Proactive - Interviews for investors

Dr. Seth Lederman, CEO of Tonix Pharmaceuticals, recently joined Steve Darling from Proactive to discuss the company's collaboration with Bilthoven Biologicals (BBio) to advance TNX-801, Tonix’s promising vaccine candidate for mpox. TNX-801 is a live, replicating, attenuated virus vaccine based on horsepox, currently in preclinical development to prevent both mpox and smallpox.

TNX-801 leverages cutting-edge technology with the potential to serve as a viral vector platform, enabling the development of recombinant versions to protect against other infectious diseases. BBio, a global leader in vaccine production, was selected by the European Union for its pandemic preparedness program, making them an ideal partner for this collaboration.

Dr. Lederman shared that TNX-801 has shown remarkable results in preclinical studies, demonstrating immune protection in animal models with better tolerability compared to vaccines based on 20th-century vaccinia viruses. Specifically, TNX-801 has been shown to protect non-human primates against a lethal challenge with intratracheal Clade 1 monkeypox virus. Following a single-dose vaccination, the vaccine not only prevented clinical disease and lesions but also significantly decreased viral shedding in the mouth and lungs, suggesting strong mucosal immunity and the potential to block forward transmission.

This collaboration between Tonix Pharmaceuticals and BBio represents a significant step forward in the fight against mpox and smallpox, and the technology behind TNX-801 may pave the way for future vaccines against a range of infectious diseases.

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Graft Polymer (UK) PLC CEO Anthony Tennyson takes Proactive's Stephen Gunnion through the progress the company has made in its commercial collaboration with Awakn Life Sciences.

Tennyson explained the collaboration is aimed at developing new therapeutics for trauma-related mental health disorders, including post-traumatic stress disorder (PTSD).

He noted that Awakn has successfully identified two aminoindane chemical series as lead candidates, marking a crucial step forward in drug development. These compounds show promise in improving treatment options for conditions like PTSD, which affects millions globally.

Additionally, synthesis pathways for these compounds have been defined, ensuring scalable production as the project advances towards more rigorous pharmacological testing.

To further bolster the collaboration, Charnwood Discovery, a UK-based leader in drug discovery services, has been selected as the synthesis partner.

Also, a new provisional patent was filed on August 27 with the US Patent and Trademark Office.

For more insights into Graft Polymer's growth strategy and technological innovations, be sure to watch the full interview. Don’t forget to give the video a like, subscribe to the channel, and enable notifications for future content.

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HeLIX Exploration PLC (AIM:HEX) chairman David Minchin talked with Proactive's Stephen Gunnion about the successful completion of drilling at the Clink #1 well within the Ingomar Dome project in Montana.

Minchin noted the completion of drilling ahead of schedule and under budget, with helium shows detected across all target horizons. In an unexpected turn, up to 10.3% hydrogen was also discovered in the Cambrian strata.

He highlighted the significance of the helium shows, noting that it signals helium presence throughout their system, a crucial step before wire lining and flow testing. He cautiously mentioned the potential for a hydrogen, helium, and nitrogen system in multiple formations, which could positively impact their future operations if commercial quantities are confirmed.

Looking ahead, Minchin detailed the next steps, including the wire lining, flow testing, and the analysis of gas samples, with results expected soon. These findings will inform the company's development strategy as it progresses towards possible commercial discovery.

Visit Proactive's YouTube channel for more videos, and don't forget to give the video a like, subscribe to the channel, and enable notifications for future content.

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London's FTSE 100 eased higher ahead of a big day on the US tech front with Nvidia and CrowdStrike to report later.

London’s blue-chip index was up five points at 8,349 in early trades.

GSK was a riser as the Delaware Supreme Court said it would review a previous adverse ruling in its Zantac litigation battle. The UK pharma company noted that such interlocutory reviews are granted in ‘exceptional circumstances’.

Sports Direct owner Frasers has purchased a 14.65% strategic investment in Accent, a leading retail and distribution business in the performance and lifestyle market in Australia and New Zealand.

Prudential fell after a mixed set of interims that were affected by the economic woes in Hong Kong and China. Even so, the life insurer maintained its forecast for new business growth of 15-20% over the next three years.

Finally, the water sector has said that a proposed cap on bill hikes will create a risk of failures across the industry. An average £19 a year ceiling “would likely result in significant investability issues for the sector as a whole,” said the report from trade body WaterUK.

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Riversgold Ltd (ASX:RGL) chairman David Lenigas discusses the latest assay results from the Northern Zone Intrusive Hosted Gold Project, located 25 kilometres east-south-east of the Kalgoorlie Super Pit in Western Australia.

Lenigas expressed enthusiasm about the recent drilling results, which exceeded the company’s expectations. He highlighted the discovery of a high-grade supergene zone with grades ranging from 2 to 5 grams of gold per tonne, starting at about 30 meters in depth.

Lenigas also discussed the project's strategic location near Kalgoorlie, emphasising its excellent logistics, access to third-party processing plants, and proximity to other active operations like Black Cat Syndicate. He shared that Riversgold is planning further drilling, targeting additional JORC resources, with the goal of commencing a high-grade open pit operation.

"With the Aussie dollar gold price now at $3,700 an ounce, we’re very excited about the potential of this project," Lenigas said, reinforcing the company's positive outlook on the gold market.

Don't miss out on more updates and insights—visit Proactive’s YouTube channel for additional videos. Don't forget to like this video, subscribe to the channel, and enable notifications for future content.

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Far East Gold Ltd (ASX:FEG) CEO Shane Menere joins Proactive’s Tylah Tully to discuss a successful $4 million capital raise to advance exploration at its Trenggalek, Idenburg and Woyla gold and copper projects in Indonesia.

The capital was accumulated through a combination of an institutional placement, which raised $2.3 million, and a share purchase plan (SPP) that concluded on August 20, 2024, garnering $1.75 million. The SPP received strong shareholder support, leading to the issuance of 12,874,508 shares at $0.136 per share.

The company says the funds will be instrumental in advancing exploration across the company’s portfolio of potential tier-1 assets. The next six months will be pivotal for the company’s growth.

The new shares from the SPP are expected to be allotted on August 27, 2024, and will rank equally with existing shares. Reach Markets acted as the sole lead manager for both the SPP and the placement.

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Element 25 Ltd (ASX:E25, OTCQX:ELMTF) managing director Justin Brown joins Proactive’s Tylah Tully to discuss the completion of resource infill drilling at its 100%-owned Butcherbird Manganese Project in the Pilbara region of Western Australia.

The campaign has successfully confirmed the continuity of mineralisation, boding well for future exploration and potential resource growth.

E25 completed 216 percussion drill holes totalling 6,203 metres with 5,513 samples submitted for analysis. The results are consistent with the geological model and confirm mineralisation within existing Butcherbird resources, which are designated for the planned expansion of mining operations.

The aim of this drilling program was to gather sufficient data to support a re-evaluation of mineral resources and reserves, which will underpin the expansion of Butcherbird’s manganese concentrate production to approximately 1.1 million tonnes per annum.

The Butcherbird Project hosts a global mineral resource exceeding 260 million tonnes of manganese ore. An updated mineral resource and ore reserve estimate is expected by the end of September 2024.

Element 25 has engaged IHC Robbins to undertake the resource upgrade, which is anticipated to improve the classification of resources from inferred to measured and indicated, thereby supporting the planned production increase.

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Lumos Diagnostics Ltd (ASX:LDX, OTC:LDXHF) chief technology officer Sacha Dopheide joins Proactive’s Tylah Tully to discuss an extended agreement with Burnet Diagnostics Initiative (BDI) to further develop and manufacture a liver function test based on Alanine Transaminase (ALT) levels.

The BDI agreement includes the production of ALT lateral flow tests, customised Lumos readers and a mobile application for use in an upcoming US clinical trial. The partnership, which began with a feasibility project in July 2023, aims to address critical clinical needs through rapid point-of-care testing.

The new phase of the collaboration is set to begin in August 2024 and will focus on the production of a point-of-care ALT testing system, specifically designed to monitor liver function in high-risk patients. The ALT test is expected to provide rapid results, enabling quicker detection of acute liver toxicity, potentially caused by drug reactions. Lumos will offer development, regulatory and manufacturing services over the next 9-12 months, with projected revenues between US$700,000 and US$1 million.

If successful, Lumos may continue to support BDI in further development stages, including additional trials and regulatory submissions. The partnership underlines Lumos’ commitment to advancing point-of-care diagnostics and improving patient outcomes.

Partnerships and agreements form a large part of the company’s revenue stream helping it leverage its other client offerings.

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Bit Digital CEO Sam Tabor joined Steve Darling from Proactive to discuss the company's impressive unaudited financial results for the second quarter of 2024. Bit Digital experienced a significant revenue increase, achieving $29 million in total revenue for Q2, marking a 220% growth compared to the same period in 2023. This surge in revenue was largely attributed to the commencement of the company's high-performance computing (HPC) services business and the benefit of a higher realized bitcoin price.

In detail, the revenue from bitcoin mining amounted to $16.1 million, reflecting an 80% increase from the previous year's quarter. The HPC business, a new addition to Bit Digital's operations, contributed $12.5 million in revenue during the quarter, compared to zero in the prior year. However, the company reported earning 244.2 bitcoins in Q2 2024, a 23% decrease from the previous year. This decline was mainly due to a reduction in block rewards following the halving event in April 2024.

Tabor also revealed that Bit Digital is poised to further capitalize on its growth by signing a binding term sheet with Boosteroid, a new customer for its HPC business. Upon the finalization of a master service agreement, Boosteroid will place an initial purchase order for GPU servers with a five-year service duration. This order is expected to generate approximately $13 million in revenue for Bit Digital over the five-year term, averaging about $2.6 million per year. However, the execution of this agreement is contingent upon further due diligence, customary legal and business reviews, internal approvals, and the successful negotiation of the master service agreement.

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SolarBank Corporation CEO Richard Lu joined Steve Darling from Proactive to share news about the company's latest venture—a 6.41 MW DC ground-mount solar power project in East Bloomfield, New York. Known as the East Bloomfield project, this initiative represents a significant step forward in SolarBank's mission to expand renewable energy infrastructure in the state. The project is anticipated to qualify for incentives under the New York State Energy Research and Development Authority (NYSERDA) NY-Sun Program, which aims to make solar energy more accessible and affordable for residents.

The company has already received a Special Use Permit from the Town of East Bloomfield, marking a critical milestone in the project's development. Moving forward, SolarBank will focus on completing the permitting process and securing the necessary financing to bring the project to fruition.

Once operational, the East Bloomfield project will function as a community solar initiative. Community solar involves a collection of solar panels connected to the local electricity grid, allowing residents to benefit from clean energy without having to install panels on their own properties. As the solar panels generate electricity, the energy is fed directly into the local power grid, contributing to a more sustainable energy system.

However, the development of the East Bloomfield project is contingent on several factors, including obtaining interconnection approval, acquiring the required permits, and ensuring the continued availability of third-party financing. Additionally, the inherent risks associated with constructing a solar power project will need to be managed effectively to bring this ambitious project to completion.

With these steps underway, SolarBank Corporation is poised to make a substantial contribution to New York's clean energy goals while providing the local community with access to renewable energy through this innovative solar project.

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