🧬 Protein Restriction, Aging, and Longevity ⏳

A remarkable new study in Cell shows that moderate protein restriction—especially when started in midlife—can reprogram aging biology across 41 organs, improving metabolic and cardiovascular health. 🫀⚙️

Using deep multi-organ proteomics in mice and human plasma validation, the authors demonstrate benefits mediated through ↓ IGF-1, ↓ mTOR, ↑ AMPK, and activation of brown adipose tissue. Importantly, the data also caution that extreme protein restriction may provoke inflammation, underscoring that moderation matters. ⚠️🎯

A powerful example of how nutrition shapes the biology of aging—organ by organ, pathway by pathway.

📖 Cell (2025)

#Aging #Longevity #ProteinRestriction #MetabolicHealth #CardiovascularHealth #Proteomics #PrecisionNutrition