Proactive - Interviews for investors

Arecor CEO Sarah Howell and Principal Investigator Professor Thomas Pieber joined Steve Darling from Proactive to share promising updates from the company’s Phase I clinical trial of AT278, an ultra-concentrated, ultra-rapid acting insulin candidate designed for people with Type 2 diabetes and high body mass index (BMI). The trial results were presented at the prestigious 60th Annual Meeting of the European Association for the Study of Diabetes (EASD) in Madrid, garnering significant attention.

Howell explained that AT278 is a novel insulin formulation that accelerates insulin absorption following injection, even at high concentrations, which allows for lower injection volumes. In a double-blind, randomized, two-way crossover study, AT278 demonstrated a significantly faster pharmacokinetic (PK) and pharmacodynamic (PD) profile compared to NovoRapid® in Type 2 diabetes patients with high BMI. These results confirm previous findings in Type 1 diabetes patients, showing that AT278 can maintain its rapid action profile regardless of diabetes type or patient BMI.

Pieber says this breakthrough is seen as a critical development in the pursuit of next-generation, miniaturized insulin pumps, which could offer patients greater convenience and improve their quality of life. Additionally, the trial reported a favorable safety profile, with no safety concerns detected, further supporting the potential of AT278 as a game-changing therapy for diabetes management.

Arecor is now exploring various funding options, including potential co-development partnerships, to move forward with a clinical pump study. This study aims to further demonstrate AT278’s ability to enable truly miniaturized, longer-wear insulin pumps, which are highly sought after by both patients and healthcare providers, and hold the potential to significantly disrupt the diabetes treatment market.

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Torque Metals Ltd (ASX:TOR) managing director Cristian Moreno joins Proactive’s Tylah Tully to discuss the company’s maiden mineral resource estimate (MRE) of 250,000 ounces of gold at its Paris Gold Project in Western Australia's Goldfields.

The MRE totals 2.518 million tonnes at a grade of 3.1 grams per tonne (g/t) gold and includes resources from the Paris, HHH and Observation deposits. Notably, 22% of the Paris deposit resources are classified as "Indicated" under the JORC classification, with high recoveries exceeding 96%.

The resource includes both open-pit potential (190,000 ounces at 2.9 g/t gold) and underground potential (60,000 ounces at 3.8 g/t gold), supported by the near all-time high gold price of US$2,599 per ounce. To date, only 2.5 square kilometres of the project’s large 57-kilometre strike length have been explored.

Moreno highlighted the potential for expansion, with gold already identified outside the current MRE area. The company plans to further explore untested targets within the resource area and assess the project's toll-treat value proposition through a scoping study.

Torque Metals also aims to continue drilling within its tenements near world-class deposits like Invincible and Beta Hunt.

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International Graphite Ltd (ASX:IG6) CEO Andrew Worland joins Proactive’s Tylah Tully to discuss the company’s highly promising drilling results from its Springdale Graphite Project in Western Australia.

The diamond drilling program at the Mason Bay deposit revealed significant high-grade graphite mineralisation, with one of the standout results being 11 metres at 14.3% total graphitic carbon (TGC) from a depth of just 10.4 metres. This includes two sections of very high-grade graphite: 1 metre at 21.3% TGC and 3.1 metres at 26.5% TGC.

Worland noted that Springdale is becoming increasingly important for the high-growth lithium-ion battery market and other industrial sectors. The shallow depth and oxide-rich mineralisation at the site offer the potential for low-cost mining, as demonstrated in the project's January 2023 scoping study. The company sees significant expansion potential, with only about 25% of identified targets drilled so far.

Additional key results from the Mason Bay deposit include intersections such as 3.6 metres at 22.1% TGC, 33.2 metres at 12.0% TGC, and 6.11 metres at 11.4% TGC. Further drilling at the Springdale Central deposit is ongoing, with results expected soon.

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Condor Resources Director Quinton Hennigh joined Steve Darling from Proactive to provide an update on the company's upcoming drilling program at the Huinac Punta project. Hennigh explained that after careful negotiations and collaboration, the company has secured community approval to proceed with drilling in this culturally sensitive area, marking a significant milestone for the project’s development.

Huinac Punta holds substantial potential for high-grade carbonate replacement deposits (CRD) rich in silver, zinc, and lead. Hennigh outlined the extensive preparatory work conducted to date, which includes geological mapping, geochemical sampling, and geophysical surveys. These efforts have helped to identify highly promising CRD targets, positioning the project as a potential game-changer for the company.

In addition to Huinac Punta, Hennigh provided insights into another of Condor’s projects, Puca Mayo, which he described as a high-sulfidation system with significant alteration, hinting at the presence of a large-scale deposit. With all necessary permits now in place, Condor Resources is gearing up for a dynamic drilling season. Hennigh expressed optimism about the company's future, stating, "We’re aiming to position Condor as one of the more exciting drill discovery stage companies."

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Baselode Energy CEO James Sykes joined Steve Darling from Proactive to share exciting developments regarding the company’s recent radioactivity drilling results at the ACKIO uranium prospect, located in the Athabasca Basin region of northern Saskatchewan. During the drill program, 18 holes encountered anomalous radioactivity at depths of less than 100 metres from the surface, with half of these beginning at less than 50 metres. This is seen as an encouraging sign of near-surface mineralization, a critical factor in the economic viability of uranium deposits.

Sykes specifically highlighted the results of drill hole AK24-137, which intersected four distinct zones of radioactivity, each registering greater than 5,000 counts per second (cps), indicating the presence of significant uranium mineralization. Additionally, seven drill holes reported radioactivity readings exceeding 5,000 cps, while 13 holes reported composite intervals of anomalous radioactivity ranging from 11 to 42 metres in thickness across five separate zones.

These findings expand the known footprint of near-surface mineralization around Pods 1 and 7 and have uncovered new high-radioactivity zones in Pods 6 and 7, enhancing the company’s confidence in the continuity of mineralization across the ACKIO prospect. Overall, Baselode Energy considers the drill program a success, as it continues to build a more detailed understanding of the potential resource and future development opportunities in this promising uranium project.

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Astral Resources NL (ASX: AAR) Managing Director Marc Ducler joins Proactive’s Tylah Tully to discuss its outstanding metallurgical test results from the Mandilla Gold Project's Hestia, Eos, and Iris deposits.

These tests revealed high gold recoveries, rapid leaching, and low reagent consumption under coarse grind sizes and modest cyanide concentrations. At a 212µm grind size, recoveries achieved were 99.5% for Hestia, 98.8% for Eos, and 96.5% for Iris. These results confirm the exceptional metallurgical characteristics of the Mandilla project, similar to those previously demonstrated at Theia, the project’s flagship deposit.

Additionally, Astral is conducting an in-fill drilling program at Theia, having completed 70 holes for 6,500 metres. The drill rig has now moved to the Feysville Gold Project, where it is undertaking a 34-hole program to test extensions at the Kamperman deposit. Early drilling results have intersected significant quartz and sulphide mineralisation, indicative of gold-bearing lithologies. Mineral resource estimates for Think Big, Rogan Josh, and Kamperman at Feysville are expected later this month, with further updates for Hestia and Eos due in the December quarter.

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Conrad Asia Energy Ltd (ASX:CRD) founder, managing director and CEO Miltos Xynogalas joins Proactive’s Tylah Tully to discuss how the company has secured a gas sales agreement (GSA) with Sembcorp Gas Pty Ltd, a subsidiary of Sembcorp Industries Ltd, to sell the export portion of natural gas from the Mako gas field in Indonesia’s West Natuna Sea.

This agreement marks a key step in the commercialisation of the Mako field, which is the largest undeveloped gas field in the region. Conrad holds a 76.5% participating interest in the field.

This GSA, combined with a previous domestic sales agreement with PGN (Indonesia’s largest gas company), commits all of Mako’s contingent gas resources to buyers. The agreements represent major milestones towards a final investment decision, expected by Q4 2024, with production set to begin in 2026.

The GSA with Sembcorp has a contract term until January 2037, covering sales of up to 76 billion British thermal units per day (Bbtud), equivalent to 76.9 million standard cubic feet per day (mmscfd). The agreement also allows for additional sales of up to 35 Bbtud if required. The Mako gas field is part of Conrad’s broader portfolio of gas projects across Asia.

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Althea Group Holdings Limited (ASX:AGH) CEO Joshua Fegan joins Proactive’s Tylah Tully to discuss subsidiary Peak USA’s production and operations in the US cannabis beverages market.

Peak USA has established an emulsion manufacturing lab in Florida, enabling the production of cannabis-infused beverages using its proprietary emulsion, Envision™, which delivers THC. Initial production is linked to a joint venture with Flora Growth Corporation, with the launch of cannabis beverages under the Melo and Cloud Cola brands scheduled for the coming weeks. Melo will offer seltzers in wild berry, grapefruit and strawberry flavours, each containing 5mg of THC, while Cloud Cola will provide vintage cola, root beer and orange creamsicle sodas, each containing 10mg of THC.

The joint venture is negotiating with liquor distributors in key US states, including Florida, Texas, Georgia, South Carolina and North Carolina, and expects agreements soon. Online sales are set to begin in September 2024.

The US cannabis beverages market, currently valued at USD 966.92 million, is projected to grow significantly. Fegan expressed confidence in Peak USA’s market entry, with the Florida facility being a key component in ensuring product quality.

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Anson Resources Ltd (ASX:ASN, OTCQB:ANSNF) CEO Bruce Richardson joins Proactive’s Tylah Tully to discuss the latest developments at the company’s Green River Lithium project.

It’s received final approval from the State of Utah, Department of Natural Resources, Division of Water Rights, to appropriate water (brine) for lithium extraction at its Green River Lithium Project. The application, originally filed in July 2023 through the company’s subsidiary Blackstone Minerals NV LLC, was granted after a reconsideration process completed this month.

The approval permits the use of 19 cubic feet per second (0.54 cubic metres per second) of brine in a direct lithium extraction (DLE) process, with all extracted brine being returned to its original geological formation, making the process non-consumptive.

The Utah Division of Water Quality approved the company’s underground injection control (UIC) technical report for the “UIC Class 5 Spent Brine Return” well last month.

The extraction wells are planned for private land purchased by Anson in 2023, close to the proposed lithium extraction plant.

Richardson highlighted the company’s commitment to environmentally friendly practices, noting that the DLE process reduces environmental impact compared to traditional evaporation ponds. The project is progressing rapidly, with the recent completion of the Bosydaba #1 well and the commissioning of the Sample Demonstration Plan.

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Polymetals Resources Ltd (ASX:POL) executive chairman David Sproule joins Proactive’s Tylah Tully to discuss the funding the company has secured for the restart of its Endeavor silver, lead, and zinc mine north of Cobar, New South Wales.

The company announced a US$20 million (~A$30 million) loan facility and a favourable offtake agreement with Ocean Partners UK Ltd, a global commodities trader, for zinc and silver-lead concentrates. These developments mark the final step in ensuring the mine’s restart, which is expected to generate cash flow by the first half of 2025.

Polymetals’ mine plan projects a pre-tax value of A$414 million, with an internal rate of return (IRR) of 345%, and an estimated free cash flow of A$609 million over a 10-year operational period. Average annual EBITDA is expected to reach A$89 million during the first five years. Pre-production capital is set at A$28 million, with a maximum cash drawdown of A$30 million.

Sproule highlighted the importance of the strategic partnership with Ocean Partners, which provides flexibility for future growth. The Endeavor mine is on track to restart production by mid-2025, with surface and underground refurbishment currently underway.

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