deventer emphasized the global need for new treatments in diabetes and obesity as key reasons for selecting these areas as initial targets. He stated, “Once we manage to get the proof of concept done and get it to commercialization, it's a very viable business plan.” The advancements aim to provide solutions for widespread health challenges while establishing a robust business opportunity.

The conversation also underscored the strength of BioGene’s team, which boasts deep scientific and corporate expertise, positioning the subsidiary to drive success in its mission.

Looking ahead, PreveCeutical plans to further its other programs by 2025. These include its Sol-Gel drug delivery platform, designed for efficient medication delivery, and its non-addictive analgesic program, which addresses pain management without the risk of addiction.

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North Bay Resources CEO Jared Lazerson joined Steve Darling from Proactive to share positive results from metallurgical studies conducted at the company’s Fran Gold Project in British Columbia. The studies demonstrated an impressive total gold recovery of 97%, achieved through a combination of 67% recovery by gravity separation and 30% by flotation.

The head grade, originally reported at 0.9 ounces per ton gold, was significantly upgraded during testing. Gravity concentration yielded 8.54 opt gold, followed by flotation results of 2.69 opt gold, producing a final combined concentrate of 11.23 opt gold—representing an extraordinary 12x concentration of the material.

Lazerson elaborated on the advanced methodologies employed, explaining that samples were digested using a three-acid microwave digestion system. This system applies precise microwave energy to heat the acid mixture evenly and rapidly, ensuring complete dissolution of the sample matrix. Following digestion, the emissions were analyzed using an optical emission spectrometer, enabling precise quantification of elements such as barium, calcium, cadmium, cobalt, chromium, copper, iron, potassium, lithium, magnesium, manganese, sodium, nickel, lead, strontium, and zinc.

The metallurgical grind study was conducted on 1,000-gram samples to determine the time required to achieve a target grind size of 90% passing 106 microns (um). Two portions of the material were milled accordingly and subjected to gravity separation and flotation testing, resulting in the exceptional recovery and concentration outcomes.

In addition to these metallurgical advancements, Lazerson provided updates on the loading and transportation of a 120-ton shipment of gold-bearing material to the company’s Bishop Gold Mill in California. The shipment, totaling 240,000 pounds, consisted of 82 super-sacks with an average weight of 2,900 pounds each. Lazerson highlighted that fewer sacks were required than anticipated, suggesting higher metal content, as gold at the Fran Project is often associated with up to 20% iron content. The first rail shipment has now been completed, with the initial load expected to arrive at its destination imminently.

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Oriole Resources PLC (AIM:ORR) CEO Martin Rosser talked with Proactive's Stephen about the company's progress at the Mbe gold project in Cameroon. Rosser shared an update on the maiden drilling campaign, which includes 24 holes over a 6,590-meter program. The initial results are promising, with the first hole extending 358 meters and showing geological similarities to earlier trenching studies.

Rosser emphasised the importance of the drilling program in identifying potential gold resources at depth, following significant surface results from soil sampling and trenching at the Mbe South prospect. The first assay results are anticipated early in the new year, and the program continues steadily with the second hole already underway.

Rosser concluded by expressing optimism about the campaign's outcomes and the upcoming analysis from the laboratory in Ghana.

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Rainbow Rare Earths Ltd (LSE:RBW, OTC:RBWRF) CEO George Bennett joined Proactive's Stephen Gunnion with details of an interim report on the company's Phalaborwa rare earth project. Bennett detailed the findings of the newly released interim study, emphasising its confirmation of the project’s economic viability despite two years of inflation since the Preliminary Economic Assessment (PEA).

He highlighted that the projected capital expenditure (CapEx) remained below inflation-adjusted expectations due to significant technical optimisations. Operating costs were also reported as highly competitive, with costs for magnet rare earths just above $40 per kilogram. Bennett reiterated the project’s potential to be one of the highest-margin rare earths projects outside China, supported by independent validation from Argus Media.

Bennett also outlined plans to further optimise operational efficiency, including exploring renewable energy options such as solar power. Additionally, the interim study did not include revenue projections from byproducts like gypsum, leaving room for potential upside in the final Definitive Feasibility Study (DFS), expected next year.

He added that the company is preparing its pilot plant in South Africa for separation and purity testing, with results expected in early 2025. Bennett concluded by expressing confidence in the project's robust fundamentals and the team's progress.

Visit Proactive's YouTube channel for more updates, and don’t forget to like, subscribe, and enable notifications to stay informed.

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​​​​​​​Ondo InsurTech PLC (LSE:ONDO) CEO Craig Foster talked with Proactive about the company’s milestones in 2024 and its plans for 2025. Foster highlighted the company's successful US expansion, driven by its LeakBot strategy, which has seen deployments with major insurers, including Nationwide. Revenue grew by 42% in the first half to £1.70 million, signalling the company’s inflection point in the US market.

Foster explained how partnerships have enabled the company to expand rapidly across 16 states, with other insurers like Indiana Farm Bureau joining as partners. He also discussed the NFU deal in the UK and the significant growth in Denmark, doubling the addressable market. Foster assured investors that Ondo's negative working capital model ensures sustainable growth without additional funding requirements.

"We've structured deals so customers finance our growth," Foster said, emphasising a strategic approach to managing working capital and achieving EBITDA-positive trading by the second half of 2025.

With more deals in the pipeline, Foster called 2025 an "exciting year" focused on expanding core markets in Denmark, Sweden, the UK, and the US.

Stay tuned to Proactive's YouTube channel for more insights, and don’t forget to like, subscribe, and enable notifications for future updates.

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Zero Candida Co-Founder and CEO Eli Ben-Haroosh joined Steve Darling from Proactive to share with Proactive that the company has been granted a final patent in South Africa as part of its efforts to establish a global patent portfolio. Applications have also been filed in the United States, Brazil, and Europe.

The company is developing an AI-driven smart tampon-like device that utilizes a therapeutic blue light with precise wavelength and intensity to achieve a 99.999% success rate in treating the Candida fungus overnight at the point of care. This groundbreaking technology targets Vulvo-Vaginal Candidiasis, a condition affecting 75% of women worldwide, and offers a chemical-free treatment without side effects.

Zero Candida’s innovative ZCT device is designed to bridge healthcare gaps, especially in underserved and developing regions. It enables hybrid medical services by collecting and transmitting treatment data to gynecologists in real time via a built-in Wi-Fi chip and VoIP, allowing for remote care, personalized treatment, and ongoing monitoring.

Ben-Haroosh emphasized that the device's combination of effectiveness, side-effect-free treatment, and seamless data integration responds to the growing demand for safer, non-invasive solutions in women’s health. The ZCT device represents a transformative step in accessible, high-tech gynecological care.

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Immunic Inc (NASDAQ:IMUX) CEO Dr Daniel Vitt takes Proactive's Stephen Gunnion through the company's transformative plans for 2025, emphasizing significant milestones and clinical developments.

Reflecting on 2024, Vitt highlighted progress in the ENSURE-1 and ENSURE-2 Phase 3 studies for relapsing multiple sclerosis (MS), which are on track for completion in 2026. A key achievement of the year was a successful interim analysis, which maintained the study's integrity without adjustments.

On the corporate front, Immunic secured a PIPE investment of up to $240 million, providing a cash runway into Q3 2025 based on the additional $80 million tranche. Vitt said the company also welcomed Jason Tardio as chief operating officer, whose extensive experience in MS commercialization will be pivotal as Immunic prepares for potential product launches.

Looking ahead, April 2025 will bring the clinical readout of the CALLIPER study for progressive MS. Vitt believes vidofludimus calcium has the potential to become the first holistic oral treatment for all forms of MS, a breakthrough based on promising Phase 2 and biomarker data.

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Hemogenyx Pharmaceuticals PLC (LSE:HEMO, OTC:HOPHF) CEO Dr Vladislav Sandler and non-executive director Peter Redmond talked with Proactive's Stephen Gunnion about key developments within the company.

Redmond explained the recent 400-to-1 share consolidation, intended to attract serious institutional investors.

Sandler shared insights from his attendance at the Chemical and Biological Defense Conference in Florida and the American Society of Hematology conference in San Diego. He emphasised growing interest in the company’s CAR-T program for treating acute myeloid leukaemia (AML), which is progressing towards its first clinical trials.

Sandler and Redmond also spoke about the significant breakthrough in the company’s CBR (Chimeric Bait Receptor) program, emphasising its potential impact alongside CAR-T development.

Hemogenyx Pharmaceuticals remains focused on delivering innovative treatments, expanding into pediatric CAR-T applications, and advancing its clinical programs. As Sandler stated, 'We may have a chance to partner with entities to develop one-day manufacturing, reaching the next level of CAR-T delivery.

Stay tuned for more updates on Hemogenyx’s innovative journey.

Visit Proactive’s YouTube channel for more videos. Don’t forget to like, subscribe, and enable notifications for future content!"

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Proactive’s Tylah Tully breaks down ‘Just the Facts’ of the latest news from Forrestania Resources Ltd (ASX:FRS).

The company has secured an additional tenement under a 12-month option adjacent to its Bonnie Vale Project, near Coolgardie in Western Australia’s Eastern Goldfields.

The new tenement, east of the company's existing holdings, includes the southern extension of the Kunanalling Shear Zone—a prominent regional structure associated with significant gold-bearing resources, such as Evolution Mining's 5-million-ounce Mungari Project.

The option agreement involves a $15,000 fee paid to Amery Holdings Pty Ltd. Upon expiration of the option period, Forrestania can acquire 100% of the tenement for $35,000, payable in shares based on a five-day volume-weighted average price at that time.

During the option period, Forrestania plans to conduct literature and historical data reviews, followed by fieldwork to validate findings.

The tenement is expected to feature in upcoming exploration programs, complementing ongoing drilling at the nearby Ada Ann prospect, where the company is awaiting assay results from recent reverse circulation drilling.

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Proactive’s Tylah Tully breaks down ‘Just the Facts’ of the latest news from Predictive Discovery Ltd (ASX:PDI, OTC:PDIYF).

The company has delivered strong gold results from resource development drilling at the Sounsoun target in the Argo area of its Bankan Gold Project in Guinea.

A key highlight includes 6 metres at 19.98 g/t gold from 13 metres, with a standout interval of 2 metres at 53.92 g/t gold from 15 metres.

Pending assay results from 10 additional holes will inform a maiden mineral resource estimate (MRE) for the Argo area, expected in Q1 2025.

The Sounsoun mineralisation is associated with a shear zone extending at least 300 metres along strike, showing excellent continuity and remaining open at depth.

Predictive Discovery remains committed to its strategy of advancing regional drilling programs to identify new deposits at the highly prospective Bankan Gold Project.

Drilling is focused on infilling existing patterns, testing extensions and supporting the maiden MREs for the Sounsoun, Fouwagbe and 800W targets. Regional exploration is ongoing in the northern NEB areas and southern Bokoro permit.

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